Acute toxicity study of a polysaccharide based hydrogel from linseed for potential use in drug delivery system

Abstract

Linseed hydrogel (LSH) was evaluated by acute toxicity for its potential application in oral drug delivery design. White albino mice and rabbits were divided in four groups (I-IV) and different doses of LSH (1, 2 and 5 g/kg body weight) were given except to the control group (I) that was left untreated. Rabbits were monitored for eye irritation, acute dermal toxicity and primary dermal irritation, whereas, body weight, food and water consumption, hematology and clinical biochemistry, gross necropsy and histopathology of vital organs were scrutinized in mice. LSH was considered safe after eye irritation test as no adverse signs or symptoms were seen in the eye. In dermal toxicity and irritation study, skin of treated rabbits was found normal in color without any edema or erythema. After oral administration, there was no sign of any abnormalities in treated group animals (II-IV). The hematology and clinical biochemistry of treated group animals was comparable with the control group. Histopathology of vital organs has not shown any lesion or abnormalities. In the light of these outcomes, it can be concluded that LSH is not a hazardous biomaterial and could be incorporated as an excipient in oral and dermal preparations.

β-cyclodextrin chitosan-based hydrogels with tunable pH-responsive properties for controlled release of acyclovir: design, characterization, safety, and pharmacokinetic evaluation

“…Liver lobules of group B were present with clear dividing lines, similar to group A. No hypertrophy was obvious on hepatic sinusoid and no neutrophil, lymphocyte, or macrophage infiltration was observed, indicating lack of any toxicity (Haseeb et al, 2018). Spleen sinus was absolutely normal, without any evidence of toxicity or pathological alteration in both control and hydrogel treated group.…”

Fabrication, Characterization and Toxicity Evaluation of Chemically Cross linked Polymeric Network for Sustained Delivery of Metoprolol Tartrate

“…The lack of a vital dissimilarity in liver enzymes level displays the protective hepatotoxic state, and absence of significant differences in creatinine and urea also demonstrate the nephroprotective property of QSM-co-AAm hydrogels on the health of rabbits. The complete blood, renal, liver and lipid profiles were similar to the control group and appeared in normal range, which demonstrated safety profile of QSM-co-AAm hydrogels [ 31 ].…”

pH Sensitive Pluronic Acid/Agarose-Hydrogels as Controlled Drug Delivery Carriers: Design, Characterization and Toxicity Evaluation

“…The results of the hematology and biochemical analysis of the control and test group rabbits are shown in Table 5. The complete analysis of the blood indicates that all the values were found within a normal range [81]. Moreover, as shown in Figure 11, histopathological studies revealed no significant alterations or abnormality in the tissue structures of the rabbits treated with hydrogel when compared with the control groups [82].…”

“…The results of the hematology and biochemical analysis of the control and test group rabbits are shown in Table 5. The complete analysis of the blood indicates that all the values were found within a normal range [81].…”