ADAMTS14 gene polymorphism associated with knee osteoarthritis in Thai women

Poonpet, Thitiya; Honsawek, Sittisak; Tammachote, Nattapol; Kanitnate, Supakit; Tammachote, Rachaneekorn

doi:10.4238/2013.november.7.5

Cited by 34 publications

(30 citation statements)

References 28 publications

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“…Single nucleotide polymorphisms (SNPs) of ADAMTS14 have been associated with an increased risk of knee OA in two female cohorts32, 33. The enzyme may be differently regulated in murine OA models, since little regulation is observed in most murine microarray studies, other than reduced expression observed by Bateman et al.…”

Section: Adamtssmentioning

confidence: 99%

ADAMTS and ADAM metalloproteinases in osteoarthritis – looking beyond the ‘usual suspects’

Yang

Chanalaris

Troeberg

2017

Osteoarthritis and Cartilage

228

164

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SummaryIntroductionMatrix metalloproteinases (MMPs) and ‘aggrecanase’ a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs) are well established to play key roles in osteoarthritis (OA) through degradation of extracellular matrix (ECM) type II collagen and aggrecan, and are thus potential targets for development of OA therapies.ObjectiveThis paper aims to provide a comprehensive review of the expression and potential roles of other, lesser-known ADAMTSs and related adamalysins (or a disintegrin and metalloproteinases (ADAMs)) in cartilage, with a view to identifying potentially protective or homeostatic metalloproteinases in the joint and informing consequent selective inhibitor design.DesignA comprehensive literature search was performed using PubMed terms ‘osteoarthritis’ and ‘ADAMTS’ or ‘ADAM’.ResultsSeveral ADAMTSs and ADAMs were identified as having reportedly increased expression in OA. These include enzymes likely to play roles in cartilage matrix anabolism (e.g., the procollagen N-proteinases ADAMTS-2, ADAMTS-3 and ADAMTS-14), chondrocyte differentiation and proliferation (e.g., ADAM9, ADAM10, ADAM12), as well as enzymes contributing to cartilage catabolism (e.g., Cartilage oligomeric protein (COMP)-degrading ADAMTS-7 and ADAMTS-12).ConclusionsIn addition to the well-characterised MMPs, ADAMTS-4 and ADAMTS-5, many other ADAMTSs and ADAMs are expressed in cartilage and several show significantly altered expression in OA. Studies aimed at elucidating the pathophysiological roles of these enzymes in cartilage will contribute to our understanding of OA pathogenesis and enable design of targeted inhibitors that effectively target metalloproteinase-mediated cartilage degradation while sparing cartilage repair pathways.

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Section: Adamtssmentioning

confidence: 99%

ADAMTS and ADAM metalloproteinases in osteoarthritis – looking beyond the ‘usual suspects’

Yang

Chanalaris

Troeberg

2017

Osteoarthritis and Cartilage

228

164

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“…An augmented expression of this protease along with ADAMTS14 has also been described in OA [165,166]. In this regard, two polymorphisms have been identified in the ADAMTS14 gene associated with an increased risk of knee OA in woman [167,168]. However, the role played by these proteases in rheumatic pathologies is still quite unknown and more studies are needed.…”

Section: Procollagen N-propeptidasesmentioning

confidence: 99%

Profile of Matrix-Remodeling Proteinases in Osteoarthritis: Impact of Fibronectin

Pérez‐García

Carrión

Gutiérrez‐Cañas

et al. 2019

Cells

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The extracellular matrix (ECM) is a complex and specialized three-dimensional macromolecular network, present in nearly all tissues, that also interacts with cell surface receptors on joint resident cells. Changes in the composition and physical properties of the ECM lead to the development of many diseases, including osteoarthritis (OA). OA is a chronic degenerative rheumatic disease characterized by a progressive loss of synovial joint function as a consequence of the degradation of articular cartilage, also associated with alterations in the synovial membrane and subchondral bone. During OA, ECM-degrading enzymes, including urokinase-type plasminogen activator (uPA), matrix metalloproteinases (MMPs), and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs), cleave ECM components, such as fibronectin (Fn), generating fibronectin fragments (Fn-fs) with catabolic properties. In turn, Fn-fs promote activation of these proteinases, establishing a degradative and inflammatory feedback loop. Thus, the aim of this review is to update the contribution of ECM-degrading proteinases to the physiopathology of OA as well as their modulation by Fn-fs.

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“…In one study, genetic variation in human ADAMTS5 did not seem to affect OA susceptibility (Rodriguez-Lopez et al, 2008); however, a separate investigation reached the opposite conclusion (Gu et al, 2013). Moreover, a non-synonymous single nucleotide polymorphism (SNP) of ADAMTS14 (rs4747096) has been shown to be associated with knee OA in Thai women (Poonpet et al, 2013). To the best of our knowledge, no study associating ADAMTS4 gene polymorphism with knee OA has been reported.…”

Section: Introductionmentioning

confidence: 97%

Polymorphisms in ADAMTS4 and ADAMTS5 are not linked to susceptibility to knee osteoarthritis in the Turkish population

et al. 2016

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ABSTRACT. Considering the functions of aggrecanase-1 (ADAMTS4) and -2 (ADAMTS5), which are thought to be the two major enzymes responsible for the destruction of aggrecans in arthritic diseases, we investigated whether important polymorphisms in the ADAMTS4 and ADAMTS5 genes affect osteoarthritis (OA) susceptibility. Our study took place in Mugla, Turkey. Ninety-five cases were recruited following OA diagnosis (72 women and 23 men), and 80 individuals without any symptoms or radiographic signs of OA (56 women and 24 men) were chosen as healthy controls. After obtaining DNA from patients and control subjects, ADAMTS4 and ADAMTS5 genotypes were determined using the ABI Prism StepOnePlus Real-Time system. In addition, we categorized patients based on OA grade. There were no significant differences in the genotype distributions of the four polymorphisms between the groups (P > 0.05). Moreover, ADAMTS4 and ADAMTS5 allele frequencies did not differ between OA and control participants (P > 0.05). These findings suggest that the ADAMTS4 (rs4233367 and rs11807350) and ADAMTS5 (rs226794 and rs2830585) variants examined may not contribute to susceptibility to knee OA in the Turkish population. Other gene polymorphisms should be assessed in order to explain variations in OA susceptibility.

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ADAMTS14 gene polymorphism associated with knee osteoarthritis in Thai women

Cited by 34 publications

References 28 publications

ADAMTS and ADAM metalloproteinases in osteoarthritis – looking beyond the ‘usual suspects’

ADAMTS and ADAM metalloproteinases in osteoarthritis – looking beyond the ‘usual suspects’

Profile of Matrix-Remodeling Proteinases in Osteoarthritis: Impact of Fibronectin

Polymorphisms in ADAMTS4 and ADAMTS5 are not linked to susceptibility to knee osteoarthritis in the Turkish population

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