2005
DOI: 10.1016/j.cps.2004.12.001
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Acute Wounds

Abstract: The most important factors in the management of acute wounds are the history and physical examination. The goals of wound care are fivefold: avoid further tissue damage, achieve wound closure as rapidly as possible, restore function to the injured tissue, facilitate the patient's expedient return to normal daily activities, and restore the patient's quality of life. The treating physician must have a good understanding of the wound healing mechanism. One must rule out all associated occult injuries that may be… Show more

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Cited by 86 publications
(48 citation statements)
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“…Differences in tissue structures over the 12-day wound healing process were clearly identified and correlated well with the corresponding histology and published expectations. 2,3,12,[49][50][51] One of the first noticeable changes in preparation for epidermal migration ͓day 4, Fig. 6͑b͔͒ is the thickening of the epidermis immediately adjacent to the wound probably due to the mitotic activity of nearby basal cells.…”
Section: Discussionmentioning
confidence: 99%
“…Differences in tissue structures over the 12-day wound healing process were clearly identified and correlated well with the corresponding histology and published expectations. 2,3,12,[49][50][51] One of the first noticeable changes in preparation for epidermal migration ͓day 4, Fig. 6͑b͔͒ is the thickening of the epidermis immediately adjacent to the wound probably due to the mitotic activity of nearby basal cells.…”
Section: Discussionmentioning
confidence: 99%
“…Fibroblasts are attracted to the wound area by a number of factors, such as PDGF and TGF- (Goldman 2004), and dominate the wound cell population in the first week. Within the wound area, fibroblasts proliferate and produce multiple structural molecules, including fibrin, fibronectin, glycosaminoglycans (GAGs), later followed by collagen (Witte and Barbul 1997;Robson, Steed et al 2001;Ramasastry 2005). Together, these components construct the fibrin/fibronectin based provisional matrix (Clark, Lanigan et al 1982), which contributes to the formation of granulation tissue.…”
Section: Fibroblast Migrationmentioning
confidence: 99%
“…As feridas de espessura total, ou seja, que atingem até a hipoderme, dependem da migração e proliferação dos queratinócitos das bordas das lesões, geralmente cursam com cicatrização mais lenta e resultam na formação de cicatriz (Ramasastry, 2005).…”
Section: Cicatrização Da Peleunclassified
“…Células da ferida retornam a um fenótipo estável e o tecido de granulação, que era exuberante durante as fases iniciais da cicatrização, começa a desaparecer (Ramasastry, 2005 (Asawanonda e Taylor, 1999).…”
Section: Cicatrização Da Peleunclassified