Acute toxicity of fenthion to freshwater lamellibranch mollusc,Indonaia caeruleus (Prashad 1918), from Godavari river at Paithan—A biochemical approach

Mane, U. H.; Akarte, S. R.; Kulkarni, Devdutt

doi:10.1007/bf01607813

Cited by 17 publications

(5 citation statements)

References 9 publications

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“…Any interference with either enzyme can lead to impairment of cellular functions at biochemical level. Similar observations have been made by many workers (Jagtap et al., 2011; Mane et al., 1986; Mule & Lomte, 1995; Muley & Mane, 1989; Mane and Kulkarni , 1999) in molluscs. In our study, ALT decreased in experimental animals treated with spirulina and TBTCl compared to the experimental group treated with TBTCl where ALT increased.…”

Section: Discussionsupporting

confidence: 88%

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Effect of anti‐fouling organotin compound (TBTCl) and the ameliorative role of spirulina on Lamellidens marginalis

Sharma

Nayak

Pradhan

et al. 2023

Environmental Quality Mgmt

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Organotin compounds (OTs) belong to persistent organic pollutants (POPs) group and are capable of persisting up to 40 years due to their chemical nature. Tributyltin (TBT) is an anti‐fouling agent and can easily leach out into water threatening the aquatic life. Molluscs are sensitive towards the presence of toxins in their surrounding environment and respond accordingly to overcome stress conditions. Lamellidens marginalis, a freshwater bivalve is popular for its food value and pink pearls. The present study focuses on the effect of Tributyltin chloride (TBTCl), a form of TBT, on Lamellidens marginalis under laboratory conditions. The 96 h median lethal concentration (LC50) was calculated to be 1 mg L−1. Bivalves were segregated into three sub‐groups that is, group I; control, group II; experimental (treated with 0.2 mg L−1 TBTCl that is, 1/5th of LC50 value), group III; experimental (treated with 0.2 mg L−1 TBTCl + 0.003% w/v spirulina). A static non‐renewal toxicity assay was performed for 96 h. Estimation of total protein, acid phosphatase (ACP), alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and glycogen was carried out. An overall decrease in the total protein, ACP, ALP, glycogen, and ALT was observed in both the experimental groups (Groups II and III) in comparison to the control group whereas, the concentration of AST was found to increase in hepatopancreas. Integrated biomarker response index (IBR) value was calculated to be 12.60 for control and 10.56 and 11.29 for groups II and III, respectively in hepatopancreas. Similarly, in gill tissue the values were 3.69, 1.37, and 3.43, respectively. After treatment with nutritional supplement spirulina, a higher BRI (biomarker response index) value of 3.3 for group III was observed, suggesting the therapeutic role of spirulina in test organisms. BRI value derived for group II was 2.7 indicating more severity of TBTCl compared to group III in the absence of spirulina.

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Section: Discussionsupporting

confidence: 88%

“…with either enzyme can lead to impairment of cellular functions at biochemical level. Similar observations have been made by many workers (Jagtap et al, 2011;Mane et al, 1986;Mule & Lomte, 1995;Muley & Mane, 1989;Mane and Kulkarni , 1999)…”

Section: E X H I B I Tsupporting

confidence: 89%

Effect of anti‐fouling organotin compound (TBTCl) and the ameliorative role of spirulina on Lamellidens marginalis

Sharma

Nayak

Pradhan

et al. 2023

Environmental Quality Mgmt

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“…In the case of PhACs, similar concentrations of acetaminophen, caffeine, carbamazepine, and fluoxetine have been previously reported in P. clarkii and clams Ruditapes decussatus caught in their habitat [ 17 , 47 ]. PhACs such as acetaminophen (widely used over-the-counter analgesic); hydrochlorothiazide (used for the hypertension treatment); and tramadol (opioid painkiller) were the compounds with the highest detection frequency, detected in 100% of the samples analyzed.…”

Section: Resultssupporting

confidence: 67%

“…The U.S. Environmental Protection Agency (EPA) has classified it as a restricted-use pesticide due to its toxic effects on birds, reptiles, and fish [ 46 ]. A significant decrease in protein was demonstrated in the middle mantle of Lamellidens corrianus when exposed to nominal (7 ng g −1 ) and lethal (14 ng g −1 ) concentrations of fenthion [ 47 ]. This compound was detected in 100% of the L. gibbosus and C. fluminea samples at concentrations above lethal concentrations.…”

Section: Resultsmentioning

confidence: 99%

An effective method for the simultaneous extraction of 173 contaminants of emerging concern in freshwater invasive species and its application

