“…The family of ADAM proteins has over 35 members which function as cell adhesion molecules and/or proteases (Black & White, 1998; Rocks et al, 2008; Seals & Courtneidge, 2003; J. M. White, 2003). ADAMs are involved in cell–cell and cell–extracellular interactions associated with angiogenesis, platelet aggregation, cell migration, muscle development, tumor growth, immunity, and other cellular processes (Bax et al, 2004; Dreymueller, Theodorou, Donners, & Ludwig, 2017; Edwards et al, 2008; Lambrecht, Vanderkerken, & Hammad, 2018; Rocks et al, 2008; Seals & Courtneidge, 2003; Zadka et al, 2018). ADAMs are transmembrane glycoproteins and occur as functional heterodimers (α and β subunits) in many tissues and across different species (Bronson, Fusi, Calzi, Doldi, & Ferrari, 1999; Edwards et al, 2008).…”