Acute Toxicity of Aqueous and Ethanol Extracts of Dialium Guineense Stem Bark

Abu, O.D.; Onoagbe, I. O.

doi:10.46344/jbino.2021.v10i02.02

Cited by 9 publications

(10 citation statements)

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“…On the other hand, the levels of NO and MDA elevated by STZ were markedly reduced after treatment with MEDG. These results are in agreement with reports of previous studies [25][26][27][28][29][30][31].…”

Section: Discussionsupporting

confidence: 94%

Renal Oxidative Status in Diabetic Wistar Rats Administered Methanol Fraction of Ethanol Extract of Dialium guineense Stem Bark

Abu

2023

MCCRJ

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Survey has shown that the number of persons with diabetes mellitus (DM) would increase in the coming decade. Diabetes mellitus is primarily defined by the level of hyperglycemia which causes nephropathy. The present study investigated renal oxidative status of diabetic rats administered methanol fraction of ethanol extract of Dialium Guineense (MEDG) stem bark. Male Wistar rats (n = 25, mean weight = 215 ± 15 g) were randomly assigned to five groups (5 rats per group): normal control, diabetic control, metformin, and 200 mg/kg body weight (bwt) and 300 mg/kg bwt extract groups. Diabetes mellitus was induced via intraperitoneal injection of streptozotocin (STZ, 50 mg/kg bwt). The diabetic rats were then treated for 21 days with metformin (50 mg/kg bwt) or the extract at doses of 200 and 300 mg/kg bwt, respectively. The results showed that the activities of catalase, superoxide dismutase (SOD), glutathione peroxidase (GPX), and Glutathione Reductase (GR) as well as levels of reduced glutathione (GSH) and % GSH were significantly lower in diabetic control group than in the normal control group, but they were increased by MEDG treatment (p < 0.05). On the other hand, the levels of nitric oxide (NO) and malondialdehyde (MDA) elevated by STZ were markedly reduced after treatment with MEDG (p < 0.05). It can be concluded that MEDG stem bark possesses an ameliorative potential against STZ-induced oxidative stress in rats.

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Section: Discussionsupporting

confidence: 94%

Renal Oxidative Status in Diabetic Wistar Rats Administered Methanol Fraction of Ethanol Extract of Dialium guineense Stem Bark

Abu

2023

MCCRJ

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“…Their use in disease management is as old as man. Medicinal plants serve as cheap alternative to orthodox medicine since they are readily available [38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54].…”

Section: Discussionmentioning

confidence: 99%

Cardiac Oxidative Status in Diabetic Wistar Rats Exposed To Ethanol Extract of Cucumis Sativus Fruit

OD,

2023

J Diagn Case Rep

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The present study investigated cardiac oxidative status in diabetic Wistar rats exposed to ethanol extract of Cucumis sativus fruit. Male Wistar albino rats (n = 25, mean weight = 215 ± 15 g) were randomly assigned to five groups of 5 rats each: normal control, diabetic control, metformin, extract (200 mg/kg body weight, bwt) and extract (300 mg/kg bwt) groups. Diabetes mellitus was induced in the rats via intraperitoneal injection of 50 mg/kg bwt STZ. The diabetic rats were treated for 21 days with either metformin (50 mg/kg bwt) or the extract. Activities of antioxidant enzymes such as catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) as well as molecules like reduced glutathione (GSH), total protein (TP), malondialdehyde (MDA) and nitric oxide (NO) were measured in heart homogenate. The results showed that induction of diabetes mellitus with STZ significantly increased the fasting blood glucose (FBG) concentrations of the rats, while decreasing the activity/concentration of antioxidant enzymes/ molecules (p < 0.05). However, treatment of the diabetic Wistar rats with the extract markedly reduced the FBG concentration and body weights of rats, but enhanced the activity/concentration of antioxidant enzymes/molecules in cardiac tissue (p < 0.05). These results indicate that ethanol extract of the medicinal plant fruit has the potential to promote antioxidant defense in the heart of STZ-induced diabetic rats.

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“…A major setback limiting the use of plant extracts in modern medicine is the inability to ascertain safe dose. Many medicinal plants known to be effective against a number of diseases have also been shown to be toxic at certain doses and prolonged exposure [18] . Drugs continue to be taken off the market due to possible hepatorenal toxicity.…”

Section: Discussionmentioning

confidence: 99%

“…Dialium guineense is a medicinal plant used in Traditional Medicine for the treatment of different disease conditions, such as diarrhea, severe cough, bronchitis, wound, stomachaches, malaria, jaundice, ulcer and hemorrhoids [15][16][17] . Although the acute toxicity of its extracts have been reported, not much is known about the subchronic toxicity of the plant [18] . The aim of this study was to investigate the effect of extracts of D. guineense stem bark on lipid peroxidation index and histological changes in kidneys of normal rats.…”

Section: Introductionmentioning

confidence: 99%

Effect of extracts of dialium guineense stem bark on lipid peroxidation index and histological changes in kidneys of normal rats

OD¹,

OS²,

EG³

2022

Int. J. Forensic Med.

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To investigate the effect of extracts of Dialium guineense stem bark on lipid peroxidation index and histological changes in kidneys of normal rats. Materials and Methods: Adult male Wistar rats (n = 70; 35 rats per extract) weighing 160 to 180 g were divided into seven (7) groups of five (5) rats each. Group I served as control, while rats in the other groups were administered varied doses of extract (200 -5000 mg/kg body weight, bwt) orally for a duration of 28 days. Tissue malondialdehyde (MDA) level was measured as well as histopathological assessment.Results: Percentage increases in body weights of rats treated with aqueous or ethanol extract of D. guineense stem bark were significantly reduced, when compared with control group (p< 0.05), but there were no significant differences in the corresponding relative organ weights and tissue MDA level among the groups (p> 0.05). Similarly, the extracts did not significantly alter the normal architecture of the kidney. Conclusion:The aqueous and ethanol extracts of the medicinal plant did not elicit any deleterious effects on rat kidney.

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Acute Toxicity of Aqueous and Ethanol Extracts of Dialium Guineense Stem Bark

Cited by 9 publications

References 0 publications

Renal Oxidative Status in Diabetic Wistar Rats Administered Methanol Fraction of Ethanol Extract of Dialium guineense Stem Bark

Renal Oxidative Status in Diabetic Wistar Rats Administered Methanol Fraction of Ethanol Extract of Dialium guineense Stem Bark

Cardiac Oxidative Status in Diabetic Wistar Rats Exposed To Ethanol Extract of Cucumis Sativus Fruit

Effect of extracts of dialium guineense stem bark on lipid peroxidation index and histological changes in kidneys of normal rats

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