Acute Tubulointerstitial Nephritis in Rosai-Dorfman Disease Mimicking IgG4-related Disease

Kurahashi, Satoshi; Toda, Naohiro; Fujita, Masaaki; Tanigaki, Katsuya; Takeoka, Jun; Hirashima, Hisako; Muso, Eri; Io, Katsuhiro; Sakurai, Takaki; Komiya, Tohru

doi:10.2169/internalmedicine.8046-21

Cited by 4 publications

(1 citation statement)

References 19 publications

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“… 2 , 10 These features may also help distinguished Sjögren’s syndrome from RRD of the salivary glands, as the former lacks histiocytic infiltrates in tissue. 20 …”

Section: Literature Reviewmentioning

confidence: 99%

Immunoglobulin G4-Associated Rosai–Dorfman Disease: Report of 3 Cases

Gallo¹,

Paira²,

Hernández-Molina³

et al. 2023

Eur J Rheumatol

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Rosai–Dorfman disease is characterized by dilated lymph node sinuses filled with lymphocytes, plasma cells, and histiocytes. Many of these histiocytes classically exhibit emperipolesis of lymphocytes and plasma cells. Abundant immunoglobulin G4+ plasma cells occur in some cases, and a potential relationship with immunoglobulin G4-related disease has been suggested. Here, we report 3 cases of immunoglobulin G4-associated Rosai–Dorfman disease. Immunoglobulin G4-related disease was suspected based on immunoglobulin G4+ plasma cell infiltration, but the final diagnosis was immunoglobulin G4-associated Rosai–Dorfman disease. At present, the evidence does not support a link between immunoglobulin G4-associated Rosai–Dorfman disease and immunoglobulin G4-related disease, and one condition should not be considered part of the spectrum of the other. We believe it is of paramount importance to increase the awareness of immunoglobulin G4-associated Rosai–Dorfman disease for pathologists who interpret the biopsies and clinicians who integrate the diagnosis and treat such patients to not overdiagnose immunoglobulin G4-related disease.

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“… 2 , 10 These features may also help distinguished Sjögren’s syndrome from RRD of the salivary glands, as the former lacks histiocytic infiltrates in tissue. 20 …”

Section: Literature Reviewmentioning

confidence: 99%

Immunoglobulin G4-Associated Rosai–Dorfman Disease: Report of 3 Cases

Gallo¹,

Paira²,

Hernández-Molina³

et al. 2023

Eur J Rheumatol

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Proliferative features of IgG4-related disease

Katz,

Hernandez-Barco,

Palumbo

et al. 2024

The Lancet Rheumatology

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Recent advances in IgG4-related kidney disease

Kawano

Saeki

Ubara

et al. 2022

Modern Rheumatology

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Recent advances in the management and understanding of IgG4-related kidney disease (RKD) have emphasized the importance of urgent treatment in IgG4-related tubulointerstitial nephritis. On the other hand, to avoid long term glucocorticoid toxicity, strategies for early withdrawal of steroid or combination of immunosuppressants, such as rituximab, and the minimum dose of steroid have been pursued. However, disease recurrence after reducing or stopping steroid therapy hampers early withdrawal of glucocorticoid maintenance therapy. In addition, knowledge has accumulated in diagnostic approaches including differential diagnosis of anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis, idiopathic multicentric Castleman’s disease, and Rosai-Dorfman disease with kidney lesion, which leads to earlier and precise diagnosis of IgG4-RKD. This review summarizes recent progress in the differential diagnosis of IgG4-RKD and related treatment strategies, and recent topics of hypocomplementemia, membranous glomerulonephritis, and IgG4-related pyelitis and periureteral lesion.

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Acute Tubulointerstitial Nephritis in Rosai-Dorfman Disease Mimicking IgG4-related Disease

Cited by 4 publications

References 19 publications

Immunoglobulin G4-Associated Rosai–Dorfman Disease: Report of 3 Cases

Immunoglobulin G4-Associated Rosai–Dorfman Disease: Report of 3 Cases

Proliferative features of IgG4-related disease

Recent advances in IgG4-related kidney disease

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