Acylated ghrelin levels were associated with depressive status, physical quality of life, endoscopic findings based on Kyoto classification in Japan

Agawa, Shuhei; Futagami, Seiji; Yanagawa, Hiroshi; Ikeda, Go; Noda, Hiroto; Kirita, Kumiko; Higuchi, Kazutoshi; Murakami, Makoto; Kodaka, Yasuhiro; Ueki, Nobue; Akamizu, Takashi; Iwakiri, Katsuhiko

doi:10.3164/jcbn.18-111

Cited by 13 publications

(9 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IM within the antrum was scored as 1, and IM extending into the corpus was scored as 2. ( 27 ) The presence of folds enlarged over 5 mm or more was scored as 1. ( 28 ) Nodularity is characterized by the appearance of multiple whitish elevated lesions mainly in the pyloric gland mucosa.…”

Section: Methodsmentioning

confidence: 99%

A single nucleotide polymorphism in <i>Prostate Stem Cell Antigen</i> is associated with endoscopic grading in Kyoto classification of gastritis

Toyoshima¹,

Nishizawa

Sekiba

et al. 2021

J. Clin. Biochem. Nutr.

View full text Add to dashboard Cite

The risk allele of a single nucleotide polymorphism (SNP) rs2294008 in the Prostate stem cell antigen ( PSCA ) gene is strongly associated with gastric cancer. Although the Kyoto classification score is believed to be an indicator of gastric cancer risk, it lacks supporting genetic evidence. We investigated the effect of this risk allele of PSCA SNP on the Kyoto score. Participants without a history of gastric cancer or Helicobacter pylori ( H. pylori ) eradication underwent esophagogastroduodenoscopy, H. pylori evaluation, and SNP genotyping. The Kyoto score is the sum of scores obtained from endoscopy-based atrophy, intestinal metaplasia, enlarged folds, nodularity, and diffuse redness. The Kyoto score is novel in the light of scoring for gastritis. A total of 323 patients were enrolled (number of individuals with genotype CC: 52; CT: 140; TT: 131, average age: 50.1 years, male: 50.8%). The patient baseline characteristics including age, sex, body mass index, smoking, drinking, family history of gastric cancer, and H. pylori status had no association with PSCA SNP. The Kyoto score was higher in T (CT or TT genotype; risk allele) carriers than in CC carriers. Atrophy, enlarged folds, and diffuse redness scores were higher in T allele carriers (risk allele) than in CC genotype individuals. In multivariate analysis, the Kyoto score was independently associated with PSCA SNP (OR: 1.30, p = 0.012). Thus, the Kyoto score was associated with a genetic predisposition.

show abstract

Section: Methodsmentioning

confidence: 99%

A single nucleotide polymorphism in <i>Prostate Stem Cell Antigen</i> is associated with endoscopic grading in Kyoto classification of gastritis

Toyoshima¹,

Nishizawa

Sekiba

et al. 2021

J. Clin. Biochem. Nutr.

View full text Add to dashboard Cite

show abstract

“…A genome-wide DNA methylation profile analysis conducted on 34 monozygotic twins with depressive symptoms showed that GHSR DNA methylation was highly associated with depression ( Cordova-Palomera et al, 2018 ). Although the clinical data for the link between ghrelin and MDD are not consistent, most studies have reported that the plasma level of ghrelin is significantly increased in patients with MDD, and is associated with a depressive status ( Wittekind and Kluge, 2015 ; Algul and Ozcelik, 2018 ; Agawa et al, 2019 ). Animal studies have consistently found that the plasma levels of ghrelin are elevated in adult mice following chronic stress, including chronic social defeat stress (CSDS) and chronic mild stress (CMS) ( Lutter et al, 2008 ; Chuang et al, 2011 ; Harmatz et al, 2017 ; Huang et al, 2017 ; Han et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

The Ghrelin/Growth Hormone Secretagogue Receptor System Is Involved in the Rapid and Sustained Antidepressant-Like Effect of Paeoniflorin

Zhang

Zhu

Qin³

et al. 2021

Front. Neurosci.

