Acute undifferentiated febrile illness: Protocol in emergency department

Subramanyam, V; Kaeley, Nidhi; Kumar, Manish; Pandey, Subodh K; Bhardwaj, Bhanu; Reddy, Konda Sireesha

doi:10.4103/jfmpc.jfmpc_214_19

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…During an outbreak in Sierra Leone in 2019, Proesmans et al Reported that dengue virus (DENV) infection accounted for 5% of acute fever etiologies and acute chikungunya virus infection for 39% [4]. In New York in 2020, Subramanyam et al reported that acute fever represented 15% of complaints in the elderly and around 5% in young people in the emergency room [5]. In Asia in 2014, Susilawati et al reported that the causes of acute fever are undiagnosed in 8% of cases [6].…”

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confidence: 99%

Acute Fevers in the Medical Unit of the Medical-Surgical Emergency Department of the Donka National Hospital

Sylla,

Kake,

Wann

et al. 2023

OJIM

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Introduction: Fever is a high core temperature ≥ 37.5˚C in the morning and 37.8˚C in the evening. It is acute when it evolves from 0 to 20 days. Very common in clinical practice, the etiological diagnosis, particularly in developing and tropical countries, is often a challenge for clinicians due to their diversity and the limited availability of diagnostic tools. There is a wide spectrum of etiological diagnoses including infectious causes and non-infectious causes. The aim of this study was to investigate the etiology of fevers acute at the medical unit in the medico-surgical emergency department of the Donka National Hospital. Methods: This was a descriptive cross-sectional study lasting 03 months (January 01, 2022 to March 31, 2022). We included in this study all patients seen in the medical unit, whose age ≥ 18 years, without distinction of sex, from any origin, with an axillary temperature ≥ 37.5˚C in the morning and 37.8˚C in the evening, evolving from 0 to 20 days, hospitalized or followed on an outpatient basis, and having given verbal consent. Results: Of a total of 1087 patients seen, 466 had an acute fever. The mean age was 40.04 ± 18.91 years (18 and 96 years). The female sex (58.15%) was predominant with a sex ratio of 0.72. Malaria (50.86%) was the main diagnosis. The treatment consisted of compressed paracetamol (59.01%), arthemether + lumefantrine (50.85%). Conclusion: The incidence of acute fevers is high in the medical unit of the medico-surgical emergency department of the Donka National Hospital. Malaria was the main pathology. Treatment was etiological and symptomatic. This high incidence could be explained by the fact that Guinea is an endemic malaria zone. A study taking into account other etiological factors would be of great interest.

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Section: Introductionmentioning

confidence: 99%

Acute Fevers in the Medical Unit of the Medical-Surgical Emergency Department of the Donka National Hospital

Sylla,

Kake,

Wann

et al. 2023

OJIM

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Epidemiology of patients presenting to the emergency department with acute febrile illness in the summer months in Karachi, Pakistan: a cross-sectional study

Khan

Soomar

et al. 2023

Annals of Medicine &Amp; Surgery

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Background: Low and middle-income countries, including Pakistan, encounter many acute, undifferentiated fevers in their emergency departments (EDs), especially in the summer. There is a need to understand the prevalence and etiologies of fever to create sustainable risk stratification systems and better identification processes for more efficient treatments. This study aims to determine the patterns, causes, and outcomes of patients presenting to the ED with a fever in the summer months in Karachi, Pakistan. Patients and methods: This was a cross-sectional surveillance study conducted in the summers of 2017 and 2018 in the EDs of four tertiary care hospitals in Karachi, Pakistan. Patients 18 years of age and older, both males and females, that presented with a fever within 48 h were enrolled in the study. The study sample was 5034. Prior comorbidities, medication history, and treatment offered for the illness and diagnosis were noted. The data were stratified by years, that is, 2017–2018. A χ 2-test and a one-way analysis of variance test were applied to check the association between fever presentation in years and covariates. Results: Of the 5034 patients, 3045 (60.5%) presented in 2017 and 1989 (39.5%) presented in 2018. Almost half of the patients who presented with fever to the ED were between 25 and 44 years of age [2383 (47.3%)]. A majority of those presenting were male [3049 (60.6%)]. Most of the patients had a fever recorded between 101 and 102°F [1038 (20.6%)]. The most common accompanying symptoms were headache [2636 (52.4%)] and nausea and vomiting [2274 (45.2%)]. The majority of the patients were diagnosed as viral fever [2390 (47.5%)]. Patients were managed with antibiotics [3342 (66.4%)] and intravenous fluids [2521 (50.1%)] and a majority of patients were discharged [4677 (93.8%)]. Conclusions: Fever is a common presentation in the ED. Understanding the frequency of the causative agent will help improve diagnosis and the judicious use of antibiotics.

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Aptamer-guided Selective Delivery of Therapeutics to Breast Cancer Cells Expressing Specific Biomarkers

Pandey,

Parul,

Santhanam

2024

CCTR

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Cancer biomarkers or tumor-associated antigens (TAA) are the focus area of current research in cancer biology for diagnosis, prognosis, screening, and targeted treatments. Breast cancer is the second most common type of cancer, affecting women more than men. Conventional methods and antibody-targeted therapies are less effective and suffer systemic cytotoxicity, poor tissue sensitivity, low penetration capacity, and reduced accumulation of the drug in tumor cells that limit its application and sometimes result in treatment failure. Opting for aptamer-mediated targeted delivery of various anti-cancer agents (drugs, siRNA, miRNA, shRNA and peptides) could possibly overcome these limitations by utilizing aptamer as a targeting ligand. The purpose of this article is to review the novel indicative biomarkers of breast cancer and also describe current applications of aptamer-guided active targeting systems in breast cancer therapy in vivo and in vitro.

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Acute undifferentiated febrile illness: Protocol in emergency department

Cited by 3 publications

References 13 publications

Acute Fevers in the Medical Unit of the Medical-Surgical Emergency Department of the Donka National Hospital

Acute Fevers in the Medical Unit of the Medical-Surgical Emergency Department of the Donka National Hospital

Epidemiology of patients presenting to the emergency department with acute febrile illness in the summer months in Karachi, Pakistan: a cross-sectional study

Aptamer-guided Selective Delivery of Therapeutics to Breast Cancer Cells Expressing Specific Biomarkers

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