Acute Zonal Occult Outer Retinopathy (AZOOR)

A Case of an Acute Zonal Occult Outer Retinopathy Variant Characterized With an Insidious Peripheral Onset and Centripetal Progression

“…During the initial stages, patients usually exhibit minimal noticeable fundus changes, such as subtle pigmentary alterations in the peripapillary zone, alongside visual symptoms, such as photopsia, decreased contrast sensitivity, and photophobia. As the disease progresses, the lesion becomes more evident, with a welldefined and sequentially demarcated atrophic zone affecting the outer retina, retinal pigment epithelium (RPE), and choroid [1][2][3][4].…”

“…AZOOR lesions commonly originate in the peripapillary zone and tend to progress centrifugally toward the peripheral fundus [1][2][3][4]. This case report aims to delineate the clinical and multimodal imaging characteristics of a 63-year-old female with a symmetric, peripheral-onset AZOOR variant demonstrating a very slow centrifugal progression.…”

“…The term acute zonal occult outer retinopathy (AZOOR) describes the rapid loss of one or multiple large zones of the outer retinal layers, often presenting with a distinctive sectoral distribution [ 1 ]. During the initial stages, patients usually exhibit minimal noticeable fundus changes, such as subtle pigmentary alterations in the peripapillary zone, alongside visual symptoms, such as photopsia, decreased contrast sensitivity, and photophobia.…”