Acute Transient Macular Edema after Uneventful Cataract Surgery

Beisekeeva, J. S.; Bezrukov, A. V.; Kochergin, S.A.; Samoylenko, A. I.

doi:10.18008/1816-5095-2021-3-442-450

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…There is a group of congenital and acquired conditions that show no dye leakage from the retinal or choroidal capillaries in fluorescent angiography (FA) but on ОCТ, there is fluid accumulation in the outer or inner retinal layers [65]. This may occur on the first day after uncomplicated cataract surgery, probably due to cefuroxime toxicity [66] and as a side effect of nicotinic acid and drugs from taxans group. The fact that these resolve without treatment during a week after surgery or after drug withdrawal is evidence for the presence of interstitial outflow routes in the retina.…”

Section: Figure 3 Calculation Elements Of Pressure Gradients and Prob...mentioning

confidence: 99%

Hydrostatic Pressure Gradients and a New Membrane-glymphatic Theory of Primary Glaucoma

Beisekeeva¹,

Kulumbetova²,

Beisekeev³

et al. 2022

IJOVS

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The paper describes a novel theory of primary glaucoma etiopathogenesis based on a new understanding of the glymphatic system of the eye. Glymphatic flow routes of the eye include the vitreous body, uveal tract, paravascular spaces, and the retina. There are different pressure gradients of the intraocular fluid flow within the divided central channel of the vitreous body. In normal conditions above the foveola there is highly positive pressure gradient whereas above the optic disc it is 3 times lower. The retinal pigment epithelium is responsible for water and metabolic exchanges between choroid and the vitreous, therefore may contribute to intra-ocular fluid accumulation. Impairment of the outer blood-ocular and/or bloodaqueous barriers is the key pathogenic element of glaucoma including secondary forms due to uveitis. A disbalance of the pressure gradients above the macula and above the optic disc leads to fluid accumulation above the latter. An abundant intraretinal fluid flow through the glymphatic pathways in the outer and inner plexiform layers, formed by Muller cell processes, contributes to accumulation of the interstitial fluid before the lamina cribrosa. Excessive interstitial fluid from the retina passes not only through the retinal pigment epithelium to choroid but also through paravascular spaces to the optic disc cup and discharges partly back to the vitreous body through the prevascular vitreous fissures. There is an interstitial fluid flow existing through paravascular spaces, the plexiform layers of retina and along the axons of ganglion cells to the optic nerve and its sheath where excessive fluid is absorbed into the subarachnoid space. The RPE plays a major role in glaucoma etiopahogenesis, probably acting as a regulator of fluid transport in the eye.

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Section: Figure 3 Calculation Elements Of Pressure Gradients and Prob...mentioning

confidence: 99%

Hydrostatic Pressure Gradients and a New Membrane-glymphatic Theory of Primary Glaucoma

Beisekeeva¹,

Kulumbetova²,

Beisekeev³

et al. 2022

IJOVS

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The Incidence and the Clinical Course of Retinal Complications of Intracameral Cefuroxime in Cataract Surgery

Svetozarskiy¹,

Андреев²,

Shvaikin³

2022

Oftalʹmologiâ

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Aim. To determine the incidence and the clinical course of retinal complications of intracameral administration of cefuroxime in minimally invasive cataract surgery.Methods. From 2016 to 2021, a prospective clinical study was conducted at the Volga District Medical Center of the Federal Medical and Biological Agency of Russia, which included patients with cataract in one or two eyes to be surgically treated. All patients received 1 mg of cefuroxime injected into the anterior chamber at the end of surgery. All patients underwent ophthalmological examination including evaluation of best corrected visual acuity with determination of logarithm of minimum angle of resolution (logMAR), tonometry, biomicroscopy, and ophthalmoscopy. Each patient before and the day after surgery underwent optical coherence tomography of the retina on a spectral optical tomograph RTVue-100 (Optovue). The dynamics of the condition was evaluated on days 3 and 7 after surgery.Results. Five cases of retinal complications of intracameral cefuroxime injection were identified during the 5-year study period. According to data of optical coherence tomography, retinal edema was localized in the internal nuclear layer of the retina, and the height of serous retinal detachment in the fovea area on the next day after surgery was 315.0 ± 11.0 µm and reduced statistically significantly to 59.8 ± 42.3 µm on the 3rd day after the intervention (p = 0.043). One week later, all patients had complete retinal adherence and recovery of visual function. Retinal edema did not recur in the long term after surgery.Conclusion. Serous retinal detachment with macular edema is the most common clinically relevant complication of intracameral antibiotic prophylaxis, which develops both in compliance with the dilution protocol and in overdose, and has a favourable prognosis.

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Acute Transient Macular Edema after Uneventful Cataract Surgery

Cited by 2 publications

References 30 publications

Hydrostatic Pressure Gradients and a New Membrane-glymphatic Theory of Primary Glaucoma

Hydrostatic Pressure Gradients and a New Membrane-glymphatic Theory of Primary Glaucoma

The Incidence and the Clinical Course of Retinal Complications of Intracameral Cefuroxime in Cataract Surgery

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