Acute Viral Enteritis and Exacerbations of Inflammatory Bowel Disease

Gebhard, Roger L.; Greenberg, Harry B.; Singh, Namita; Henry, Peter J.; Sharp, Harvey L.; Kaplan, Leo; Kapikian, Albert Z.

doi:10.1016/s0016-5085(82)80129-7

Cited by 52 publications

(19 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A 2009 stool study reported a 100% norovirus detection rate in all CD ( n = 1), UC ( n = 8) and control patients ( n = 9) . However, the possibility that acute viral diarrhoea could have mimicked a relapse of CD makes this result unreliable . Our meta‐analysis of two studies provides no evidence for an association of norovirus with CD (RR 0.767, 95% CI 0.518 to 1.134).…”

Section: Gastrointestinal Virusesmentioning

confidence: 67%

Current knowledge and systematic review of viruses associated with Crohn's disease

Wagner

Sim

Lee

et al. 2012

Reviews in Medical Virology

View full text Add to dashboard Cite

The aetiology of Crohn's disease (CD) is currently unknown. A viral trigger was proposed more than 40 years ago and has been the focus of many investigations. We summarised the current literature surrounding the association between viruses and CD and conducted a systematic review of all studies investigating this association quantitatively. Studies were identified by searching for 13 specific virus names or the general term 'virus' and 'Crohn's disease' in search engines PubMed and OVID. A total of 1315 studies were identified, of which 78 studies had a laboratory result. Of the 78, 46 case-control studies met all the inclusion criteria for forest plot analysis. The most common viruses studied were EBV, CMV and measles virus (MV). Forest plot analysis for each virus was carried out (fitted using random effects) and identified evidence of an association between CD and CMV (risk ratio [RR] 1.602, 95% confidence interval [CI] 1.069 to 2.400) with some suggestion that EBV may also be associated with CD (RR 1.366, 95% CI 0.996 to 1.873). However, there was evidence of large heterogeneity in the results from the identified studies for EBV. There was little evidence of an association with CD for MV, human herpes virus 6, human herpes virus 8, human simplex virus, varicella-zoster virus, mumps virus, Rubella virus, rotavirus, norovirus and adenovirus. There is still some question around whether CD is associated with the presence of a currently known virus.

show abstract

Section: Gastrointestinal Virusesmentioning

confidence: 67%

Current knowledge and systematic review of viruses associated with Crohn's disease

Wagner

Sim

Lee

et al. 2012

Reviews in Medical Virology

View full text Add to dashboard Cite

show abstract

“…Infectious diarrhoea is a known precipitant of relapses in inflammatory bowel disease 85 ,. 86 Patients with inflammatory bowel disease may be advised to avoid eating foods that are associated with an increased risk of transmitting pathogens known to cause gastroenteritis. Specifically, uncooked meat or raw eggs are best avoided.…”

mentioning

confidence: 99%

Nutrition and adult inflammatory bowel disease

Goh

O’Moráin

2003

Aliment Pharmacol Ther

215

142

View full text Add to dashboard Cite

Summary Major advances in the understanding of the aetio‐pathogenesis and genetics of inflammatory bowel disease have been accompanied by an escalation in the sophistication of immunomodulatory inflammatory bowel disease therapeutics. However, the basic ‘triple’ therapy (5‐aminosalicylates, corticosteroids, azathioprine) and nutrition have maintained their central role in the management of patients with inflammatory bowel disease over recent decades. This review provides an overview of the supportive and therapeutic perspectives of nutrition in adult inflammatory bowel disease. The objective of supportive nutrition is to correct malnutrition in terms of calorie intake or specific macro‐ or micronutrients. Of particular clinical relevance is deficiency in calcium, vitamin D, folate, vitamin B12 and zinc. There is justifiably a growing sense of unease amongst clinicians and patients with regard to the long‐term use of corticosteroids in inflammatory bowel disease. This, rather than arguments about efficacy, should be the catalyst for revisiting the use of enteral nutrition as primary treatment in Crohn's disease. Treatment failure is usually related to a failure to comply with enteral nutrition. Potential factors that militate against successful completion of enteral nutrition are feed palatability, inability to stay on a solid‐free diet for weeks, social inconvenience and transient feed‐related adverse reactions. Actions that can be taken to improve treatment outcome include the provision of good support from dietitians and clinicians for the duration of treatment and the subsequent ‘weaning’ period. There is evidence to support a gradual return to a normal diet through exclusion–re‐introduction or other dietary regimen following the completion of enteral nutrition to increase remission rates. We also review the evidence for emerging therapies, such as glutamine, growth factors and short‐chain fatty acids. The future may see the evolution of enteral nutrition into an important therapeutic strategy, and the design of a ‘Crohn's disease‐specific formulation' that is individually tailored, acceptable to patients, cost‐effective, free from adverse side‐effects and combines enteral nutrition with novel pre‐ and pro‐biotics and other factors.

show abstract

“…Only indigenous bacteria, Escherichia coli and Enterobacter species tested positive. Regarding viral infections, cytomegalovirus, norovirus or rotavirus are also reported as risk factors for CD being refractory (12,13). Negative antigenemia test against cytomegalovirus (C-7 HRP) was found.…”

Section: Discussionmentioning

confidence: 95%

Combination Therapy with Adalimumab Plus Intensive Granulocyte and Monocyte Adsorptive Apheresis Induced Clinical Remission in a Crohn's Disease Patient with the Loss of Response to Scheduled Adalimumab Maintenance Therapy: A Case Report

et al. 2012

View full text Add to dashboard Cite

A 21-year-old Caucasian man with a diagnosis of Crohn's disease (CD) at the age of 14 was admitted to our hospital due to CD flare-up while under scheduled adalimumab (ADA) maintenance therapy. His symptoms remained virtually unchanged following high dose corticosteroid therapy. Seven days later, combination therapy with ADA plus intensive granulocyte/monocyte adsorptive apheresis (GMA) was initiated, which induced clinical remission. Therefore, combination therapy with ADA plus intensive GMA appears to be an effective therapeutic option for patients with severe CD while under scheduled ADA maintenance therapy.

show abstract

Acute Viral Enteritis and Exacerbations of Inflammatory Bowel Disease

Cited by 52 publications

References 18 publications

Current knowledge and systematic review of viruses associated with Crohn's disease

Current knowledge and systematic review of viruses associated with Crohn's disease

Nutrition and adult inflammatory bowel disease

Combination Therapy with Adalimumab Plus Intensive Granulocyte and Monocyte Adsorptive Apheresis Induced Clinical Remission in a Crohn's Disease Patient with the Loss of Response to Scheduled Adalimumab Maintenance Therapy: A Case Report

Contact Info

Product

Resources

About