Acute Toxicity in High-Risk Prostate Cancer Patients Treated With Androgen Suppression and Hypofractionated Intensity-Modulated Radiotherapy

Acute Toxicity of Hypofractionated Intensity-Modulated Radiotherapy for Prostate Cancer

“…That change is demonstrated in the current study, with its safe reduction in ptv68 margins (compared with 33 , who reported accuracy of 1-mm margin expansion for static targets and 1.5-mm margin expansion for moving targets (long-term outcome results are pending). Unlike our previous study 10 , which demonstrated a correlation between V 60 rectum and rectal acute toxicity, the present study did not find statistical correlations of acute gu and gi toxicity with dosimetric and volumetric parameters of rt (p = 0.085).…”

“…The study stems from a previous investigation of a hfrt regimen using 68 Gy in 25 fractions 10 . The present trial used further dose escalation to 75 Gy in 25 fractions to the boost volume, dose escalation to 50 Gy in 25 fractions to the plns, and smaller planning target volume (ptv) margins.…”

“…Since the early 2000s, to further improve local disease control in prostate cancer, multiple studies [6][7][8][9][10] have explored the feasibility and efficacy of hfrt based on the concept that prostate cancer cells have a low α:aab ratio (0.8-1.5). A low ratio theoretically demonstrates a therapeutic gain with the use of hfrt 5 .…”

Comparison of dosimetric parameters and acute toxicity after whole-pelvicvsprostate-only volumetric-modulated arc therapy with daily image guidance for prostate cancer

“…The pre-sacral lymph nodes were not irradiated in many WP IMRT series in the context of conventionally fractionated 8,10,30,32 and hypofractionated 33,34 RT. Similar to other institutions, 10,34 the reason for the nodal CTV definition used at our institution is that inclusion of the presacral nodes could potentially increase the volume of the rectum, bladder and bowel bag irradiated at the low-to medium-dose levels, which could further impact GI and GU toxicities.…”

Reducing radiation-associated toxicity using online image guidance (IGRT) in prostate cancer patients undergoing dose-escalated radiation therapy

“…3,9,19,25,26 These data are limited in terms of the quantifiable benefits of IGRT due to differences in the number of patients, the protocols and the dose constraints. Contradictory to our results, the incidence of grade 2 GI effects was 30%, compared to 35% in the non-IGRT group, in the study by Gill et al 9 after delivering a total dose of 78 Gy.…”