Acute Upper Gastrointestinal Bleeding: Comparison Between Recent Users and Nonusers of Nonsteroidal Anti-Inflammatory Drugs

Abstract

Recent NSAID users were found to bleed from ulcers, mostly duodenal, and to have H. pylori infection more frequently than UGI bleeders with a negative history of NSAID consumption. Alcohol abuse was also more common among NSAID users. The severity of bleeding and the outcome did not differ between the two groups.

Alcohol Abuse Increases Rebleeding Risk and Mortality in Patients with Non-variceal Upper Gastrointestinal Bleeding

“…Moreover, active bleeding was not associated with increased mortality risk in this study. The 6.0 % early mortality was acceptable and is in line with previously reported results [18,19].…”

Incidence and etiology of acute non‐malignant upper gastrointestinal bleeding in northern Greece

“…The vast majority of NSAID‐related ANMUGIB cases were a consequence of BPU, as seen in other studies, but the prevalence of bulbar location was in contrast to many previous studies 22,24,25 . However, it was supported by another Greek study 26 …”

“…22,24,25 However, it was supported by another Greek study. 26 An increase has been noticed in the proportion of BPU not attributed to Hp infection. 4 Sixty percent of BPU cases infected by Hp are in accord with a very recent study's results.…”

Systematic review: Helicobacter pylori and the risk of upper gastrointestinal bleeding risk in patients taking aspirin

“…Cohort studies 11,[15][16][17][18][19][20][21][22][23] Ten cohort studies were examined in detail. Five recruited patients who had clinical or endoscopic evidence of UGIB.…”