Acute Toxicity to Rats and Trout with a Focus on Inhalation and Aquatic Exposures

Delistraty, Damon

doi:10.1006/eesa.1999.1906

Cited by 32 publications

(10 citation statements)

References 23 publications

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“…The low toxicity of fenitrothion to mammals may be misleading at this point in terms of ecotoxicology and lead to extrapolation problems to aquatic species. Delistraty (2000) in a study to examine the relationships of physicochemical properties and acute toxicity endpoints of 231 chemicals in rats and trout concluded that the trout aquatic LC 50 was predicted from rat inhalation LC 50 with moderate success. Therefore such data are useful in ecological risk assessment but there are limitations and uncertainties.…”

Section: Resultsmentioning

confidence: 99%

Investigation of acute toxicity of fenitrothion on guppies Poecilia reticulata

Sarıkaya¹,

Selvı²,

Koçak³

et al. 2007

J of Applied Toxicology

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Fenitrothion, an organophosphothionate insecticide (CAS number: 122-14-5) and potential toxic pollutant contaminating aquatic ecosystems, was investigated in the present study for acute toxicity. Guppy fish (Poecilia reticulata) were selected for the bioassay experiments. The experiments were repeated three times and the 96 h LC(50) was determined for the guppies. The static test method of acute toxicity test was used. The water temperature was regulated at 23 +/- 1 degrees C. In addition, behavioral changes at each fenitrothion concentration were observed for the individual fish. Data obtained from the fenitrothion acute toxicity tests were evaluated using the probit analysis statistical method. The 96 h LC(50) value for guppy was estimated as 3.28 mg l(-1). Values in the range of microg l(-1) and mg l(-1) have been reported for various other fish species.

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Section: Resultsmentioning

confidence: 99%

Investigation of acute toxicity of fenitrothion on guppies Poecilia reticulata

Sarıkaya¹,

Selvı²,

Koçak³

et al. 2007

J of Applied Toxicology

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“…On the other hand, the greater number of distinct TEFs among corresponding congeners for mammals vs. fish (Tl or T2 vs. T3), mammals vs. birds (Tl or T2 vs. T4), or for fish vs. birds (T3 vs. T4) contributed to differences in soil TEQs, based on these TEF schemes (Table VI). Many of the dissimilarities in TEF schemes among various classes of receptors (i.e., mammalian, fish, bird) are likely due to phylogenetic distinctions and associated toxicokinetic and toxicodynamic variations [32]. If these toxicokinetic differences were taken into account, differences in TEFs across species and endpoints may be minimized [7].…”

Section: Tef Methodsmentioning

confidence: 99%

Influence of toxic equivalency factor scheme and method for treating non‐detect values on soil dioxin levels

Delistraty

Laflamme

2001

Toxicological & Environmental Chemistry

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The purpose of this study was to evaluate the influence of four toxic equivalency factor (TEF) schemes (i.e., human/mammalian [Tl, T2], fish [T3], bird [T4]) and three substitution methods for treating non-detect (ND) data (i.e., ND = 0 [Nl], ND = 0.5 DL [N2], ND = DL [N3] where DL = detection limit) on polychlorinated dibenzo-p-dioxin (PCDD) and dibenzofuran (PCDF) toxic equivalent (TEQ) concentrations in agricultural soils in Washington state (USA). Soil TEQs (n = 54) were determined for 12 combinations of TEF and ND levels and log-transformed for statistical analysis. Significant bivariate correlations (Bonferroni p < .05) were observed for TEQ among all TEF levels within each ND level and between N2 and N3 within and among TEF levels. A two-factor ANOVA demonstrated significant effects (p < .0001) for TEF, ND, and their interaction. Mean TEQ at T3 was significantly lower (p < .05) than other TEF levels at Nl, whereas mean TEQ at T4 was significantly higher (p < .05) than Tl both at N2 and N3. Mean TEQs at all ND levels differed significantly (p < .05) at each TEF level with Nl < N2 < N3. These results illustrate that TEF and ND methods can notably impact calculations for low concentrations of soil dioxin.

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“…Wolf et al (2004) observed that after establishing a lethal narcosis mechanism through the inhalation exposure route, a compound's oral toxicity can be reliably estimated. The toxicity related with the exposure routes has been observed by many people (Klaassen and Rozman 1991;Delistraty 1999Delistraty , 2000.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Critical Body Residues and Modes of Toxic Action Based on Injection and Aquatic Exposure in Fish

Wen

Qin

et al. 2015

Water Air Soil Pollut

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The internal concentration represented by the critical body residue (CBR) is an ideal indicator to reflect the intrinsic toxicity of a chemical. Whilst some studies have been performed on CBR, the effect of exposure route on internal toxicity has not been investigated for fish. In this paper, acute toxicity data to fish comprising LC50 and LD50 values were used to investigate CBR. The results showed that exposure route can significantly affect the internal concentration. LD50 and CBR calculated from LC50 and BCF both vary independently of hydrophobicity as expressed by log Kow; conversely, LC50 is related to log Kow. A poor relationship was observed between LC50 and LD50, but the relationship can be improved significantly by introduction of log Kow because log CBR is positively related to log LD50. The parallel relationship of log CBR-log Kow and log LD50-log Kow indicates that LD50 does not reflect the actual internal concentration. The average LD50 is close to the average CBR for less inert and Electronic supplementary material The online version of this article

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Acute Toxicity to Rats and Trout with a Focus on Inhalation and Aquatic Exposures

Cited by 32 publications

References 23 publications

Investigation of acute toxicity of fenitrothion on guppies Poecilia reticulata

Investigation of acute toxicity of fenitrothion on guppies Poecilia reticulata

Influence of toxic equivalency factor scheme and method for treating non‐detect values on soil dioxin levels

Investigation of Critical Body Residues and Modes of Toxic Action Based on Injection and Aquatic Exposure in Fish

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