2021
DOI: 10.3171/case2150
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Adamantinomatous craniopharyngioma associated with a compromised blood–brain barrier: patient series

Abstract: BACKGROUND Adamantinomatous craniopharyngioma (ACP) is a highly morbid adult and pediatric brain tumor derived from epithelial remnants of the craniopharyngeal canal (Rathke’s pouch), which gives rise to the anterior pituitary gland. Standard therapy includes maximal safe resection with or without radiation therapy. Systemic antitumor therapy remains elusive. Immune-related paracrine signaling involving the interleukin-6 receptor (IL-6R) may contribute to ACP pathogenesis. Tocilizumab, a recombinant humanized … Show more

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Cited by 2 publications
(2 citation statements)
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“…24) Nevertheless, tocilizumab is not believed to cross the blood-brain barrier because of its high molecular weight. 25) Hence, these findings cannot be directly applied to CNS diseases. The immunohistochemi-…”
Section: Discussionmentioning
confidence: 99%
“…24) Nevertheless, tocilizumab is not believed to cross the blood-brain barrier because of its high molecular weight. 25) Hence, these findings cannot be directly applied to CNS diseases. The immunohistochemi-…”
Section: Discussionmentioning
confidence: 99%
“…The feasibility of tocilizumab, a monoclonal antibody against IL-6, is currently being explored. 86 , 87 …”
Section: Role Of Radiotherapy and How It Can Be Tailored Based On Ris...mentioning
confidence: 99%