Adaptation of blood pressure to continuous heavy coffee drinking in young volunteers. A double‐blind crossover study.

Ammon, H. P. T.; Bieck, P. R.; Mandalaz, D.; Verspohl, E. J.

doi:10.1111/j.1365-2125.1983.tb01553.x

Cited by 85 publications

(39 citation statements)

References 13 publications

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“…The effects of repeated caffeine intake have also been studied in controlled studies using continuous ambulatory monitoring to measure blood pressure (Table 4). Some of the long-term studies have shown that caffeine induced persistent pressor effects (by 3 ± 6 mmHg) in habitual consumers (Ammon et al, 1983;Burr et al, 1989;James, 1994;Rakic et al, 1999). Changing from caffeinated to decaffeinated coffee (van Dusseldorp et al, 1989;Superko et al, 1994) or abstinence from coffee (Bak & Grobbee, 1990;Superko et al, 1994) resulted in a slight fall (by 2 ± 5 mmHg) in blood pressure.…”

Section: Acute Intake Of Coffee or Caffeine And Blood Pressurementioning

confidence: 99%

“…The pressor response has been reported as diminishing within a few days of the start of regular intake of caffeine (Robertson et al, 1981(Robertson et al, , 1984Ammon et al, 1983;Myers & Reeves, 1991). However, the tolerance may be partial, because in some studies caffeine was still able to elevate blood pressure during habitual consumption (Burr et al, 1989;Jeong & Dimsdale 1990;James 1994;Green & Suls, 1996).…”

Section: Acute Intake Of Coffee or Caffeine And Blood Pressurementioning

confidence: 99%

“…The pressor effect has often been accompanied by a small decrease in the heart rate (Izzo et al, 1983;Smits et al, 1983Smits et al, , 1985Smits et al, , 1986aRobertson et al, 1984;Sung et al, 1994), or heart rate was not sign®cantly affected even after high doses of caffeine (Robertson et al, 1981;Ammon et al, 1983;Casiglia et al, 1992;Bender et al, 1997). The caffeineinduced lowering of the heart rate may be a re¯ectory bradycardic response to pressor action or a direct effect on the cardiac or sino-atrial node.…”

Section: Hemodynamic Effects Of Caffeinementioning

confidence: 99%

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Coffee, caffeine and blood pressure: a critical review

et al. 1999

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Objective: We review the published data relating to intake of coffee and caffeine on blood pressure in man. We also refer to studies on the possible mechanisms of actions of these effects of caffeine. Design: The MEDLINE and Current Contents databases were searched from 1966 to April 1999 using the text words`coffee or caffeine' and`blood pressure or hypertension'. Controlled clinical and epidemiologic studies on the blood pressure effects of coffee or caffeine are reviewed. We also refer to studies on the possible mechanisms of action of these effects of caffeine. Results: Acute intake of coffee and caffeine increases blood pressure. Caffeine is probably the main active component in coffee. The pressor response is strongest in hypertensive subjects. Some studies with repeated administration of caffeine showed a persistent pressor effect, whereas in others chronic caffeine ingestion did not increase blood pressure. Epidemiologic studies have produced contradictory ®ndings regarding the association between blood pressure and coffee consumption. During regular use tolerance to the cardiovascular responses develops in some people, and therefore no systematic elevation of blood pressure in long-term and in population studies can be shown. Conclusions:We conclude that regular coffee may be harmful to some hypertension-prone subjects. The hemodynamic effects of chronic coffee and caffeine consumption have not been suf®ciently studied. The possible mechanisms of the cardiovascular effects of caffeine include the blocking of adenosine receptors and the inhibition of phosphodiesterases.

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Section: Acute Intake Of Coffee or Caffeine And Blood Pressurementioning

confidence: 99%

Section: Acute Intake Of Coffee or Caffeine And Blood Pressurementioning

confidence: 99%

Section: Hemodynamic Effects Of Caffeinementioning

confidence: 99%

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Coffee, caffeine and blood pressure: a critical review

et al. 1999

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“…Caffeine is often regarded as a cardiovascular risk factor; however, there is conflicting epidemiological evidence on the relation of caffeine consumption to the occurrence of acute cardiovascular events (6)(7)(8)(9)(10)(11)(12)(13). The conflicting evidence may in part be due to the various pleiotropic effects caffeine has on cells at physiologically achievable concentrations.…”

Section: Introductionmentioning

confidence: 99%

Caffeine induces endothelial tissue factor expression via phosphatidylinositol 3-kinase inhibition

