Adaptation of chicken vestibular nucleus neurons to unilateral vestibular ganglionectomy

Shao, Mei; Popratiloff, Anastas; Jing, Y. P.; Lerner, Alicja; Hirsch, J F; Peusner, Kenna D.

doi:10.1016/j.neuroscience.2009.04.027

Cited by 20 publications

(43 citation statements)

References 60 publications

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“…The MAP2 antibody was monoclonal anti-MAP2 from Millipore (clone AP20) that was raised in mouse using the bovine brain microtubule protein, cross reacts with chicken protein, and been shown to densely label cell bodies and primary dendrites of neurons in chicken brain stem (Shao et al 2009;Wang and Rubel 2008).…”

Section: Map2 Antibody Specificitymentioning

confidence: 99%

Heterogeneous Calretinin Expression in the Avian Cochlear Nucleus Angularis

Bloom

Williams

MacLeod

2014

JARO

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Multiple calcium-binding proteins (CaBPs) are expressed at high levels and in complementary patterns in the auditory pathways of birds, mammals, and other vertebrates, but whether specific members of the CaBP family can be used to identify neuronal subpopulations is unclear. We used double immunofluorescence labeling of calretinin (CR) in combination with neuronal markers to investigate the distribution of CR-expressing neurons in brainstem sections of the cochlear nucleus in the chicken (Gallus gallus domesticus). While CR was homogeneously expressed in cochlear nucleus magnocellularis, CR expression was highly heterogeneous in cochlear nucleus angularis (NA), a nucleus with diverse cell types analogous in function to neurons in the mammalian ventral cochlear nucleus. To quantify the distribution of CR in the total NA cell population, we used antibodies against neuronal nuclear protein (NeuN), a postmitotic neuronspecific nuclear marker. In NA neurons, NeuN label was variably localized to the cell nucleus and the cytoplasm, and the intensity of NeuN immunoreactivity was inversely correlated with the intensity of CR immunoreactivity. The percentage of CR+neurons in NA increased from 31 % in embryonic (E)17/18 chicks, to 44 % around hatching (E21), to 51 % in postnatal day (P) 8 chicks. By P8, the distribution of CR + neurons was uniform, both rostrocaudal and in the tonotopic (dorsoventral) axis.Immunoreactivity for the voltage-gated potassium ion channel Kv1.1, used as a marker for physiological type, showed broad and heterogeneous postsynaptic expression in NA, but did not correlate with CR expression. These results suggest that CR may define a subpopulation of neurons within nucleus angularis.

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Section: Map2 Antibody Specificitymentioning

confidence: 99%

Heterogeneous Calretinin Expression in the Avian Cochlear Nucleus Angularis

Bloom

Williams

MacLeod

2014

JARO

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“…The surgical protocol was adapted from previous studies (Aldrich and Peusner 2002;Pollack et al 2004;Shao et al 2009). After general anesthesia was obtained using ketamine (100 mg/kg; Fort Dodge Animal Health, Fort Dodge, IA) and xylazine (20 mg/kg; Akorn, Decatur, IL), an incision was made in the skin on the left side of the head posterior to the external auditory meatus.…”

Section: Uvgmentioning

confidence: 99%

“…However, by 3 days after UVG, most operated chickens could stand, feed, and drink independently, so they were considered "compensating chickens," whereas other operated chickens could not perform these activities so they were called "uncompensated chickens" (see Shao et al 2009). Indeed, after peripheral vestibular surgery, patients may fail to compensate (Halmagyi et al 2010).…”

Section: Uvgmentioning

confidence: 99%

“…rotransmitters are recorded in vestibular nuclei neurons from brain slices of rat (e.g., Yamanaka et al 2000;Him and Dutia 2001;Olabi et al 2009) and guinea pig after unilateral labyrinthectomy (UL; e.g., see Vibert et al 2000;Beraneck et al 2003Beraneck et al , 2004, and chicken after unilateral vestibular ganglionectomy (UVG; see Shao et al 2009). …”

mentioning

confidence: 99%

“…The bipedal chicken offers an important model to study vestibular compensation, since, like patients, most chickens start to recover from the static symptoms shortly after UVG (3 days; Aldrich and Peusner 2002), while a significant fraction fails to compensate (Shao et al 2009). In fact, ϳ20% of patients fail to recover after surgical unilateral vestibular deafferentation, experiencing persistent postural imbalance and dynamic reflex deficits (for review, see Badke et al 2002;Halmagyi et al 2010).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Plasticity of spontaneous excitatory and inhibitory synaptic activity in morphologically defined vestibular nuclei neurons during early vestibular compensation

Shao

Hirsch

Peusner

2012

Journal of Neurophysiology

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Interactions between intrinsic membrane and emerging network properties determine signal processing in central vestibular neurons

Rössert

2011

Exp Brain Res

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Head/body motion-related sensory signals are transformed in second-order vestibular neurons (2°VN) into commands for appropriate motor reactions that stabilize gaze and posture during locomotion. In all vertebrates, these neurons form functional subgroups with different membrane properties and response dynamics, compatible with the necessity to process a wide range of motion-related sensory signals. In frog, 2°VN subdivide into two well-defined populations with distinctly different intrinsic membrane properties, discharge dynamics and synaptic response characteristics. Tonic 2°VN form low-pass filters with membrane properties that cause synaptic amplification, whereas phasic 2°VN form band-pass filters that cause shunting of repetitive inputs. The different, yet complementary, filter properties render tonic neurons suitable for integration and phasic neurons for differentiation and event detection. Specific insertion of phasic 2°VN into local vestibular networks of inhibitory interneurons reinforces the functional consequences of the intrinsic membrane properties of this particular cell type with respect to the processing of afferent sensory signals. Thus, the combination of matching intrinsic cellular and emerging network properties generates sets of neuronal elements that form adjustable, frequency-tuned filter components for separate transformation of the various dynamic aspects of head motion-related signals. The overall frequency tuning of central vestibular neurons differs between vertebrates along with variations in species-specific locomotor dynamics, thereby illustrating an ecophysiological plasticity of the involved neuronal elements. Moreover, separation into multiple, dynamically different subtypes at any neuronal level along the vestibulo-motor reflex pathways suggests an organization of head motion-related sensory-motor transformation in parallel, frequency-tuned channels.

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Adaptation of chicken vestibular nucleus neurons to unilateral vestibular ganglionectomy

Cited by 20 publications

References 60 publications

Heterogeneous Calretinin Expression in the Avian Cochlear Nucleus Angularis

Heterogeneous Calretinin Expression in the Avian Cochlear Nucleus Angularis

Plasticity of spontaneous excitatory and inhibitory synaptic activity in morphologically defined vestibular nuclei neurons during early vestibular compensation

Interactions between intrinsic membrane and emerging network properties determine signal processing in central vestibular neurons

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