Acute toxicity of polybrominated diphenyl ethers (PBDEs) for turbot (Psetta maxima) early life stages (ELS)

Mhadhbi, Lazhar; Fumega, J.; Boumaïza, Moncef; Beiras, Ricardo

doi:10.1007/s11356-011-0602-5

Cited by 51 publications

(15 citation statements)

References 38 publications

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“…No studies were found in the literature on the effect of PBDE on chitobiase activity. However, our results are consistent with those of Mhadhbi et al (2012) Similarly, Breitholtz and Wollenberger (2003), studying the larval Table 3 Univariate analyses of variance (ANOVA) investigating variations in chitinolytic enzymes activities in Gammarus pulex according to PBDE congener and concentrations and gammarid gender (p-values in bold indicate significant effects of the considered parameter). , respectively).…”

Section: Dose-and Congener-dependent Impact Of Pbdessupporting

confidence: 89%

Effects of two PBDE congeners on the moulting enzymes of the freshwater amphipod Gammarus pulex

Gismondi

Thomé

2014

Environmental Pollution

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a b s t r a c tPolybrominated diphenyl ethers (PBDEs) are abundant in aquatic environment. However, only few studies have investigated their impacts on freshwater invertebrates. This work aimed to study the effects of BDE-47 and BDE-99 congeners on the chitobiase and chitinolytic enzymes activities of the freshwater amphipod Gammarus pulex, according to gender, PBDE concentration and time of exposure. In addition, the bioaccumulation of BDE-47 and BDE-99 were measured. Results revealed that females have bioaccumulated more PBDE than males, and BDE-99 was more accumulated than BDE-47. PBDE exposures for 96 h have caused chitobiase and chitinolytic enzymes inhibition. This study not only indicate the importance of taking into account various confounding factors (gender, congeners, concentration) to understand PBDE effects, but underline also disruptions of molting enzymes activities. These disturbances suggest effects on the gammarid development and reproduction, and consequently effects on the gammarid population, and on a larger scale, a dysfunction of the ecosystem.

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Section: Dose-and Congener-dependent Impact Of Pbdessupporting

confidence: 89%

Effects of two PBDE congeners on the moulting enzymes of the freshwater amphipod Gammarus pulex

Gismondi

Thomé

2014

Environmental Pollution

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“…Of course, more detail studies are needed to verify the hypothesis. Previous studies reported that BDE47 was cytotoxic to differentiated cells or stem cells, and toxic to development [10,13], but little is about the mechanism of the BDE47 on the germ cells. Our data suggested that BDE47 induced apoptosis of early leptotene spermatocytes and thus disrupted the spermatogenesis in rat probably due to the deduced expressions of some mitochondrial proteins.…”

Section: Discussionmentioning

confidence: 99%

“…As a result, the levels of PBDEs and their residues in the environment and human tissues have increased in recent decades. Of all PBDEs, 2,2 ,4,4 -tetrabromodiphenyl ether (BDE47) was one of the most prevalent congeners in animal and human tissues [9,10].…”

Section: Introductionmentioning

confidence: 99%

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2,2′,4,4′-Tetrabromodiphenyl ether disrupts spermatogenesis, impairs mitochondrial function and induces apoptosis of early leptotene spermatocytes in rats

Huang

Cui

Guo

et al. 2015

Reproductive Toxicology

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“…Mhadhbi et al (2012) reported on the acute toxicity of PBDEs on embryo-larval He et al (2011) showed that long-term chronic exposure to deca-BDE significantly reduced the gonadosomatic index, sperm density, and sperm motility in zebrafish (Danio rerio) as well as retarded their motor neuron development and locomotion behavior (p < 0.05).…”

Section: Toxicity Of Pbdes In Aquatic Organismsmentioning

confidence: 99%

An overview of polybrominated diphenyl ethers (PBDEs) in the marine environment

Lee

Kim

2015

Ocean Sci. J.

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 Polybrominated diphenyl ethers (PBDEs), which are used extensively as brominated flame retardants, are found ubiquitously in marine environments worldwide. In this paper, we review all available data on the occurrence and trends of PBDEs in marine environments. PBDE levels in different marine environmental compartments vary from nanograms per gram to micrograms per gram, and differ widely, depending on the exposed species and the collection site. The PBDE congener profiles in biota, which are dominated by the lower brominated congeners, such as BDE-47 and BDE-99, are different from those in sediments, where BDE-209 is dominant. Temporal trends in PBDE levels in sediment cores vary considerably, depending on the region or country studied, with possible correlations with the historic and current use of PBDEs. Low brominated BDE congeners have the potential for bioaccumulation in marine organisms, but BDE-209 has a very low potential for bioaccumulating within the marine food web. The toxicological effects of PBDEs on marine organisms are largely unknown. However, PBDE isomers may be sufficient to elicit adverse effects in some marine organisms. Here, we discuss naturally occurring brominated diphenyl ethers and recommend further research to improve future monitoring.

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Acute toxicity of polybrominated diphenyl ethers (PBDEs) for turbot (Psetta maxima) early life stages (ELS)

Abstract: In the perspective of risk assessment, ELS endpoints provide rapid, cost-effective and ecologically relevant information, and links should be sought between these short-term tests and effects of long-term exposures in more realistic scenarios.

Cited by 51 publications

References 38 publications

Effects of two PBDE congeners on the moulting enzymes of the freshwater amphipod Gammarus pulex

Effects of two PBDE congeners on the moulting enzymes of the freshwater amphipod Gammarus pulex

2,2′,4,4′-Tetrabromodiphenyl ether disrupts spermatogenesis, impairs mitochondrial function and induces apoptosis of early leptotene spermatocytes in rats

An overview of polybrominated diphenyl ethers (PBDEs) in the marine environment

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