Adamantane derivatives: Pharmacological and toxicological properties (review)

Спасов, А. А.; Khamidova, T. V.; Бугаева, Л. И.; Morozov, Igor

doi:10.1007/bf02524549

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Viral Adsorption and Penetration1

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Cited by 106 publications

(65 citation statements)

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“…Molecule of adamantane consists of three cyclohexane rings [19]. The adamantane is not used currently, but the possibility of introducing in position 1 or 3 of different substituents making it promising for antiviral therapy [20].…”

Section: Viral Adsorption and Penetrationmentioning

confidence: 99%

Levels of Antiviral Therapy

Ap¹,

Turmagambetova²,

Berezin³

2016

JHVRV

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Section: Viral Adsorption and Penetrationmentioning

confidence: 99%

Levels of Antiviral Therapy

Ap¹,

Turmagambetova²,

Berezin³

2016

JHVRV

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“…The most often used one is gludantan, the adamantamine conjugate of glucuronic acid, which is used as an antiviral agent as well as a drug in the treatment of Parkinson disease and depression. 11 It is also known that introducing an adamantyl moiety into substances with known biological activity improves their pharmacological properties mostly due to its pronounced lipophilic character. 12,13 Furthermore, the role of adamantane conjugates with mannose in the process of preventing microbial adhesion to host cells was recently discussed as well.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Evaluation of New Mannose Derived Immunomodulating Adamantyltripeptides

et al. 2011

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Abstract. A novel class of mannosylated adamantyltripeptides, general formula of which is α-Man-OCH 2 CH(CH 3 )CO-AdGly-L-Ala-D-isoGln, were prepared, characterized, and their possible immunomodulatory properties investigated in some preliminary tests in vivo. All newly synthesized glycopeptides comprise in their structure the adamantylglycyl moiety linked to the dipeptide L-Ala-D-isoGln, as well as mannose. Adjuvant activity of mannosylated adamant-2-yl tripeptides was tested in the mouse model using ovalbumin as an antigen and in comparison to the peptidoglycan monomer (PGM, β-D-GlcNAc-(1→4)-D-MurNAc-L-Ala-D-isoGln-mesoDAP(εNH 2 )-D-Ala-D-Ala).

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“…Compounds containing adamantane are used in clinical practice to treat viral and psychological diseases [1]. They also exhibit antitumor and antimicrobial activity [2 -5].…”

mentioning

confidence: 99%