Acute toxicity of C60–Cis-Pt nanocomplex in vivo

Lynchak, Oksana; Byelinska, І.V.; Dziubenko, Natalia; Kuznietsova, Halyna; Абрамчук, Ольга Миколаївна; Prylutska, Svitlana

doi:10.1007/s13204-021-01680-3

Cited by 1 publication

(1 citation statement)

References 42 publications

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“…Other types of CNMs, such as fullerenes, NDs, CNOs, HMCS, and CNHs, may not be as popular, but they show potential as nanocarriers due to their unique properties. For example, NDs offer improved biocompatibility over other CNMs [114,166], whilst fullerenes and CNOs display ease of functionalisation, narrow PDI, and ease of production [23,59]. In terms of drug moieties, antimicrotubule agents were the most popular payloads for these nanocarriers (Figure 2).…”

Section: Discussionmentioning

confidence: 99%

Carbon Nanomaterials (CNMs) in Cancer Therapy: A Database of CNM-Based Nanocarrier Systems

2023

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Carbon nanomaterials (CNMs) are an incredibly versatile class of materials that can be used as scaffolds to construct anticancer nanocarrier systems. The ease of chemical functionalisation, biocompatibility, and intrinsic therapeutic capabilities of many of these nanoparticles can be leveraged to design effective anticancer systems. This article is the first comprehensive review of CNM-based nanocarrier systems that incorporate approved chemotherapy drugs, and many different types of CNMs and chemotherapy agents are discussed. Almost 200 examples of these nanocarrier systems have been analysed and compiled into a database. The entries are organised by anticancer drug type, and the composition, drug loading/release metrics, and experimental results from these systems have been compiled. Our analysis reveals graphene, and particularly graphene oxide (GO), as the most frequently employed CNM, with carbon nanotubes and carbon dots following in popularity. Moreover, the database encompasses various chemotherapeutic agents, with antimicrotubule agents being the most common payload due to their compatibility with CNM surfaces. The benefits of the identified systems are discussed, and the factors affecting their efficacy are detailed.

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