Acyl-coenzyme A:cholesterol-acyltransferase (ACAT) inhibitors modulate monocyte adhesion to aortic endothelial cells

Acyl-CoA:Cholesterol Acyltransferase Inhibitor Avasimibe Reduces Atherosclerosis in Addition to Its Cholesterol-Lowering Effect in ApoE*3-Leiden Mice

“…5 This is in agreement with in vitro studies that have shown that ACAT inhibitors can decrease monocyte adhesion to endothelial cells. 35 It suggests that treatment with avasimibe reduces endothelial activation. Whether avasimibe indeed decreases the expression of adhesion and/or chemoattractant molecules in the endothelium remains to be investigated.…”

Inhibition of E-Selectin-, ICAM-1-, and VCAM-1-Mediated Cell Adhesion by Benzo[b]thiophene-, Benzofuran-, Indole-, and Naphthalene-2-carboxamides: Identification of PD 144795 as an Antiinflammatory Agent

“…Pretreatment of human aortic endothelial cells (HAECs) with TNF-a overnight resulted in the upregulation of VCAM-1 and ICAM-1 leading to an increase in the number of adherent U937 monocytic cells. 28 This monocyte adhesion was reduced when the HAECs were preincubated with both TNFand PD 144795 (IC50 = 8.8 µ ).…”

“…Anal. (ChHi0C1NO2S) C, , N. 3-Chloro-5-methoxy-2V-(l-methylethyl)benzo [6]thiophene-2-carboxamide (28). To a 33.3 mL aliquot removed from the above reaction solution (preparation of 27) was added isopropylamine (640 µ , 7.40 mmol).…”

“…Protocol was essentially run as previously reported. 28 Vascular Cell Adhesion Molecule-1 and Intercellular Cell Adhesion Molecule-1 HAEC Surface Expression Assay (VCAMA and ICAMA). Cell Culture and Cytokine Stimulation.…”