Gebhard¹,

Holy²,

Camici³

et al. 2012

Thromb Haemost

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SummaryTissue factor (TF) is the key activator of coagulation and is involved in acute coronary syndromes. Caffeine is often reported to increase cardiovascular risk; however, its effect on cardiovascular morbidity and mortality is controversial. Hence, this study was designed to investigate the impact of caffeine on endothelial TF expression in vitro. Caffeine concentration-dependently enhanced TF protein expression and surface activity in human endothelial cells stimulated by tumour necrosis factor (TNF)-α or thrombin. Caffeine inhibited phosphatidylinositol 3-kinase (PI3K) activity and this effect was comparable to that of the known PI3K inhibitor LY294002. Consistently, treatment of endothelial cells with LY294002 enhanced TNF-α induced TF expression to a similar extent as caffeine, and adenoviral expression of the active PI3K mutant (p110) reversed the effect of both caffeine and LY294002 on TF expression. Caffeine and LY294002 increased DNA binding capacity of the transcription factor nuclear factor κB, whereas the activation pattern of mitogen-activated protein kinases (MAPK) remained unaltered. Luciferase reporter assay revealed a caffeine dependent activation of the TF promoter, and RT-PCR revealed a dose dependent increase in TF mRNA levels when stimulated with caffeine in the presence of TNF-α. In conclusion, caffeine enhances TNF-α-induced endothelial TF protein expression as well as surface activity by inhibition of PI3K signalling. Since the caffeine concentrations applied in the present study are within the plasma range measured in humans, our findings indicate that caffeine enhances the prothrombotic potential of endothelial cells and underscore the importance of PI3K in mediating these effects.

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“…A switch to caffeine produced a small increase in blood pressure during the first few days, with levels falling and returning to baseline thereafter. We did not observe a transient rise in blood pressure, possibly because we measured blood pressure weekly, whereas Ammon et al 7 took blood pressure measurements every day. Robertson and colleagues 18 -19 also observed complete tolerance to caffeine after 7 days of caffeine ingestion.…”

mentioning

confidence: 73%

Effect of decaffeinated versus regular coffee on blood pressure. A 12-week, double-blind trial.

et al. 1989

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The effect of decaffeinated versus regular coffee on blood pressure and heart rate was investigated. In a randomized double-blind, crossover trial, 45 healthy volunteers (23 women and 22 men, 25-45 years old) with a habitual intake of 4-6 cups coffee/day received 5 cups of regular coffee each day for a period of 6 weeks, and 5 cups of decaffeinated coffee for the next 6 weeks or vice versa. The background diet was kept constant. The total amount of caffeine ingested was 40 mg during the decaffeinated coffee period and 445 mg during the regular coffee period. Use of decaffeinated coffee led to a significant but small decrease in systolic (mean±SEM, -1 . 5 ± 0 . 4 mm Hg; />=0.002) and diastolic (-1.0±0.4 mm Hg; p=0.017) ambulant blood pressure and to a small increase in ambulant heart rate (+1.3±0.6 beats/min; p=0.031). Individual differences in rate of caffeine metabolism did not explain differences in long-term response of blood pressure to caffeine. We conclude that in normotensive adults replacement of regular by decaffeinated coffee leads to a real but small fall in blood pressure. However, it remains to be established whether a mass switch from regular to decaffeinated coffee would significantly reduce the total incidence of hypertension-related disorders. (Hypertension 1989;14:563-569) C offee is the most widely used stimulant in Western society. In the Netherlands, 94% of adults drink at least 1 cup/day, and the per capita intake is 4.5 cups/day.1 An increasing proportion of consumers is switching from regular to decaffeinated coffee. In the Netherlands, the market share of decaffeinated coffee grew from 2% in 1984 to 4% in 1987. In the United States, the proportion is already 20%.2 The switch is motivated partly by the well-documented negative effects of caffeine on the quality of sleep and partly by other purported negative effects, including those on the cardiovascular system. However, surprisingly little is known about the actual long-term effect of switching to decaffeinated coffee and how this switch will affect risk factors for coronary heart disease.Epidemiological surveys on the relation between coffee consumption and blood pressure have yielded Supported by Grant 87.026 from the Netherlands Heart Foundation. The coffee was a gift of the Dutch association of coffee toasters and tea packers.Received May 2, 1989; accepted in revised form June 29,1989. contradictory findings.3 -5 Controlled trials showed that in subjects who have abstained from caffeine for a number of days blood pressure rises acutely after a caffeine load. The extent of this acute pressor effect of caffeine depends on the amount and frequency of previous caffeine intake and on the rate of caffeine metabolism; subjects with a high coffee intake appear to be less sensitive to the pressure-elevating effect of caffeine.6 This was confirmed by one experiment that showed no effect of caffeine consumption on blood pressure after 4 weeks 7 ; however, the diet was not controlled, and the power of this trial was small.In the present study...

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Adaptation of blood pressure to continuous heavy coffee drinking in young volunteers. A double‐blind crossover study.

Cited by 85 publications

References 13 publications

Coffee, caffeine and blood pressure: a critical review

Coffee, caffeine and blood pressure: a critical review

Caffeine induces endothelial tissue factor expression via phosphatidylinositol 3-kinase inhibition

Effect of decaffeinated versus regular coffee on blood pressure. A 12-week, double-blind trial.

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