Acylphloroglucinol trimers from Callistemon salignus seeds: Isolation, configurational assignment, hAChE inhibitory effects, and molecular docking studies

Yu, Mu-Yuan; Liu, Si-Na; Liu, Hui; Meng, Qinghong; Qin, Xu‐Jie; Liu, Haiyang

doi:10.1016/j.bioorg.2021.105404

Cited by 12 publications

(1 citation statement)

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“…The acetylcholinesterase inhibitory activity of compounds 1 – 34 was assessed with a modified spectrophotometric method, , using chlorpyriphos and huperzine A as the positive controls (see details in the Supporting Information).…”

Section: Methodsmentioning

confidence: 99%

Ormosianines A–P, Structurally Diverse Quinolizidine Alkaloids with AChE Inhibitory Effects from Ormosia yunnanensis

Jin,

Qin,

Sun

et al. 2023

J. Nat. Prod.

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Sixteen new quinolizidine alkaloids (QAs), named ormosianines A–P (1–16), and 18 known congeners (17–34) were isolated from the stems and leaves of Ormosia yunnanensis. The structures were elucidated based on spectroscopic analyses and electron circular dichroism (ECD) calculations. Structurally, ormosianines A (1) and B (2) are the first examples of cytisine and Ormosia-type alkaloids with the cleavage of the piperidine ring. Results of the acetylcholinesterase (AChE) inhibitory assay revealed that the pentacycline Ormosia-type QAs, including 1, 16, 24, and 27–29, are good AChE inhibitors. Ormosianine A (1) exhibited more potent AChE inhibitory activity with an IC50 value of 1.55 μM. Molecular docking revealed that 1 might bind to the protein 1DX4, forming two hydrogen bonds with residues SER-238 and HIS-480.

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Section: Methodsmentioning

confidence: 99%