Manjarrés-López,

Vitale,

Callejas-Martos

et al. 2023

Anal Bioanal Chem

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A robust and efficient extraction method was developed to detect a broad range of pollutants of emerging interest in three freshwater invasive species: American red crab (Prokambarus clarkii), Asian clam (Corbicula fluminea), and pumpkinseed fish (Lepomis gibbosus). One native species, “petxinot” clam (Anodonta cygnea), was also evaluated. Invasive species are often more resistant to contamination and could be used in biomonitoring studies to assess the effect of contaminants of emerging concern on aquatic ecosystems while preserving potentially threatened native species. So far, most extraction methods developed for this purpose have focused on analyzing fish and generally focus on a limited number of compounds, especially analyzing compounds from the same family. In this sense, we set out to optimize a method that would allow the simultaneous extraction of 87 PhACs, 11 flame retardants, 21 per- and poly-fluoroalkyl substances, and 54 pesticides. The optimized method is based on ultrasound-assisted solvent extraction. Two tests were performed during method development, one to choose the extraction solvent with the best recovery efficiencies and one to select the best clean-up. The analysis was performed by high-performance liquid chromatography coupled to high-resolution mass spectrometry. The method obtained recoveries between 40 and 120% and relative standard deviations of less than 25% for 85% of the analytes in the four validated matrices. Limits of quantification between 0.01 ng g−1 and 22 ng g−1 were obtained. Application of the method on real samples from the Albufera Natural Park of Valencia (Spain) confirmed the presence of contaminants of emerging concern in all samples, such as acetaminophen, hydrochlorothiazide, tramadol, PFOS, carbendazim, and fenthion. PFAS were the group of compounds with the highest mean concentrations. C. fluminea was the species with the highest detection frequency, and P. clarkii had the highest average concentrations, so its use is prioritized for biomonitoring studies. Graphical abstract

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“…The increased gametogenesis observed in pesticide-exposed clams may be directly related with the enhanced metabolic rate suggested by the higher CCO activity. Energy costs induced by contaminant exposure are well documented for mollusks, and disturbances in energy reserves in certain tissues occur because of a dysfunction of physiological processes controlling the numerous pathways of catabolism, metabolism, and the liberation of glycogen or lipids [27]. The precise mechanisms of toxicity of chlorophenoxy herbicides have not been fully elucidated.…”

Section: Pesticide Effects In Specimens Kept At 78cmentioning

confidence: 99%

Physiological effects of temperature and a herbicide mixture on the soft‐shell clam Mya arenaria (Mollusca, Bivalvia)

Greco

Pellerin

Capri

et al. 2010

Enviro Toxic and Chemistry

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Abstract-The aim of the current study was to investigate effects of temperature and a mixture of herbicides on the physiological status of the bivalve Mya arenaria. Bivalves acclimated to two temperatures (7 and 188C) were exposed for 28 d to 0.01 mg/L of a pesticide formulation containing dichlorophenoxyacetic acid (2,4-D), 2-(2-methyl-4-chlorophenoxy) propionic acid (mecoprop), and 3,6-dichloro-2-methoxybenzoic acid (dicamba). At days 7, 14, and 28, mortality, immune parameters (hemocyte number, phagocytic activity, and efficiency), biomarkers of oxidative stress (catalase [CAT] and superoxide dismutase [SOD] activities and malondialdehyde [MDA] content), the metabolic enzyme cytochrome C oxidase (CCO), a biomarker of pesticide exposure (acetylcholinesterase [AChE]), and the activity of an enzyme related to gametogenesis (aspartate transcarbamylase [ATCase]) were monitored in clam tissues. Gonadosomatic index (GSI), condition factor (CF), and sex were also assessed. In clams acclimated to 78C, exposure to pesticide enhanced CCO activity and CF and decreased MDA content, hemocyte number, CAT, and SOD activities. In clams kept at 188C, pesticide effects appeared minor compared with samples kept at 78C. In bivalves acclimated to 188C, CCO, SOD, and ATCase activity and MDA content were enhanced, and hemocyte number, CAT, and AchE activities and phagocytosis were suppressed. In samples exposed to pesticides, increased temperature enhanced MDA content and CCO and SOD activity and suppressed hemocyte number and CAT and AchE activity. A gradual sexual maturation was observed in both sexes through experimental time, but females had a higher sensitivity to temperature and pesticides compared to males. Increased temperature altered the ability of the sentinel species Mya arenaria to respond to pesticide exposures. Further work is needed to understand the impacts of increasing temperature on the whole St. Lawrence estuary ecosystem. Environ. Toxicol. Chem. 2011;30:132-141. # 2010 SETAC

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Acute toxicity of fenthion to freshwater lamellibranch mollusc,Indonaia caeruleus (Prashad 1918), from Godavari river at Paithan—A biochemical approach

Cited by 17 publications

References 9 publications

Effect of anti‐fouling organotin compound (TBTCl) and the ameliorative role of spirulina on Lamellidens marginalis

Effect of anti‐fouling organotin compound (TBTCl) and the ameliorative role of spirulina on Lamellidens marginalis

An effective method for the simultaneous extraction of 173 contaminants of emerging concern in freshwater invasive species and its application

Physiological effects of temperature and a herbicide mixture on the soft‐shell clam Mya arenaria (Mollusca, Bivalvia)

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