2018
DOI: 10.4149/neo_2018_171220n832
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ADAM protein family – its role in tumorigenesis, mechanisms of chemoresistance and potential as diagnostic and prognostic factors

Abstract: ADAMs are a family of transmembrane proteins described for the first time in the 1990's. ADAMs is an abbreviation of "A Disintegrin and Metallo-proteinases". Their earliest known role was involvement in gamete fusion, and their adhesion properties in intercellular interactions also suggested involvement in tumor biology. Further research emphasized the importance of ADAM proteins in the regulation of neoplastic processes due to their influence on adhesion, cell migration, proteolysis and cell signaling. Variab… Show more

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Cited by 13 publications
(16 citation statements)
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References 164 publications
(220 reference statements)
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“…The family of ADAM proteins has over 35 members which function as cell adhesion molecules and/or proteases (Black & White, 1998; Rocks et al, 2008; Seals & Courtneidge, 2003; J. M. White, 2003). ADAMs are involved in cell–cell and cell–extracellular interactions associated with angiogenesis, platelet aggregation, cell migration, muscle development, tumor growth, immunity, and other cellular processes (Bax et al, 2004; Dreymueller, Theodorou, Donners, & Ludwig, 2017; Edwards et al, 2008; Lambrecht, Vanderkerken, & Hammad, 2018; Rocks et al, 2008; Seals & Courtneidge, 2003; Zadka et al, 2018). ADAMs are transmembrane glycoproteins and occur as functional heterodimers (α and β subunits) in many tissues and across different species (Bronson, Fusi, Calzi, Doldi, & Ferrari, 1999; Edwards et al, 2008).…”
Section: Families Of Adhesion Moleculesmentioning
confidence: 99%
See 1 more Smart Citation
“…The family of ADAM proteins has over 35 members which function as cell adhesion molecules and/or proteases (Black & White, 1998; Rocks et al, 2008; Seals & Courtneidge, 2003; J. M. White, 2003). ADAMs are involved in cell–cell and cell–extracellular interactions associated with angiogenesis, platelet aggregation, cell migration, muscle development, tumor growth, immunity, and other cellular processes (Bax et al, 2004; Dreymueller, Theodorou, Donners, & Ludwig, 2017; Edwards et al, 2008; Lambrecht, Vanderkerken, & Hammad, 2018; Rocks et al, 2008; Seals & Courtneidge, 2003; Zadka et al, 2018). ADAMs are transmembrane glycoproteins and occur as functional heterodimers (α and β subunits) in many tissues and across different species (Bronson, Fusi, Calzi, Doldi, & Ferrari, 1999; Edwards et al, 2008).…”
Section: Families Of Adhesion Moleculesmentioning
confidence: 99%
“…This can include uncontrolled cellular growth and metastasis (Adorno‐Cruz & Liu, 2019). Indeed, much of what is known about adhesion molecules and cellular function has come from studies in cancer biology (Buchanan et al, 2017; Edwards, Handsley, & Pennington, 2008; Najy, Day, & Day, 2008; Shiomi, Lemaitre, D'Armiento, & Okada, 2010; Sousa, Pereira, & Paredes, 2019; Zadka, Kulus, & Piatek, 2018).…”
Section: Introductionmentioning
confidence: 99%
“…The mammalian ADAM protein family consists of 40 members, according to current research, and contains a metalloproteinase and disintegrin domain that combines proteolytic and adhesive functions [6,7]. This family is involved in various physiological and pathological processes, including cellular development, modulation of inflammatory reactions, and formation and progression of cancer via the release of membrane-bound proteins, such as adhesion molecules, cytokines, chemokines, and growth factors [8][9][10].…”
Section: Introductionmentioning
confidence: 99%
“…Although ADAMs contribute to diverse physiological functions, they are also associated with pathological conditions such as cancer. Indeed, implication of ADAMs in cancer has been extensively described in the literature since they can modulate various processes including proliferation, apoptosis, migration and invasion of tumor cells as well as angiogenesis [3][4][5]. However, accumulating evidence demonstrates that metalloproteinases such as ADAMs can also exert protective effects against tumor progression [6].…”
Section: Introductionmentioning
confidence: 99%