Acylphloroglucinol and tocotrienol derivatives from the fruits of Garcinia multiflora

Liu, Hui; Gan, Fei; Jin, Shuai; Li, Jun; Chen, Yu; Yang, Guangzhong

doi:10.1039/c7ra04208f

Cited by 11 publications

(8 citation statements)

References 22 publications

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“…Moreover, garcinol has also been reported by chemists from G. multiflora, with an yield of 0.5 gm per 5.2 kg dried fruits [24,25]. Other Garcinia species, including G. morella, G. yunnanensis, G. xanthochymus, G.travancorica, and G. buchananii, have also been considered a promising source of garcinol [26][27][28][29][30].…”

Section: Chemistry Of Garcinolmentioning

confidence: 98%

“…Other Garcinia species, including G. morella, G. yunnanensis, G. xanthochymus, G.travancorica, and G. buchananii, have also been considered a promising source of garcinol [26][27][28][29][30]. Moreover, garcinol has also been reported by chemists from G. multiflora, with an yield of 0.5 gm per 5.2 kg dried fruits [24,25]. Other Garcinia species, including G. morella, G. yunnanensis, G.…”

Section: Chemistry Of Garcinolmentioning

confidence: 99%

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Garcinol Exhibits Anti-Neoplastic Effects by Targeting Diverse Oncogenic Factors in Tumor Cells

et al. 2020

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Garcinol, a polyisoprenylated benzophenone, is the medicinal component obtained from fruits and leaves of Garcinia indica (G. indica) and has traditionally been extensively used for its antioxidant and anti-inflammatory properties. In addition, it has been also been experimentally illustrated to elicit anti-cancer properties. Several in vitro and in vivo studies have illustrated the potential therapeutic efficiency of garcinol in management of different malignancies. It mainly acts as an inhibitor of cellular processes via regulation of transcription factors NF-κB and JAK/STAT3 in tumor cells and have been demonstrated to effectively inhibit growth of malignant cell population. Numerous studies have highlighted the anti-neoplastic potential of garcinol in different oncological transformations including colon cancer, breast cancer, prostate cancer, head and neck cancer, hepatocellular carcinoma, etc. However, use of garcinol is still in its pre-clinical stage and this is mainly attributed to the limitations of conclusive evaluation of pharmacological parameters. This necessitates evaluation of garcinol pharmacokinetics to precisely identify an appropriate dose and route of administration, tolerability, and potency under physiological conditions along with characterization of a therapeutic index. Hence, the research is presently ongoing in the dimension of exploring the precise metabolic mechanism of garcinol. Despite various lacunae, garcinol has presented with promising anti-cancer effects. Hence, this review is motivated by the constantly emerging and promising positive anti-cancerous effects of garcinol. This review is the first effort to summarize the mechanism of action of garcinol in modulation of anti-cancer effect via regulation of different cellular processes.

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Section: Chemistry Of Garcinolmentioning

confidence: 98%

Section: Chemistry Of Garcinolmentioning

confidence: 99%

Garcinol Exhibits Anti-Neoplastic Effects by Targeting Diverse Oncogenic Factors in Tumor Cells

et al. 2020

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“…Another suitable large scale isolation method initially removed hydroxycitric acid from Garcinia indica fruits by washing with water, followed by methanol extraction of the fruits, adsorption of the concentrated methanol extract on Celite and extraction of the methanol extract loaded Celite with hexane followed by column chromatography of the hexane extract . Recently, garcinol and isogarcinol were isolated from fruits of Garcinia multiflora , a medicinal plant of South China known for its antioxidant activity . The authors obtained 500 mg garcinol and 101 mg isogarcinol from 5.2 kg dried G. multiflora fruits (powdered dried G. multiflora fruits were extracted with 95 % ethanol and the ethanol extract was extracted with petroleum ether followed by column chromatography on silica gel and recrystallization to obtain garcinol) .…”

