Acyclovir treatment in stromal herpetic keratitis

Ja, Oosterhuis; R, van Ganswijk; Versteeg, J.

doi:10.1007/bf00154713

Cited by 3 publications

(1 citation statement)

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“…This is longer than previously reported in a study where all patients with deep stromal keratitis treated with acylovir ointment and 2 5% prednisolone showed resolution of symptoms in one week. 9 However, in the latter study patients were entered if they showed signs of stromal infiltration and were excluded if they had oedema of the disciform type. In addition the concentration of prednisolone used was 50 times greater than that used in the present study.…”

Section: Discussionmentioning

confidence: 99%

A comparison of local and systemic acyclovir in the management of herpetic disciform keratitis.

Porter¹,

Patterson²,

Kho³

1990

British Journal of Ophthalmology

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Forty-three patients with active herpetic disciform keratitis were entered into an open study to compare the efficacy of oral acyclovir (400 mg) with acyclovir ophthalmic ointment (3%) to inhibit viral replication during treatment with 0-05% prednisolone eye drops. All patients, regardless of the mode of therapy, were treated five times a day until they were healed. The mean time to heal in the oral group was 25 9 days and in the topical group was 25 3 days. Resolution of lacrimation was significantly faster in the oral group (12.1 days versus 27-6 days). The patients on tablets also showed a greater improvement in visual acuity. No statistically significant differences were found between the two groups in the incidence of recurrences over a three-year post-treatment period. It is concluded that oral acyclovir treatment is an effective alternative to ophthalmic ointment in the management of herpetic disciform keratitis.

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Section: Discussionmentioning

confidence: 99%