Acute toxicity effects of mercury and other heavy metals on HeLa cells and human lymphocytes evaluated via microcalorimetry

McGuinness, Susan M.; Roess, Deborah A.; Barisas, B. George

doi:10.1016/0040-6031(90)80567-i

Cited by 16 publications

(3 citation statements)

References 25 publications

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“…Highly soluble compounds of mercury, lead, copper, and cadmium were chosen. These studies showed a correlation between toxicity and sulfhydryl affinity, suggesting that cross-linking membrane proteins (20) is a major factor in the toxic effects of these materials. The relative affinities of the metals for sulfhydryl groups, Hg > Pb > Cu > Cd (21), are in agreement with the relative toxicity values.…”

Section: Discussionmentioning

confidence: 94%

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Acute toxicity measurements on aquatic pollutants using microcalorimetry on tissue-cultured cells

McGuinness¹,

Barisas²

1991

Environ. Sci. Technol.

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Section: Discussionmentioning

confidence: 94%

“…Toxicant concentrations equaled the published EC50 values measured by the Microtox bacterial chemiluminescence assay. These experiments were performed at 20 °C, the optimum Microtox test temperature. The rate of heat production in Microtox bacteria was approximately 0.2 pW/cell.…”

Section: Introductionmentioning

confidence: 99%

Acute toxicity measurements on aquatic pollutants using microcalorimetry on tissue-cultured cells

McGuinness¹,

Barisas²

1991

Environ. Sci. Technol.

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“…Cytological effects of inorganic, phenyl-and alkylmercuric compounds (e.g., phenylmercuric chloride, butylmercuric chloride and ethylmercuric chloride) on HeLa cell [18].…”

Section: Dmentioning

confidence: 99%

Mercury Toxicity: Ecological Features of Organic Phase of Mercury in Biota- Part I

Aljerf

AlMasri

2018

AOICS

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Mercury is extensively used in industry with top usage in electrolytic chlorine. As a result of this elemental consumption in industry, different forms of inorganic and organic mercury get into the environment in great piles every day and many of these mercurial derivatives are converted to methylmercury by microorganisms. The study is assigned to inspect the ecological features of organic mercury species in biological and marine environments. In addition, the paper takes into account the uptake and the distribution of mercury in fish to investigate the conversion and mobilization of mercury from sediment deposits into the general environment. It has been confirmed that the biological half-life of methylmercury in human is about 70 days. In methodology, molecular identification of mercury has been defined. Monomethyl mercury in sediments was analyzed by gas chromatography (GC) hyphenated with electron capture detector (ECD) and the confirmation was measured by mass spectroscopy (MS). The conversion of mercury element to its organic species has been illustrated. In soil, it was found that lower pH favors monomethyl mercury and the higher pH, dimethylmercury formation, respectively. Dimethylmercury is the biological poisoning product and methylmercury is an artifact of isolation procedure. In next paper, we will turn to study the epidemiological features of organic phase of mercury and investigate in deep the distribution, metabolism, and toxicity of mercury and methylmercury in some essential raw food materials, domestic animal feedstock, and some other biological specimens using basically simple analytical methods of chromatography as paper (PC) and thin layer (TLC).

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Kinetics of the Action of Na₂SeO₃ on Bacillus subtilis Growth as Studied by Microcalorimetry

et al. 2002

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ChinaMicrocalorimetric biorssay for acute Cellular toxicity is based on metabolic heat production from cultured cells. The bidogical respolr~e to bximb is the iahibiti~~~ Of the h a t production rate in Cells, and toxicity is expressed as the concentlation at toxicant that is 9% effective m this inhibition ( IC,). In thif paper, the effect of N%SeO, on I3adu.s subtilir growth ~invgtigatodat37'Tbymieroeaiorhnetry.'lherelatioo-N%SeO,(c) shows a logarithmic Iy)rmBI dwribution, and ship between growrh rate constants (1) and amcentration of IC,b 20.3 pg/mL. Au these t k l m o k k f k i n f o d o n is r e d l y OMained by I UI LKB 227'7-204 beat cooduction micmcslorimeter. Micmcalorhwtry is a quantitative, inexpensive, and versatile method for toxicology research.

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Acute toxicity effects of mercury and other heavy metals on HeLa cells and human lymphocytes evaluated via microcalorimetry

Cited by 16 publications

References 25 publications

Acute toxicity measurements on aquatic pollutants using microcalorimetry on tissue-cultured cells

Acute toxicity measurements on aquatic pollutants using microcalorimetry on tissue-cultured cells

Mercury Toxicity: Ecological Features of Organic Phase of Mercury in Biota- Part I

Kinetics of the Action of Na₂SeO₃ on Bacillus subtilis Growth as Studied by Microcalorimetry

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Acute toxicity effects of mercury and other heavy metals on HeLa cells and human lymphocytes evaluated via microcalorimetry

Cited by 16 publications

References 25 publications

Acute toxicity measurements on aquatic pollutants using microcalorimetry on tissue-cultured cells

Acute toxicity measurements on aquatic pollutants using microcalorimetry on tissue-cultured cells

Mercury Toxicity: Ecological Features of Organic Phase of Mercury in Biota- Part I

Kinetics of the Action of Na2SeO3 on Bacillus subtilis Growth as Studied by Microcalorimetry

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Kinetics of the Action of Na₂SeO₃ on Bacillus subtilis Growth as Studied by Microcalorimetry