Section: An Update On the Isolation Analysis And Synthesis Of Garcimentioning

confidence: 99%

“…Recently, garcinol and isogarcinol were isolated from fruits of Garcinia multiflora , a medicinal plant of South China known for its antioxidant activity . The authors obtained 500 mg garcinol and 101 mg isogarcinol from 5.2 kg dried G. multiflora fruits (powdered dried G. multiflora fruits were extracted with 95 % ethanol and the ethanol extract was extracted with petroleum ether followed by column chromatography on silica gel and recrystallization to obtain garcinol) . Garcinol was also detected in and isolated from plants of the Garcinia species G. morella , G. yunnanensis , G. xanthochymus and G. travancorica .…”

Section: An Update On the Isolation Analysis And Synthesis Of Garcimentioning

confidence: 99%

“…[10,12] The authors obtained 500 mg garcinol and 101 mg isogarcinol from 5.2 kg dried G. multiflora fruits (powdered dried G. multiflora fruits were extracted with 95 % ethanol and the ethanol extract was extracted with petroleum ether followed by column chromatography on silica gel and recrystallization to obtain garcinol). [12] Garcinol was also detected in and isolated from plants of the Garcinia species G. morella, G. yunnanensis, G. xanthochymus and G. travancorica. [13][14][15][16] In addition, garcinol and isogarcinol were recently found in the stem bark of the Garcinia species G. buchananii.…”

Section: An Update On the Isolation Analysis And Synthesis Of Garcimentioning

confidence: 99%

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Chemical and Biological Aspects of Garcinol and Isogarcinol: Recent Developments

Schobert

Biersack

2019

Chemistry & Biodiversity

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The natural polyisoprenylated benzophenone derivatives garcinol and isogarcinol are secondary plant metabolites isolated from various Garcinia species including Garcinia indica. This review takes stock of the recent chemical and biological research into these interesting natural compounds over the last five years. New biological sources and chemical syntheses are discussed followed by new insights into the activity of garcinol and isogarcinol against cancer, pathogenic bacteria, parasite infections and various inflammatory diseases.

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Garcinol in gastrointestinal cancer prevention: recent advances and future prospects

Patwa,

Chauhan,

Chauhan

et al. 2024

J Cancer Res Clin Oncol

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Gastrointestinal cancers continue to pose a significant global health challenge, with millions of new cases diagnosed each year. Despite advancements in treatment, the prognosis for many patients remains poor. This article explores the potential of garcinol, a polyisoprenylated benzophenone found in various Garcinia species, as a therapeutic agent against gastrointestinal malignancies. The objective is to review recent research on garcinol’s anticancer properties, its mechanisms of action, and safety aspects. Garcinol exhibits anticancer effects in esophageal, gastric, colorectal, pancreatic, and liver cancers by inhibiting metastasis, inducing apoptosis, and targeting key molecular pathways in cancer progression. Nanotechnology is explored as a means to enhance garcinol delivery and efficacy. Safety assessments suggest a promising toxicity profile. Garcinol shows significant potential as a natural therapeutic agent for gastrointestinal cancers, and future research is needed on optimizing its delivery, exploring synergistic combinations, and conducting clinical trials to validate its efficacy and safety for clinical applications.

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Acylphloroglucinol and tocotrienol derivatives from the fruits of Garcinia multiflora

Abstract: A new regioisomeric pair of garcimultine A (1) and B (2), and one new tocotrienol derivative garcimultine C (8) from the fruits of Garcinia multiflora showed moderate cytotoxicity on four human tumor cell lines.

Cited by 11 publications

References 22 publications

Garcinol Exhibits Anti-Neoplastic Effects by Targeting Diverse Oncogenic Factors in Tumor Cells

Garcinol Exhibits Anti-Neoplastic Effects by Targeting Diverse Oncogenic Factors in Tumor Cells

Chemical and Biological Aspects of Garcinol and Isogarcinol: Recent Developments

Garcinol in gastrointestinal cancer prevention: recent advances and future prospects

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