Acute toxicity of nanoscale zeolitic imidazolate framework 8 (ZIF-8) to saltwater planktonic species Artemia salina and Nannochloropsis oculata

Johari, Seyed Ali; Tayemeh, Mohammad Behzadi; Veisi, Shakila; Sarkheil, Mehrdad

doi:10.1007/s11356-023-31436-1

Environ Sci Pollut Res

2023

DOI: 10.1007/s11356-023-31436-1

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Acute toxicity of nanoscale zeolitic imidazolate framework 8 (ZIF-8) to saltwater planktonic species Artemia salina and Nannochloropsis oculata

Seyed Ali Johari,

Mohammad Behzadi Tayemeh,

Shakila Veisi

et al.

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2024

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Cited by 2 publications

References 66 publications

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Carboplatin‐loaded zeolitic imidazolate framework‐8: Induction of antiproliferative activity and apoptosis in breast cancer cell

Ganapathy,

Bharathi,

Hirad

et al. 2024

Biotech and App Biochem

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The challenge with breast cancer is its ongoing high prevalence and difficulties in early detection and access to effective care. A solution lies in creating tailored metal–organic frameworks to encapsulate anticancer drugs, enabling precise and targeted treatment with less adverse effects and improved effectiveness. Zeolitic imidazolate framework‐8 (ZIF‐8) and carboplatin (CP)‐loaded ZIF‐8 were synthesized and characterized using various analytical techniques. High Resolution‐transmission electron microscopy of ZIF‐8 and CP@ZIF‐8 indicates that the particles had a spherical shape and were nanosized. The drug release rate of CP is 98% under an acidic medium (pH 5.5) because of the dissolution of ZIF‐8 into its coordinating ions, whereas 35% in a physiological medium (pH 7.4) with the addition of CP, the high porosity, and pore diameter of ZIF‐8 decrease from 1243 to 1041 m2/g. Breast cancer MCF‐7 cells were shown greater IC50 in CP@ZIF‐8 (15.01 ± 3.03 µg/mL) than free CP (34.98 ± 4.25 µg/mL) in an in vitro cytotoxicity assessment. The cytotoxicity of the CP@ZIF‐8 against MCF‐7 cells was studied using the methylthiazolyldiphenyl‐tetrazolium bromide method. The morphological changes were examined using fluorescent staining (acridine orange–ethidium bromide and Hoechst 33258) methods. The comet assay assessed the DNA fragmentation (single‐cell gel electrophoresis). The results from the study revealed that CP@ZIF‐8 can be used in the treatment of breast cancer.

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Carboplatin‐loaded zeolitic imidazolate framework‐8: Induction of antiproliferative activity and apoptosis in breast cancer cell

Ganapathy,

Bharathi,

Hirad

et al. 2024

Biotech and App Biochem

View full text Add to dashboard Cite

show abstract

Perspectives on nanomaterial-empowered bioremediation of heavy metals by photosynthetic microorganisms

Milano,

Giotta,

Lambreva

2024

Plant Physiology and Biochemistry

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Acute toxicity of nanoscale zeolitic imidazolate framework 8 (ZIF-8) to saltwater planktonic species Artemia salina and Nannochloropsis oculata

Cited by 2 publications

References 66 publications

Carboplatin‐loaded zeolitic imidazolate framework‐8: Induction of antiproliferative activity and apoptosis in breast cancer cell

Carboplatin‐loaded zeolitic imidazolate framework‐8: Induction of antiproliferative activity and apoptosis in breast cancer cell

Perspectives on nanomaterial-empowered bioremediation of heavy metals by photosynthetic microorganisms

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