Adaptation in human zinc absorption as influenced by dietary zinc and bioavailability

Hunt, John; Beiseigel, Jeannemarie M.; Johnson, LuAnn K.

doi:10.1093/ajcn/87.5.1336

Cited by 87 publications

(80 citation statements)

References 26 publications

(57 reference statements)

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“…This fi nding is not unexpected as the diets of the women in both EPAs were low in zinc with high phytate-to-zinc molar ratios, and the inhibitory effect of phytate on zinc absorption in adults is now thought to be much larger than previously estimated [24] [32]. Moreover, there is no evidence of an adaptive response to habitual high phytate intakes on zinc absorption [33]. Nevertheless, the predicted risk of zinc defi ciency based on low plasma zinc concentrations was higher than predicted from zinc intakes.…”

Section: Zinc Statusmentioning

confidence: 81%

A High Prevalence of Zinc- but not Iron-Deficiency among Women in Rural Malawi: a Cross-Sectional Study

Siyame

Hurst

Wawer

et al. 2013

International Journal for Vitamin and Nutrition Research

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Abstract:Background: Zinc defi ciency is often associated with nutritional iron defi ciency (ID), and may be exacerbated by low selenium status. Aim: To investigate risk of iron and zinc defi ciency in women with contrasting selenium status. Methods: In a cross-sectional study, 1-day diet composites and blood samples were collected from self-selected Malawian women aged 18−50 years from low-(Zombwe) (n=60) and high-plant-available soil selenium (Mikalango) (n=60) districts. Diets were analyzed for trace elements and blood for biomarkers. Results: Zinc defi ciency (>90 %) was greater than ID anemia (6 %), or ID (5 %), attributed to diets low in zinc (median 5.7 mg/day) with high phytate:zinc molar ratios (20.0), but high in iron (21.0 mg/day) from soil contaminant iron. Zombwe compared to Mikalango women had lower (p<0.05) intakes of selenium (6.5 vs. 55.3 μg/day), zinc (4.8 vs. 6.4 mg/day), iron (16.6 vs. 29.6 mg/day), lower plasma selenium (0.72 vs. 1.60 μmol/L), and higher body iron (5.3 vs. 3.8 mg/kg), although plasma zinc was similar (8.60 vs. 8.87 μmol/L). Body iron and plasma zinc were positive determinants of hemoglobin. Conclusion: Risk of zinc defi ciency was higher than ID and was shown not to be associated with selenium status. Plasma zinc was almost as important as body iron as a hemoglobin determinant.

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Section: Zinc Statusmentioning

confidence: 81%

A High Prevalence of Zinc- but not Iron-Deficiency among Women in Rural Malawi: a Cross-Sectional Study

Siyame

Hurst

Wawer

et al. 2013

International Journal for Vitamin and Nutrition Research

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“…It is known that zinc absorption is affected by zinc status and that absorption efficiency is inversely correlated with the amount of ingested zinc [51]. Hunt et al showed that healthy humans, consuming low-zinc diets, increase zinc absorption, which was controlled by the ingested zinc dose [52]. This adaptation to zinc absorption is not possible after malabsorptive surgery.…”

Section: Discussionmentioning

confidence: 99%

Zinc Deficiency: A Frequent and Underestimated Complication After Bariatric Surgery

Sallé

Demarsy

Poirier³

et al. 2010

OBES SURG

109

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“…For example, with only 900 mg phytate intake/d, the model predicts that it will require 100 mg ingested Zn to achieve this quantity of absorbed zinc (18). This model has also been used to develop recommendations for the zinc fortification of flour from a range of cereal grains (19); to predict the increase in absorbed zinc from a zinc-biofortified cereal (20,21); and to assist in the evaluation of data derived from experimental human studies in which quantities of ingested zinc and phytate were manipulated (22). The last research was also then used to evaluate this trivariate model, an evaluation that proved to be strongly supportive of the model in contrast to another purely mathematic model (23).…”

Section: Effect Of Dietary Phytate On the Bioavailability Of Ingestedmentioning

confidence: 99%

“…As additional total diet data are identified and new data are published that include phytate intake, these data have been added to the original data set of 21 to give a current total of 72 data sets (means) (Figure 2) (6,9,17,18,20,22,24). The parameters of the current model have been compared with the corresponding values for the original model ( Table 1) and indicate further improvement in the certainty of the estimates, which include a lower A MAX .…”

Section: Effect Of Dietary Phytate On the Bioavailability Of Ingestedmentioning

confidence: 99%

Zinc bioavailability and homeostasis

Hambidge¹,

Miller²,

Westcott³

et al. 2010

The American Journal of Clinical Nutrition

217

149

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Zinc has earned recognition recently as a micronutrient of outstanding and diverse biological, clinical, and global public health importance. Regulation of absorption by zinc transporters in the enterocyte, together with saturation kinetics of the absorption process into and across the enterocyte, are the principal means by which whole-body zinc homeostasis is maintained. Several physiologic factors, most notably the quantity of zinc ingested, determine the quantity of zinc absorbed and the efficiency of absorption. Other factors are age and the time over which zinc is ingested. Zinc from supplements has not been shown to be absorbed differently from that taken with meals that lack inhibitors of zinc absorption. The principal dietary factor known to impair zinc bioavailability is inositol hexa-(and penta-) phosphate or phytate. Modeling of zinc absorption as a function of dietary zinc and phytate accounts for .80% of the variability in the quantity of zinc absorbed. Fitting the model to new data has resulted in continual improvement in parameter estimates, which currently indicate a maximal absorption in adults of '6 mg Zn/d and that the average estimated dietary requirement doubles with 1000 mg dietary phytate/d. Intestinal excretion of endogenous zinc is regulated in response to recent absorption and to zinc status. The quantitative relation of intestinal excretion of endogenous zinc to zinc absorption is currently considered to be of major importance in the determination of zinc requirements. The effects of phytate on intestinal losses of endogenous zinc merit further investigation but are probably not of the same magnitude as its inhibitory effects on absorption of exogenous zinc.Am J Clin Nutr 2010;91(suppl): 1478S-83S.

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Adaptation in human zinc absorption as influenced by dietary zinc and bioavailability

Cited by 87 publications

References 26 publications

A High Prevalence of Zinc- but not Iron-Deficiency among Women in Rural Malawi: a Cross-Sectional Study

A High Prevalence of Zinc- but not Iron-Deficiency among Women in Rural Malawi: a Cross-Sectional Study

Zinc Deficiency: A Frequent and Underestimated Complication After Bariatric Surgery

Zinc bioavailability and homeostasis

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