Acute Toxicity of Insecticide Thiamethoxam to Crayfish (Astacus leptodactylus): Alterations in Oxidative Stress Markers, ATPases and Cholinesterase

Uçkun, Miraç; Yoloğlu, Ertan; Uçkun, Aysel Alkan; Öz, Özden Barım

doi:10.17344/acsi.2021.6823

Cited by 15 publications

(6 citation statements)

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“…In addition to maintaining ionic regulation, they also provide the energy required for the transport of metabolites (Oluah et al, 2020;Temiz et al, 2018). In cray sh (Astacus leptodactylus) tissues, sublethal doses of TMX were reported to inhibit enzyme activities responsible for ion regulation (Na + /K + -ATPase, Ca 2+ ATPase) in a dose-dependent manner at 96 hours of exposure (Uçkun et al, 2021).In present study, Na + /K + -ATPase and Ca 2+ ATPase enzymes, which are renal ionoregulation enzyme parameters, showed a signi cant dose-dependent decrease in TMX exposure for 7 days (Fig. 5.).…”

Section: Discussionmentioning

confidence: 99%

“…al., 2018; Sera ni et al, 2019; Tian et al, 2018;Uçkun et al, 2021). According to recent studies, pesticides cause reversible or irreversible inactivation of AChE enzyme activity depending on the toxic effect of the compounds and as a result, cholinergic intoxication has been determined toxic effect of the compounds and as a result, cholinergic intoxication has been determined(Biancardi et al, 2022;Moss, 2020;Umar & Aisami, 2020) …”

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confidence: 99%

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Physiological responses of oxidative damage, genotoxicity and hematological parameters of the toxic effect of neonicotinoid-thiamethoxam in Oreochromis niloticus

Temiz,

Kargın

2024

Environmental Toxicology and Pharmacology

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Physiological responses of oxidative damage, genotoxicity and hematological parameters of the toxic effect of neonicotinoid-thiamethoxam in Oreochromis niloticus

Temiz,

Kargın

2024

Environmental Toxicology and Pharmacology

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“…Acute toxic effects occur within a few minutes to several hours after poisoning by pesticides [77,[96][97][98]. Poisoning impacts peripheral muscarinic and nicotinic receptors, as well as the central nervous system [99][100][101][102][103]. Some manifestations of a cholinergic crisis include nausea, vomiting, diarrhea, abdominal cramp, urinary incontinence, miosis, salivation, lacrimation, bronchorrhea, bradycardia, hypotension, fasciculation, muscle paralysis, dizziness, confusion, seizures, coma, and respiratory failure [8,100,102,[104][105][106].…”

Section: Acute Toxic Effectsmentioning

confidence: 99%

“…The results of the study indicated that acute exposure to CPF for a short duration may induce dysregulation of the neurosecretory activity of PNSCs, altered biochemical activity of brain, and reduced locomotory/swimming performance in fishes. Uçkun et al [100] investigated the acute toxic effects of Thmx on A. leptodactylus using various biomarkers (acetylcholinesterase, carboxylesterase, glutathione S-transferase, glutathione, superoxide dismutase, glutathione peroxidase, glutathione reductase, and adenosinetriphosphatases). The 96 h LC 50 value of Thmx was 8.95 mg/L as active ingredient.…”

