“…Fibroblasts are attracted to the wound area by a number of factors, such as PDGF and TGF- (Goldman 2004), and dominate the wound cell population in the first week. Within the wound area, fibroblasts proliferate and produce multiple structural molecules, including fibrin, fibronectin, glycosaminoglycans (GAGs), later followed by collagen (Witte and Barbul 1997;Robson, Steed et al 2001;Ramasastry 2005). Together, these components construct the fibrin/fibronectin based provisional matrix (Clark, Lanigan et al 1982), which contributes to the formation of granulation tissue.…”