Acute viral hepatitis A presented with myopericarditis

Park, Yae Min; Kang, Woong Chol; Shin, Kwen-Chul; Shin, Mi Seung; Chung, Wook‐Jin; Cho, Seong‐Jin; Park, Hyunmi

doi:10.1016/j.ijcard.2011.02.017

Cited by 6 publications

(6 citation statements)

References 9 publications

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“…Therefore, it may be worthwhile to monitor patients for cardiac abnormalities despite signs of improving transaminases. In the case reported by Park et al [ 6 ] ECG changes preceded troponin elevations. They suggest obtaining echocardiography in the setting of ECG changes even if troponin is not elevated.…”

Section: Discussionmentioning

confidence: 94%

“…This differs from our case in that troponin elevation coincided with our patient's symptoms and nonspecific ECG changes, indicating a variable timeline to injury. The patient reported by Park et al [ 6 ] had milder elevations in transaminases, with milder troponin elevation and a decreased ejection fraction to only 52% [ 6 ]. In the case reported by Jagtap et al [ 7 ] their patient had higher elevations in transaminases like our patient and similar elevations in bilirubin and INR, with a larger depression in ejection fraction to 35%.…”

Section: Discussionmentioning

confidence: 99%

“…Extrahepatic manifestations may include urticarial and maculopapular rash, acute kidney injury, autoimmune hemolytic anemia, aplastic anemia, acute pancreatitis, mononeuritis, reactive arthritis, Guillain–Barre syndrome and pleural or pericardial effusion, glomerulonephritis, polyarteritis nodosa, cryoglobulinemia, and thrombocytopenia [ 4 , 5 ]. Myocarditis is a very rare extrahepatic complication with only three reported cases [ 6 – 8 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Very Rare Complication of Hepatitis A Infection: Acute Myocarditis—A Case Report with Literature Review

Allen

Edhi

Hafeez

et al. 2018

Case Reports in Medicine

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Hepatitis A is a common viral infection with a benign course but in rare cases can progress to acute liver failure. It usually presents with abdominal pain, nausea, vomiting, diarrhea, jaundice, anorexia, or asymptomatically, but it can also present atypically with relapsing hepatitis and prolonged cholestasis. In addition, extrahepatic manifestations have been reported, including urticarial and maculopapular rash, acute kidney injury, autoimmune hemolytic anemia, aplastic anemia, acute pancreatitis, mononeuritis, reactive arthritis, glomerulonephritis, cryoglobulinemia, Guillain–Barre syndrome, and pleural or pericardial effusion. A rare manifestation of hepatitis A is acute myocarditis. We report a case of a young woman who presented with “flu-like symptoms” and was found to have severe elevation of liver enzymes due to acute hepatitis A infection. On her 3rd day of admission, the patient developed chest pain and nonspecific electrocardiographic changes. Her troponins rose to 16.4 ng/mL, and a transthoracic echocardiogram revealed global hypokinesis and a depressed ejection fraction at 30%. A CT angiography showed no evidence of significant coronary artery disease. The patient was managed supportively, and symptoms and laboratory findings slowly improved over the next 7 days. Her chest pain resolved and a follow-up echocardiogram showed improved ejection fraction to 45%.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Very Rare Complication of Hepatitis A Infection: Acute Myocarditis—A Case Report with Literature Review

Allen

Edhi

Hafeez

et al. 2018

Case Reports in Medicine

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“…The mechanisms proposed are prerenal factors, direct nephrotoxicity of hyperbilirubinemia, glomerulonephritis, interstitial nephritis, acute tubular necrosis and AKI resulting from massive intravascular haemolysis. ARDS and myocarditis 11,12 were relatively rare nonetheless fatal features. Other less common manifestations were pancreatitis, HUS, macular oedema and cholecystitis.…”

Section: Discussionmentioning

confidence: 99%

Extra Hepatic Manifestations of Viral Hepatitis A

Remya¹,

Thulaseedharan²

2019

jebmh

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BACKGROUND The manifestations of Viral Hepatitis A are not confined to the liver but can involve any part of the body. This is more evident when the disease affects adults when compared to children. There are only a few studies describing the same in viral hepatitis A. We wanted to study the various extra hepatic manifestations of viral hepatitis A. METHODS This is an observational study conducted in Government Medical College, Kozhikode from January 2017 to June 2018. 207 cases of viral hepatitis A in patients older than 13 years admitted over a period of 1.5 years at Government Medical College, Kozhikode, a tertiary care center in South India were included in the study. RESULTS 87 patients of 207 had extra hepatic manifestations during the course of illness. The most common being thrombocytopenia (22.7% of patients) followed by hyponatremia (18.4%), leukocytosis (12.1%), and acute kidney injury (7.7%). Rash, pancreatitis, cholecystitis, myocarditis, macular oedema, HUS and ARDS were also seen. CONCLUSIONS Extra hepatic manifestations are related to more severe disease and hence may be used as a marker of disease severity.

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“…[159][160][161] Other extrahepatic features associated with HAV infection Cardiomyopathy and myocarditis following HAV infection were also reported. [162][163][164] Uveitis, arthritis, and acute pancreatitis may also be associated with HAV infection. [165][166][167][168] Thus, attention should be paid to the extrahepatic manifestation associated with hepatitis A.…”

Section: Neuromuscular Complicationsmentioning

confidence: 99%

Recent advances in hepatitis A virus research and clinical practice guidelines for hepatitis A virus infection in Japan

Kanda,

Sasaki‐Tanaka,

Ishii

et al. 2023

Hepatology Research

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In 2018, there was a hepatitis A outbreak in Japan, and hepatitis A virus (HAV) infection is considered a sexually transmitted disease. In general, patients with hepatitis A should be given attention, and this disease should be prevented more than ever. The Japan Agency for Medical Research and Development (AMED) Hepatitis A and E viruses (HAV and HEV) Study Group has worked on the project to create “Recent Advances in Hepatitis A Virus (HAV) Research and Clinical Practice Guidelines for HAV Infection in Japan”. The group consists of expert hepatologists and virologists who gathered at virtual meeting on August 5, 2023. Data about the pathogenesis, infection routes, diagnosis, complications, several factors for the severities, vaccination, and current and future treatments for hepatitis A were discussed and debated for a draft version. The participants assessed the quality of cited studies. The finalized recommendations are presented in this review. The recent advances in HAV research and clinical practice for HAV infection in Japan, have been reviewed by the AMED HAV and HEV Study Group.

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Acute viral hepatitis A presented with myopericarditis

Cited by 6 publications

References 9 publications

A Very Rare Complication of Hepatitis A Infection: Acute Myocarditis—A Case Report with Literature Review

A Very Rare Complication of Hepatitis A Infection: Acute Myocarditis—A Case Report with Literature Review

Extra Hepatic Manifestations of Viral Hepatitis A

Recent advances in hepatitis A virus research and clinical practice guidelines for hepatitis A virus infection in Japan

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