Acute withdrawal but not long-term withdrawal from methamphetamine affects sexual behavior in female rats

Thibodeau‐Nielsen, Rachel B.; Ornelas, Laura C.; Romero, J. M. Calvo; Memos, Nicoletta; Scheible, Matthew; Avila, Alfred; Schumacher, Abby; Navarro, April; Zimmermann, Karen; Cuenod, Bethany A.; Frohardt, Russell J.; Guarraci, Fay A.

doi:10.1016/j.pbb.2012.12.011

Cited by 6 publications

(1 citation statement)

References 27 publications

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“…Methamphetamine did not modify sexual behavior when tested after 6 or 21 days of abstinence. Results indicate that MA failed to induce a cross-sensitization with sexual behavior ( Thibodeau et al, 2013 ).…”

Section: Behavioral Pharmacology Of Paced Matingmentioning

confidence: 98%

Being friendly: paced mating for the study of physiological, behavioral, and neuroplastic changes induced by sexual behavior in females

Ventura-Aquino,

Paredes

2023

Front. Behav. Neurosci.

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Paced mating in rats is an experimental condition that allows the evaluation of sexual behavior in a way that closely resembles what occurs in seminatural and natural conditions enabling the female to control the rate of the sexual interaction. In conventional non-paced mating tests, females cannot escape from male approaches, which may lead to an unrewarding overstimulation. Paced mating is an alternative laboratory procedure that improves animal welfare and has a higher ethological relevance. The use of this procedure contributed to the identification of physiological and behavioral factors that favor reproduction. Paced mating includes motivational and behavioral components differentiating quantitative and qualitative characteristics that are critical for the induction of the rewarding properties of mating. These positive consequences ensure that the behavior will be repeated, favoring the species’ survival. Sexual reward is an immediate consequence of paced mating, mediated mainly by the endogenous opioid system. Paced mating also induces long-lasting neuroplastic changes, including gene expression, synthesis of proteins, and neurogenesis in sex-relevant brain areas. The interest in paced mating is growing since the complexity of its elements and consequences at different levels in a laboratory setting resembles what occurs in natural conditions. In this review, we analyze the classic studies and recent publications demonstrating the advantages of using paced mating to evaluate different aspects of sexual behavior in females.

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Section: Behavioral Pharmacology Of Paced Matingmentioning

confidence: 98%

Being friendly: paced mating for the study of physiological, behavioral, and neuroplastic changes induced by sexual behavior in females

Ventura-Aquino,

Paredes

2023

Front. Behav. Neurosci.

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Paced Mating Behaviour Is Influenced by Duration of Female Post-Ejaculatory Interval

Corlett

Frankl

Akindona

et al. 2022

The Journal of Sexual Medicine

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Background Laboratory paradigms that enable the female rat to control the frequency and temporal distribution of sexual stimulation are well-suited to gaining knowledge about female sexual function; however, the variety of procedures used influence the specific behaviors exhibited by female rats and bring uncertainty into the conclusions that can be drawn. Aim In this study, we evaluated the effects of test parameters on the display of paced mating behavior in female rats to develop better preclinical models for exploring female sexual health. Methods Sexually experienced, estradiol- and progesterone-primed female rats were tested under paced mating conditions to determine whether sexual behavior differed as a function of number of male partners (1 or 3; Experiment 1), the time span between receipt of an ejaculation and the next intromission (ie, the post-ejaculatory interval or PEI; Experiment 2), or the duration of ejaculations (Experiment 3). Outcomes Contact-return latency, exit latency, and withdrawal duration after mounts, intromissions, and ejaculations. Results The shorter withdrawal latency after intromission and longer return latency after ejaculation observed in 30-minute paced mating tests is best attributed to the female’s PEI. The duration of the PEI is a specific factor that affects the display of paced mating behavior. Clinical Translation Understanding of neurobiological mechanisms and sensory factors influencing sexual behavior learned from these models can be applied to studies of human female sexual health. Strengths & Limitations Sexual motivation is indicated by analogous behaviors and supported by evolutionarily conserved systems in women and rats, meaning that animal models can be used to identify neurobiological mechanisms subserving these behaviors. Nonetheless, data related specifically to physiological effects of different mating paradigms are needed in future research. Conclusion Procedures that mimic naturalistic settings, and thus enable female sexual motivation to drive behavior, are apt for studies aimed at understanding mechanisms supporting female sexual function whereas artificially lengthening the interval between an ejaculation and subsequent intromission may provide a model to study female sexual dysfunction.

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“Sexy stimulants”: The interaction between psychomotor stimulants and sexual behavior in the female brain

Guarraci¹,

Bolton²

2014

Pharmacology Biochemistry and Behavior

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Acute withdrawal but not long-term withdrawal from methamphetamine affects sexual behavior in female rats

Cited by 6 publications

References 27 publications

Being friendly: paced mating for the study of physiological, behavioral, and neuroplastic changes induced by sexual behavior in females

Being friendly: paced mating for the study of physiological, behavioral, and neuroplastic changes induced by sexual behavior in females

Paced Mating Behaviour Is Influenced by Duration of Female Post-Ejaculatory Interval

“Sexy stimulants”: The interaction between psychomotor stimulants and sexual behavior in the female brain

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