Acute toxicity of latex microspheres

Yokel, Robert A.; Sabo, John P.; Simmons, Guy; DeLuca, Patrick P.

doi:10.1016/0378-4274(81)90035-7

Cited by 7 publications

(3 citation statements)

References 2 publications

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“…The current results are consistent with a series of studies reported in rats and dogs by DeLuca and colleagues. They examined the biodistribution of 141 Ce-labeled polystyrene MPs of various sizes (3, 5, 7 and 12 μm and 3, 8, 15 and 25 μm) in dogs [25, 26] and 3 μm in rats [39]. In dogs, MPs <7 μm were transiently retained in the lung eventually passing into the liver while MPs >8 μm became entrapped in the lung.…”

Section: Discussionmentioning

confidence: 99%

Threshold size for optimal passive pulmonary targeting and retention of rigid microparticles in rats

Kutscher

Chao

Deshmukh

et al. 2010

Journal of Controlled Release

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The relationship between microparticle (MP) size and lung targeting efficiency, intra-lung distribution and retention time was systematically studied after intravenous administration of rigid fluorescent polystyrene MPs of various sizes (2, 3, 6 and 10μm) to Sprague-Dawley rats. Total fluorescence was assessed and it was found that 2μm and 3μm MPs readily passed through the lung to the liver and spleen while 10μm MPs were completely entrapped in the lung for the one-week duration of the study. Approximately 84% of 6μm MPs that were initially entrapped in the lung were cleared over the next 2 days and 15% were cleared over the remaining 5 days. A Caliper IVIS® 100 small animal imaging system confirmed that 3μm MPs were not retained in the lung but that 6μm and 10μm MPs were widely distributed throughout the lung. Moreover, histologic examination showed MP entrapment in capillaries but not arterioles. These studies suggest that for rigid MPs the optimal size range required to achieve transient but highly efficiently targeting to pulmonary capillaries after IV injection is >6μm but <10μm in rats and that systemic administration of optimally sized MPs may be an efficient alternative to currently used inhalation-based delivery to the lung. KeywordsPassive pulmonary targeting; Rigid non-biodegradable microparticle; In vivo imaging

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Section: Discussionmentioning

confidence: 99%

Threshold size for optimal passive pulmonary targeting and retention of rigid microparticles in rats

Kutscher

Chao

Deshmukh

et al. 2010

Journal of Controlled Release

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“…The acute toxicity [Yokel et al, 1981], tissue interaction [Willmott and Cummings, 1987;Visseher et al, 1986;Schoen et al, 1986], and cell interaction [Kanke et al, 1986;Simon and Schmid-Schonbein, 1988;Rolland, 1989] of various MS have been investigated. The conclusions of these studies were that the toxicity of MS is consistent with observations that phagocytosis by neutrophils and macrophages may occur.…”

Section: Biological Disposition Of Microspheresmentioning

confidence: 99%

Biopolymer albumin for diagnosis and in drug delivery

Patil¹

2003

Drug Development Research

156

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This article reviews the developmental stages and strategies used to assess the biomedical utility of biopolymer albumin from the 1970s to early 2002. The basic method and mechanism(s) of preparation of albumin microspheres and subsequent modifications made to overcome the drawbacks of earlier approaches and the need for further developments are discussed, as are the processing parameters and the level of various ingredients affecting the physicochemical properties of the albumin microspheres. Different equations proposed by various investigators to modulate in vitro release kinetics are reviewed. The microscopic structural and surface properties, the chemical modification of the biopolymer (e.g., cationization, tagging with amino acids and sugar moieties) for tissue specificity or to influence the release profile and biodegradation are discussed. An array of potential diagnostic applications and the use of albumin microspheres as a drug delivery system are reviewed. Drug Dev.

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“…Sinko et al revealed that PS-3 were quickly entrapped in the rats of liver and spleen [2]. Schroeder et al reported that the PS-10 can achieve lungtargeting in rats or dogs [27,28,29]. However, it has reported that 3 mm silica microspheres were distributed in the lung, due to its adhesion and aggregation in the lung capillaries [13].…”

Section: Effect Of Microspheres Sizes On the Lung-targetingmentioning

confidence: 99%

Effect of Sizes on the Lung-Targeting and Biocompatibility of Intravenously Administered Biodegradable PLGA Microspheres

Lang

Kang

et al. 2021

Preprint

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Background: In the treatment of lung diseases, drug showed low bioavailability and efficacy by conventional administration methods. Passive lung-targeting microspheres provide a method to deliver drugs from the vascular side, there is still a paucity of systematic studies on the biocompatibility of biodegradable-polymer microspheres. Results: We used poly (lactic acid-glycolic acid) (PLGA) microspheres with different particle sizes (3, 10, 25, and 40 mm) as a model. The optimal lung-targeting particle size of the PLGA microspheres is 10 mm and the corresponding range of maximum tolerated dose is 125-150 mg/kg. We hypothesized that the decrease of blood oxygen saturation under treatment of microspheres was caused by pulmonary embolism. We found varying degrees of blood circulation loss of lungs by micro computed tomography test, which indicated severe pulmonary embolism subsequent to intravenous injection of microspheres with a particle size >25 mm. Furthermore, we found lung injury and microspheres leaked from the blood vessels into the alveoli by H&E staining. This process was likely induced by increased secretion of matrix metalloproteinases (MMPs), which destroyed the alveolar-capillary barrier and trigger an inflammatory cascade. Finally, we found that optimal particle size and dose conditions did not affect normal physiological activities after the microspheres degraded. The upregulation of vascular endothelial growth factor (VEGF) and platelet endothelial cell adhesion molecule-1 (PECAM-1 or CD31) induced vessel recanalization and reestablishment, which promoted the progress of lung repair. Conclusions: Collectively, our results highlight the importance of accurately designing the optimal size and dose of microspheres for passive lung-targeting delivery.

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Acute toxicity of latex microspheres

Cited by 7 publications

References 2 publications

Threshold size for optimal passive pulmonary targeting and retention of rigid microparticles in rats

Threshold size for optimal passive pulmonary targeting and retention of rigid microparticles in rats

Biopolymer albumin for diagnosis and in drug delivery

Effect of Sizes on the Lung-Targeting and Biocompatibility of Intravenously Administered Biodegradable PLGA Microspheres

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