View full text Add to dashboard Cite

Major depressive disorder (MDD) is a debilitating mental illness affecting people worldwide. Although significant progress has been made in the development of therapeutic agents to treat this condition, fewer than half of all patients respond to currently available antidepressants, highlighting the urgent need for the development of new classes of antidepressant drugs. Here, we found that paeoniflorin (PF) produced rapid and sustained antidepressant-like effects in multiple mouse models of depression, including the forced swimming test and exposure to chronic mild stress (CMS). Moreover, PF decreased the bodyweight of mice without affecting food intake and glucose homeostasis, and also reduced the plasma levels of total ghrelin and the expression of ghrelin O-acyltransferase in the stomach; however, the plasma levels of ghrelin and the ghrelin/total ghrelin ratio were unaffected. Furthermore, PF significantly increased the expression of growth hormone secretagogue receptor 1 alpha (GHSR1α, encoded by the Ghsr gene) in the intestine, whereas the levels of GHSR1α in the brain were only marginally downregulated following subchronic PF treatment. Finally, the genetic deletion of Ghsr attenuated the antidepressant-like effects of PF in mice exposed to CMS. These results suggested that increased GHSR1α expression in the intestine mediates the antidepressant-like effects of PF. Understanding peripheral ghrelin/GHSR signaling may provide new insights for the screening of antidepressant drugs that produce fast-acting and sustained effects.

show abstract

Section: Introductionmentioning

confidence: 99%

“…The Kyoto classification score was defined as the sum of atrophy score, intestinal metaplasia score, diffuse redness score, nodularity score, and enlarged folds score. (10,11) A high score is believed to reflect an increased risk of stomach cancer. (12) Research related to the Kyoto classification score and gastric cancer risk is still scarce, and the consistency of the Kyoto score with the ABC method remains unclear.…”

mentioning

confidence: 99%

The simplified Kyoto classification score is consistent with the ABC method of classification as a grading system for endoscopic gastritis

Nishizawa

Toyoshima

Kondo

et al. 2021

J. Clin. Biochem. Nutr.

View full text Add to dashboard Cite

The ABC method combined with Helicobacter pylori antibody and serum pepsinogen is a useful predictive method for stomach cancer. Kyoto classification is a new grading system for endoscopic gastritis. However, the consistency of the Kyoto score with the ABC method remains unclear. The Kyoto classification score, which ranges from 0 to 8, is based on the following findings: atrophy, intestinal metaplasia, diffuse redness, nodularity, and enlarged folds. Furthermore, we defined a simplified Kyoto classification score as the sum of scores of just atrophy and intestinal metaplasia. The association between the Kyoto classification score and the ABC method was analyzed using the Kruskal-Wallis and Steel-Dwass tests. A total of 307 subjects were enrolled. Kyoto classification scores were similar in groups B, C, and D, while scores in group A were significantly lower than those of the other groups. The simplified Kyoto classification score showed the same stepwise increase as the classification of the ABC method. In conclusion, unlike the Kyoto classification score, the simplified Kyoto score showed the same significant stepwise increase as the classification of the ABC method.

show abstract

Acylated ghrelin levels were associated with depressive status, physical quality of life, endoscopic findings based on Kyoto classification in Japan

Cited by 13 publications

References 35 publications

A single nucleotide polymorphism in <i>Prostate Stem Cell Antigen</i> is associated with endoscopic grading in Kyoto classification of gastritis

A single nucleotide polymorphism in <i>Prostate Stem Cell Antigen</i> is associated with endoscopic grading in Kyoto classification of gastritis

The Ghrelin/Growth Hormone Secretagogue Receptor System Is Involved in the Rapid and Sustained Antidepressant-Like Effect of Paeoniflorin

The simplified Kyoto classification score is consistent with the ABC method of classification as a grading system for endoscopic gastritis

Contact Info

Product

Resources

About