ADAMTS9, a member of the ADAMTS family, in Xenopus development

Desanlis, Inès; Felstead, Hannah L.; Edwards, Dylan R.; Wheeler, Grant N.

doi:10.1016/j.gep.2018.06.001

Cited by 13 publications

(9 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, ADAMTS9, a matrix metalloproteinase whose function is conserved in vertebrates (Christian et al. 2013; Desanlis et al. 2018), is hypomethylated in embryos of early domesticate sea bass (fig.…”

Section: Resultsmentioning

confidence: 99%

Epimutations in Developmental Genes Underlie the Onset of Domestication in Farmed European Sea Bass

Anastasiadi

Piferrer

2019

Molecular Biology and Evolution

View full text Add to dashboard Cite

Domestication of wild animals induces a set of phenotypic characteristics collectively known as the domestication syndrome. However, how this syndrome emerges is still not clear. Recently, the neural crest cell deficit hypothesis proposed that it is generated by a mildly disrupted neural crest cell developmental program, but clear support is lacking due to the difficulties of distinguishing pure domestication effects from preexisting genetic differences between farmed and wild mammals and birds. Here, we use a farmed fish as model to investigate the role of persistent changes in DNA methylation (epimutations) in the process of domestication. We show that early domesticates of sea bass, with no genetic differences with wild counterparts, contain epimutations in tissues with different embryonic origins. About one fifth of epimutations that persist into adulthood are established by the time of gastrulation and affect genes involved in developmental processes that are expressed in embryonic structures, including the neural crest. Some of these genes are differentially expressed in sea bass with lower jaw malformations, a key feature of domestication syndrome. Interestingly, these epimutations significantly overlap with cytosine-to-thymine polymorphisms after 25 years of selective breeding. Furthermore, epimutated genes coincide with genes under positive selection in other domesticates. We argue that the initial stages of domestication include dynamic alterations in DNA methylation of developmental genes that affect the neural crest. Our results indicate a role for epimutations during the beginning of domestication that could be fixed as genetic variants and suggest a conserved molecular process to explain Darwin’s domestication syndrome across vertebrates.

show abstract

Section: Resultsmentioning

confidence: 99%

Epimutations in Developmental Genes Underlie the Onset of Domestication in Farmed European Sea Bass

Anastasiadi

Piferrer

2019

Molecular Biology and Evolution

View full text Add to dashboard Cite

show abstract

“…4c, d). In particular, Adamts1 expression was markedly increased, whereas Adamts2 and -8 expressions, which are presumably important in cancer cell invasion [87][88][89], increased in the later stages of differentiation.…”

Section: Metzincin Superfamily Zinc Proteinase and Protocadherin Supementioning

confidence: 96%

Stage-dependent differential gene expression profiles of cranial neural crest-like cells derived from mouse-induced pluripotent stem cells

et al. 2019

View full text Add to dashboard Cite

Cranial neural crest cells are multipotent cells that migrate into the pharyngeal arches of the vertebrate embryo and differentiate into various craniofacial organ derivatives. Therefore, migrating cranial neural crest cells are considered one of the most attractive candidate cell sources in regenerative medicine. We generated cranial neural crest like cell (cNCCs) using mouse-induced pluripotent stem cells cultured in neural crest-inducing medium for 14 days. Subsequently, we conducted RNA sequencing experiments to analyze gene expression profiles of cNCCs at different time points after induction. cNCCs expressed several neural crest specifier genes; however, some previously reported specifier genes such as paired box 3 and Forkhead box D3, which are essential for embryonic neural crest development, were not expressed. Moreover, ETS protooncogene 1, transcription factor and sex-determining region Y-box 10 were only expressed after 14 days of induction. Finally, cNCCs expressed multiple protocadherins and a disintegrin and metalloproteinase with thrombospondin motifs enzymes, which may be crucial for their migration.

show abstract

“…Because of the expression of ADAMTS9 in the brain, the craniofacial structures are similar for mice and Xenopus [ 20 ]. Desanlis et al studied the possible role of ADAMTS9 in human development by studying the role of ADAMTS9 in Xenopus development [ 21 ]. They found that ADAMTS9 is highly expressed from early tailbud in various regions, especially in the midbrain-hindbrain boundary, and the migrating cells along the branchial arches and at tadpole stages.…”

Section: Discussionmentioning

confidence: 99%

Association of Polymorphism rs67920064 in ADAMTS9 Gene with Mandibular Retrognathism in a Chinese Population

Wang

Cai

et al. 2020

Med Sci Monit

View full text Add to dashboard Cite

ADAMTS9, a member of the ADAMTS family, in Xenopus development

Cited by 13 publications

References 36 publications

Epimutations in Developmental Genes Underlie the Onset of Domestication in Farmed European Sea Bass

Epimutations in Developmental Genes Underlie the Onset of Domestication in Farmed European Sea Bass

Stage-dependent differential gene expression profiles of cranial neural crest-like cells derived from mouse-induced pluripotent stem cells

Association of Polymorphism rs67920064 in ADAMTS9 Gene with Mandibular Retrognathism in a Chinese Population

Contact Info

Product

Resources

About