We establish several Poincaré-Sobolev type inequalities for the Lapalce-Beltrami operator ∆ g in the hyperbolic space H n with n ≥ 5. These inequalities could be seen as the improved second order Poincaré inequality with remainder terms involving with the sharp Rellich inequality or sharp Sobolev inequality in H n . The novelty of these inequalities is that it combines both the sharp Poincaré inequality and the sharp Rellich inequality or the sharp Sobolev inequality for ∆ g in H n . As a consequence, we obtain the Poincaré-Sobolev inequality for the second order GJMS operator P 2 in H n . In dimension 4, we obtain an improvement of the sharp Adams inequality and an Adams inequality with exact growth for radial functions in H 4 .