Section: Acute Toxic Effectsmentioning

confidence: 99%

Exposure Routes and Health Risks Associated with Pesticide Application

Tudi

et al. 2022

Toxics

138

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Pesticides play an important role in agricultural development. However, pesticide application can result in both acute and chronic human toxicities, and the adverse effects of pesticides on the environment and human health remain a serious problem. There is therefore a need to discuss the application methods for pesticides, the routes of pesticide exposure, and the health risks posed by pesticide application. The health problems related to pesticide application and exposure in developing countries are of particular concern. The purpose of this paper is to provide scientific information for policymakers in order to allow the development of proper pesticide application technics and methods to minimize pesticide exposure and the adverse health effects on both applicators and communities. Studies indicate that there are four main pesticide application methods, including hydraulic spraying, backpack spraying, basal trunk spraying, and aerial spraying. Pesticide application methods are mainly selected by considering the habits of target pests, the characteristics of target sites, and the properties of pesticides. Humans are directly exposed to pesticides in occupational, agricultural, and household activities and are indirectly exposed to pesticides via environmental media, including air, water, soil, and food. Human exposure to pesticides occurs mainly through dermal, oral, and respiratory routes. People who are directly and/or indirectly exposed to pesticides may contract acute toxicity effects and chronic diseases. Although no segment of the general population is completely protected against exposure to pesticides and their potentially serious health effects, a disproportionate burden is shouldered by people in developing countries. Both deterministic and probabilistic human health risk assessments have their advantages and disadvantages and both types of methods should be comprehensively implemented in research on exposure and human health risk assessment. Equipment for appropriate pesticide application is important for application efficiency to minimize the loss of spray solution as well as reduce pesticide residuals in the environment and adverse human health effects due to over-spraying and residues. Policymakers should implement various useful measures, such as integrated pest management (IPM) laws that prohibit the use of pesticides with high risks and the development of a national implementation plan (NIP) to reduce the adverse effects of pesticides on the environment and on human health.

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“…With the development of IRCFS, there has been an increasing focus on studies about the acute toxicities of insecticides to non-target crayfish ( Biever et al., 2003 ; Barbee and Stout, 2009 ; Mamun et al., 2009 ; Barbee et al., 2010 ; Yu et al., 2017 ; Zhu et al., 2022 ; Liao et al, 2023 ; Uçkun et al., 2021 ; Huang et al., 2022 ; Sun et al., 2022 ). Thiamethoxam (THI) and chlorantraniliprole (CHI) are two common insecticides that are used in paddy fields and have been widely registered as single-agent products ( Mason et al., 2000 ; Hilton et al., 2016 ; Wei et al., 2019 ; Uçkun et al., 2021 ). In recent years, the blends of THI and CHI have become popular in IRCFS.…”

Section: Introductionmentioning

confidence: 99%

Spray losses study of two pesticides by UASS in integrated rice–crayfish farming system and acute toxicity evaluation on Procambarus clarkii

Liu,

Wang,

et al. 2023

Front. Plant Sci.

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IntroductionWhile the integrated rice-crayfish (Procambarus clarkii) farming system (IRCFS) is widely developing in China, the widespread use of Unmanned Aerial Spraying Systems (UASS) to protect rice from pests has led to potential pesticide risk for the crayfish in IRCFS. Therefore, it is crucial to examine UASS’s spray deposition and drift in IRCFS.MethodIn this study, we used the oligonucleotide sequence-tracking / dot-blotting (OSTDB) method to trace pesticide spraying. We collected detailed data not only on spray loss in the paddy fields, but also on spray drift in the breeding ditches caused by upwind and downwind spray areas. Additionally, pesticide residues in the breeding ditches were measured using LC-MS/MS by collecting water samples after pesticide application.ResultsThe data analysis indicated that the spray loss in the paddy field was significantly greater than that in the breeding ditches. The spray drift in the breeding ditches, caused by the upwind spray area, was seven times higher than that originating from the downwind spray area. Furthermore, the results also revealed that the bulk flow between the paddy fields and the breeding ditches contributed a substantial amount of pesticide residue to the water body in the breeding ditches. In addition, we investigated the acute toxicities of common insecticides using in paddy fields, including thiamethoxam (THI), chlorantraniliprole (CHI), THI·CHI-Mix and THI·CHI-WG.DiscussionThe results demonstrated that the spray losses and spray drift from UASS spray applications of these pesticides in IRCFS would not cause acute toxicity or death in crayfish. These findings provide important materials for establishing pesticide application standards and guiding the field testing of droplet deposition and drift in IRCFS.

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Acute Toxicity of Insecticide Thiamethoxam to Crayfish (Astacus leptodactylus): Alterations in Oxidative Stress Markers, ATPases and Cholinesterase

Cited by 15 publications

References 93 publications

Physiological responses of oxidative damage, genotoxicity and hematological parameters of the toxic effect of neonicotinoid-thiamethoxam in Oreochromis niloticus

Physiological responses of oxidative damage, genotoxicity and hematological parameters of the toxic effect of neonicotinoid-thiamethoxam in Oreochromis niloticus

Exposure Routes and Health Risks Associated with Pesticide Application

Spray losses study of two pesticides by UASS in integrated rice–crayfish farming system and acute toxicity evaluation on Procambarus clarkii

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