Adapalene gel 0.1% vs ketoconazole cream 2% and their combination in treatment of pityriasis versicolor: A randomized clinical study

Bakr, Essam; Abdo, Hamed Mohamed; Abd-Elaziz, Hassan Mamdouh; Abd-Elrazek, Hazem; Amer, Mohamed

doi:10.1111/dth.13319

Cited by 10 publications

(10 citation statements)

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“…The antiproliferative effect of ADP can be exploited in the treatment of some cancer types [ 22 , 23 , 24 , 25 , 26 ]. In addition to topical combinations of ADP and other active pharmaceutical ingredients (APIs) [ 20 , 27 , 28 ], new therapeutic combinations with orally administered APIs were also reported with good effectiveness [ 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances Regarding the Therapeutic Potential of Adapalene

et al. 2020

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Adapalene (ADP) is a representative of the third retinoids generation and successfully used in first-line acne treatment. ADP binds to retinoic acid nuclear receptors. The comedolytic, anti-inflammatory, antiproliferative, and immunomodulatory are the known ADP effects. Its safety profile is an advantage over other retinoids. ADP recently was found to be effective in the treatment of several dermatological diseases and photoaging besides the utility in the treatment of acne vulgaris. New biological effects of adapalene with therapeutic potential are highlighted in this review paper. Thus, adapalene could be a valuable therapeutic drug into the treatment of several types of cancer. Additionally, some neurodegenerative diseases could be treated with a suitable formulation for intravenous administration. The antibacterial activity against methicillin-resistant Staphylococcus aureus of an analogue of ADP has been proven. In different therapeutic schemes, ADP is more effective in combination with other active substances. New topical combinations with adapalene include ketoconazole (antifungal), mometasone furoate (anti-inflammatory corticosteroid), nadifloxacin (fluoroquinolone), and alfa and beta hydroxy acids. Combination with oral drugs is a new trend that enhances the properties of topical formulations with adapalene. Several studies have investigated the effects of ADP in co-administration with azithromycin, doxycycline, faropenem, isotretinoin, and valganciclovir. Innovative formulations of ADP also aim to achieve a better bioavailability, increased efficacy, and reduced side effects. In this review, we have highlighted the current studies on adapalene regarding biological effects useful in various treatment types. Adapalene has not been exploited yet to its full biological potential.

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Section: Introductionmentioning

confidence: 99%

Recent Advances Regarding the Therapeutic Potential of Adapalene

et al. 2020

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“…166 Studies have shown that combination therapies using 2% ketoconazole cream and 1% adapalene gel are more efficacious in the treatment of tinea versicolor than ketoconazole cream alone. 171,172 To further improve the efficacy of topical ketoconazole, future drug development should focus on improving topical delivery to allow better permeation of drugs into skin by using nanostructured lipid carriers, nanoparticles, microemulsions, copolymeric micelles, niosomes and microemulsions. 156,[173][174][175][176] In this regard, the development of topical gels containing fluconazole-loaded solid lipid nanoparticles allows fluconazole to be used topically as the product exhibits skin penetration as a result of large particle surface area and film formation, enhancing contact between fluconazole and skin.…”

Section: Topical Antifungalsmentioning

confidence: 99%

Tinea versicolor: an updated review

Leung¹,

Barankin²,

Lam³

et al. 2022

DIC

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A search was conducted in July 2022 in PubMed Clinical Queries using the key terms "tinea versicolor" OR "pityriasis versicolor". The search strategy included all clinical trials (including open trials, non-randomized controlled trials and randomized controlled trials), observational studies and reviews (including narrative reviews and meta-analyses) published within the past 10 years. Only papers published in the English literature were included in this review. The information retrieved from the search was used in the compilation of this article. Review AetiopathogenesisTinea versicolor is caused by dimorphic lipophilic and lipid-dependent yeasts in the genus Malassezia (formerly known as Pityrosporum) species, notably Malassezia globosa (M. globose), M. furfur and M. sympodialis. [2][3][4][5][6][7][8][9][10][11][12] Other species that have been implicated include M. restricta, M. obtuse, M. slooffiae, M. pachydermatis and M. japonica. [13][14][15][16] These yeasts are normal commensals on the skin surface. 17,18 Skin colonization increases with age; 25% of children and almost 100% of adults are affected. 19 Tinea versicolor occurs when the saprophytic yeast or budding form of the organism converts to the pathogenic hyphal or mycelial form. The fungal infection is localized to the stratum corneum. Predisposing factors for the conversion include a hot and humid environment, hyperhidrosis, application of oily lotion or cream to the skin, wearing of masks, excessive lipid-containing sebaceous secretions, malnutrition, poor general health, use of oral contraceptives, pregnancy, diabetes mellitus, use of topical or systemic corticosteroids, Cushing disease, Helicobacter pylori infection, immunodeficiency and genetic predisposition. [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] A recent study showed oxidative stress has no role in the pathogenesis of tinea versicolor. 29

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“…Many other retinoids, including alitretinoin and bexarotene, are effective against mycosis fungoides and Kaposi's sarcoma. Thanks to their RXR-targeting properties (8) .…”

Section: Mechanism Of Actionmentioning

confidence: 99%

An Insight of Use of Topical Adapalene in Management of Post Acne Scars: Review Article

Hamed¹,

Atwa²,

Amer³

2022

The Egyptian Journal of Hospital Medicine

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Background: This inflammatory condition affects the pilosebaceous unit, causing comedones, inflammatory papules, and pustules to appear on the face, chest, and back. Propionibacterium acnes and inflammation surrounding the pilosebaceous unit, aberrant keratinization, and increased sebum production all play a role in acne's pathophysiology. Scarring from acne and acne can lead to low self-esteem and feelings of embarrassment, all of which have a negative impact on one's overall wellbeing. Objective: To see if topical adapalene can help with post-acne scar treatment. Methods: The databases were searched for articles published in English in 4 data bases [PubMed -Google scholar-Egyptian Knowledge Bank -Science direct] and Boolean operators (AND, OR, NOT) had been used such as topical adapalene and post acne scars OR acne scar treatment and in peer-reviewed articles between January 2000 and March 2021. Documents in a language apart from English have been excluded as sources for interpretation was not found. Papers apart from main scientific studies had been excluded (documents unavailable as total written text, conversation, conference abstract papers and dissertations). Results: Anti-acne retinoid adapalene (ADP) was licensed by the FDA in 1996 for use in treating acne. It improves the appearance of the skin of the face by reducing facial lesions. Acne lesions, both inflammatory and noninflammatory, respond well to adapalene gel treatment. In terms of adverse effects, the medicine is completely safe and does not cause burning or dryness. Conclusion: It is possible that adapalene, which has been shown to be effective in the therapy of photoaging-related skin damage, could have a similar effect on the treatment of atrophic acne scars.

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Adapalene gel 0.1% vs ketoconazole cream 2% and their combination in treatment of pityriasis versicolor: A randomized clinical study

Cited by 10 publications

References 10 publications

Recent Advances Regarding the Therapeutic Potential of Adapalene

Recent Advances Regarding the Therapeutic Potential of Adapalene

Tinea versicolor: an updated review

An Insight of Use of Topical Adapalene in Management of Post Acne Scars: Review Article

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