Acute Toxicity Profile of 1-Butyl-3-Methylimidazolium Chloride

Landry, Timothy D.; Brooks, Keith J.; Poché, David M.; Woolhiser, Michael R.

doi:10.1007/s00128-005-0620-4

Cited by 55 publications

(58 citation statements)

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“…The extent of NBuPy-Cl absorption after dermal application was affected by the nature of the vehicle. This is similar to observations with Bmim-Cl (Landry et al, 2005;Sipes et al, 2008). With a more hydrophobic vehicle (DMF), NBuPy-Cl was absorbed more extensively.…”

Section: Discussionsupporting

confidence: 87%

“…Ranke et al (2004) investigated the toxicity of imidazolium ionic liquids on leukemia and glioma rat cell lines and found these ILs were more toxic than conventional solvents, such as acetone and acetonitrile. One IL, 1-butyl-3-methylimidazolium chloride (Bmim-Cl), has been shown to cause dermal irritation when applied topically to rats but produced only minimal contact sensitization when evaluated in the mouse local lymph node assay (Landry et al, 2005). Systemic toxicity was also observed in these animals when Bmim-Cl was applied in a hydrophobic vehicle.…”

mentioning

confidence: 99%

“…Systemic toxicity was also observed in these animals when Bmim-Cl was applied in a hydrophobic vehicle. In a study by Landry et al (2005), the acute single oral dose LD 50 of Bmim-Cl was reported to be 550 mg/kg.…”

mentioning

confidence: 99%

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Characterization of the Disposition and Toxicokinetics ofN-Butylpyridinium Chloride in Male F-344 Rats and Female B6C3F1 Mice and Its Transport by Organic Cation Transporter 2

Cheng¹,

Wright²,

Hooth³

et al. 2009

Drug Metab Dispos

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Section: Discussionsupporting

confidence: 87%

mentioning

confidence: 99%

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Characterization of the Disposition and Toxicokinetics ofN-Butylpyridinium Chloride in Male F-344 Rats and Female B6C3F1 Mice and Its Transport by Organic Cation Transporter 2

Cheng¹,

Wright²,

Hooth³

et al. 2009

Drug Metab Dispos

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“…The selection of doses was based on the acute oral LD 50 of 550 mg/kg b.wt. in female F-344 rats reported by Landry et al (2005). In the studies reported herein, subtoxic doses of 50 mg/kg (0.1 ϫ LD 50 ), 5 mg/kg (0.01 ϫ LD 50 ), and 0.5 mg/kg (0.001 ϫ LD 50 ) were chosen to assess the effect of dose on the rate and route of excretion after oral administration.…”

Section: Figmentioning

confidence: 99%

The Effects of Dose and Route on the Toxicokinetics and Disposition of 1-Butyl-3-methylimidazolium Chloride in Male F-344 Rats and Female B6C3F1 Mice

Sipes¹,

Knudsen²,

Kuester³

2007

Drug Metab Dispos

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ABSTRACT:These studies characterize the effect of dose and route of administration on the disposition and elimination of the ionic liquid, 1-butyl-3-methylimidazolium chloride (Bmim-Cl). After i.v. (5 mg/ kg) or oral (50 mg/kg) administration to male F-344 rats [14 C]BmimCl detected in blood decreased rapidly. Clearance rates from the blood after i.v. and oral administration were similar (7.4 and 11.9 ml/min, respectively). Systemic bioavailability was determined to be 62.1% of a 50 mg/kg dose in rats. Urinary excretion of the parent compound by rats was the major route of elimination (i.v.: 91% in 24 h; oral: 55-74% in 24 h). The rates and routes of elimination were not affected by escalation of dose (0.5-50 mg/kg) or repeated oral administration (five daily administrations, 50 mg/kg) and were similar in male rats and B6C3F1 female mice (86-95% of dose eliminated in 24 h). Apparent systemic exposure to Bmim-Cl after dermal administration was dependent upon vehicle, as assessed by the percentage of dose eliminated in urine after application in a particular vehicle (water: 1%; ethanol/water: 3%; and dimethylformamide/water: 13% of dose). Regardless of gender, species, dose, route, or number of exposures, high-pressure liquid chromatography-UV/visible-radiometric analyses of urine samples showed a single peak that coeluted with the Bmim-Cl standard. These studies illustrate that systemic bioavailability of Bmim-Cl is high, tissue disposition and metabolism are negligible, and absorbed compound is extensively extracted by the kidney and eliminated in the urine as the parent compound.

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“…At the highest dose administered (2000 mg/kg), animals exhibited hypoactivity and abnormal posture prior to death within less than 24 hours after dose administration. Gross necropsy revealed discoloration of the intestines (Landry et al,2005).…”

Section: Acute Oralmentioning

confidence: 99%

Environmental Health Assessment for Work Unit RM 08-03, Ammonium Perchlorate Alternatives (Ionic Liquids)

Eck¹

2010

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Acute Toxicity Profile of 1-Butyl-3-Methylimidazolium Chloride

Cited by 55 publications

References 0 publications

Characterization of the Disposition and Toxicokinetics ofN-Butylpyridinium Chloride in Male F-344 Rats and Female B6C3F1 Mice and Its Transport by Organic Cation Transporter 2

Characterization of the Disposition and Toxicokinetics ofN-Butylpyridinium Chloride in Male F-344 Rats and Female B6C3F1 Mice and Its Transport by Organic Cation Transporter 2

The Effects of Dose and Route on the Toxicokinetics and Disposition of 1-Butyl-3-methylimidazolium Chloride in Male F-344 Rats and Female B6C3F1 Mice

Environmental Health Assessment for Work Unit RM 08-03, Ammonium Perchlorate Alternatives (Ionic Liquids)

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