Acute Toxicological Evaluations of the Methanol Leaf Extract of Justicia flava (Vahl) Acanthaceae in Mouse Models

Bafor, Enitome E.; Ukpebor, Faith; Omoruyi, Osemelomen; Ochoyama, Ejiro; Odega, Kevin

doi:10.26538/tjnpr/v3i4.6

Cited by 5 publications

(6 citation statements)

References 13 publications

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“…This efficacy is comparable to the reduction in DNA damage and enhanced cell division in rats exposed to petroleum-tainted feed and administered with standard ascorbic acid. In fact, previous studies presented the medical ability of this plant [27]. Similarly, this observation is consistent with the papers where JFME was involved in reducing the damage caused by petroleum-tainted diet in the liver of rats [37].…”

Section: Resultssupporting

confidence: 91%

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Effect of Methanolic Extract of Justicia Flava on Petroleum-Induced Reduced Cell Division and DNA Damage

Achuba

Mordi

2019

Galician med. j.

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The objective of this research was to determine the import of Justicia flava methanolic extract against petroleum-stimulated reduced cell division and DNA fragmentation. Materials and Methods. Ninety rats were distributed and treated as follows for thirty days: Group A - normal diet; Group B - normal feed + 100mg/kg bwt of Justicia flava methanolic extract; Group C - normal feed + 200mg/kg bwt of Justicia flava methanolic extract; Group D - normal feed + 300mg/kg bwt of Justicia flava methanolic extract; Group E - normal feed + 250 mg/kg bwt of standard ascorbic acid; Group F - crude oil-tainted feed; Group G - crude oil-tainted feed + 250 mg/kg bwt of standard ascorbic acid; Group H - crude oil-tainted feed + 100mg/kg bwt of Justicia flava methanolic extract; Group I - crude oil-tainted feed + 200mg/kg bwt of Justicia flava methanolic extract. After thirty days, the rats were sacrificed under chloroform sedation and the liver and kidney were collected for cellular analysis via standard protocols. Results. The results showed that administration of Justicia flava methanolic extract decreased petroleum-induced reduced cell division and DNA damage in the liver and kidney of experimental rats. Justicia flava methanolic extract is potent antidote for petroleum-induced DNA damage in the liver and kidney of rats. Conclusions. It is no doubt that ingestion of petroleum-tainted diet could culminate in DNA damage in organs and tissues of animals. However, the administration of Justicia flava methanolic extract was found to prevent this damage in renal and liver cells of experimental rats.

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Section: Resultssupporting

confidence: 91%

“…Moreover, various substances have been used as counter measures to crude oil toxicities. These substances include various vitamins [21,22,23,24] organic and inorganic substances [9,5,25] and various plant extracts [9,26,27]. A review of literature shows that there is one important plant with a lot of curative ability [27].…”

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confidence: 99%

Effect of Methanolic Extract of Justicia Flava on Petroleum-Induced Reduced Cell Division and DNA Damage

Achuba

Mordi

2019

Galician med. j.

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“…This is a pilot study that clearly shows the tocolytic potential of JF for human uterine contractility disorders. Previous safety studies on mice showed JF to be relatively safe, even at high doses of 5 g kg −1 (Bafor et al., 2019b). Our previous studies have also shown JF to have mild oestrogenic activities at low doses (Bafor et al., 2020), which is beneficial to its continued use on humans.…”

Section: Resultsmentioning

confidence: 98%

“…One other such plant of growing interest is Justicia flava . The leaves of J. flava are regularly used in the south of Nigeria to prevent miscarriages (Bafor, Ukpebor, Omoruyi, Ochoyama, & Odega, 2019) possibly through myometrial contractility inhibition. For this reason, the plant was selected and explored extensively on mouse models for its activity on uterine contractility and the female reproductive system (Bafor et al., 2020; Bafor et al., 2019a).…”

Section: Introductionmentioning

confidence: 99%

Justicia flava leaf extract potently relaxes pregnant human myometrial contractility: a lead plant for drug discovery of new tocolytic drugs

Bafor

Prendergast

Wray

2020

Experimental Physiology

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In the search for new potent therapies for preterm labour, Justicia flava leaf extract (JF) was previously shown to potently inhibit uterine contractility in both pregnant and non-pregnant mouse uterus. This study took the investigation a step further and investigated the activity of JF on pregnant human myometrial contractility. JF potently inhibited human myometrial contractility in a concentration-dependent manner. This pilot study provides evidence that JF should be further investigated as a lead plant in the drug discovery of new uterine relaxants.

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“…Signs for toxic manifestations like abnormal motor activity, alteration in water or food intake, writhing, straub reaction, sedation, diarrhoea, piloerection, opisthotonus, exophthalmos and tremors were observed for in all groups [15].…”

Section: Observation and Examination Methodsmentioning

confidence: 94%

Stachytarpheta indica Leaf Extract: Oral Acute Toxicity, In vitro Phytochemical and Antimicrobial Potentials

Musa

Ogbiko

Dabai

et al. 2019

EJCS

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This study was designed to ascertain the safety profile as well as explore new antimicrobial agents from the methanol leaf extract of Stachytarpheta indica. The methanol extract was prepared and screened for its phytochemical composition, oral acute toxicity profile as well as challenged with common pathogenic microorganisms for its antimicrobial activities using standard procedures. The phytochemical analysis revealed the presence of various pharmaceutically active secondary metabolites like alkaloids, saponins, carbohydrate, cardiac glycosides, terpenoid, tannin, anthraquinones, phenolics and flavonoid. P. aeruginosa and S. aureus showed the best and least antibacterial activity respectively. The extract exhibited antifungal activity in a dose dependent manner with the inhibition more pronounced with A. niger than with C. albicans. The standard drugs ciprofloxacin and fluconazole exhibited a near 100% activity. There was no mortality at 8 g/kg p.o. after 24 hours and no sign of delayed toxicity or mortality after 14 days of observation. There were no statistically significant differences (p > 0.05) observed in the examined organs as well as body weights in both 24 h and 14 d study. This research holds promise for the exploration of various potentially active secondary metabolites which would help in developing pharmaceuticals especially antimicrobial drugs as well as recommend the short-term oral administration of the extract up to a dose of 8 g/kg body weight.

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Acute Toxicological Evaluations of the Methanol Leaf Extract of Justicia flava (Vahl) Acanthaceae in Mouse Models

Cited by 5 publications

References 13 publications

Effect of Methanolic Extract of Justicia Flava on Petroleum-Induced Reduced Cell Division and DNA Damage

Effect of Methanolic Extract of Justicia Flava on Petroleum-Induced Reduced Cell Division and DNA Damage

Justicia flava leaf extract potently relaxes pregnant human myometrial contractility: a lead plant for drug discovery of new tocolytic drugs

Stachytarpheta indica Leaf Extract: Oral Acute Toxicity, In vitro Phytochemical and Antimicrobial Potentials

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