Acylated saponins and flavonoid glycosides from the fruits of Stewartia koreana

Huh, Jungmoo; Park, Tae Kyu; Chae, Hee‐Sung; Nhoek, Piseth; Kim, Youngmi; An, Chae-Yeong; Lee, Shinae; Kim, Jinwoong; Chin, Young‐Won

doi:10.1016/j.phytochem.2021.112980

Cited by 2 publications

(1 citation statement)

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“…The protein expression was assessed by western blotting according to previous publication. 49 6-Hydroxy-vitexin-2″-O-rhamnoside (7). Hz, H-3′ and 5′), 6.60 (1H, s, H-3), 5.03 (1H, d, J = 9.9 Hz, H-1″), 5.09 (1H, brs, H-1‴), 4.26 (1H, t, J = 9.5 Hz, H-2″), 3.95 (1H, d, J = 12.0 Hz, H-6a″), 3.84 (1H, brs, H-3‴), 3.79 (1H, dd, J = 12.0, 5.9 Hz, H-6b″), 3.62 (2H, overlapped, H-3″ and 4″), 3.45 (1H, m, H-5″), 3.41 (1H, dd, J = 9.7, 3.3 Hz, H-2‴), 3.11 (1H, t, J = 9.5 Hz, H-4‴), 2.46 (1H, qu, J = 7.2 Hz, H-5‴), 0.65 (3H, d, J = 6.1 Hz).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Chemical Constituents from the Roots and Rhizomes of Sophora tonkinensis and Their Effects on Proprotein Convertase Substilisin/Kexin Type 9 Expression

et al. 2022

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This study was conducted to further investigate bioactive molecules from Sophora tonkinensis that can inhibit proprotein convertase substilisin/kexin type 9 (PCSK9) expression. After interpreting NMR spectroscopic data and MS spectral data of all isolates, a new naturally occurring compound, 6-hydroxy-vitexin-2″- O -rhamnoside ( 7 ), was identified along with 30 known compounds. The calculation of the gauge-including atomic orbital (GAIO) and electronic circular dichroism (ECD) proposed the absolute configuration of 17 as (2 S ,3 R )-methyl-2-(4-hydroxybenzyl)tartrate by comparing the calculated ECD with experimental data. All isolates were tested for their inhibitory effects on PCSK9 mRNA expression. Of the tested compounds, (+) - isolariciresinol ( 12 ) inhibited PCSK9 expression via downregulation of HNF1α and SREBPs.

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Section: ■ Results and Discussionmentioning

confidence: 99%