Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain

Geyer, Emily D.; Shetty, Prithvi A.; Suozzi, Christopher; Allen, David Z.; Benavidez, Pamela P.; Liu, Joseph; Hollis, Charles N.; Gerhardt, Greg A.; Quintero, Jorge E.; Burmeister, Jason J.; Whitaker, Emmett E.

doi:10.3791/57391

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…Longitudinal studies have been performed to examine the extent of glial scarring with various probe electrodes [61,62]. The stability and sensitivity of chronically implanted electrodes have been characterized for up to four months [63] and have been utilized in electrochemical characterization in vivo using rodent [41], pig [41,64], primate [62], and even human models [65]. Tissue damage during implantation can lead to glial encapsulation of the probe.…”

Section: In Vivo Sensingmentioning

confidence: 99%

Electrochemical Detection of Neurotransmitters

et al. 2020

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Neurotransmitters are important chemical messengers in the nervous system that play a crucial role in physiological and physical health. Abnormal levels of neurotransmitters have been correlated with physical, psychotic, and neurodegenerative diseases such as Alzheimer’s, Parkinson’s, dementia, addiction, depression, and schizophrenia. Although multiple neurotechnological approaches have been reported in the literature, the detection and monitoring of neurotransmitters in the brain remains a challenge and continues to garner significant attention. Neurotechnology that provides high-throughput, as well as fast and specific quantification of target analytes in the brain, without negatively impacting the implanted region is highly desired for the monitoring of the complex intercommunication of neurotransmitters. Therefore, it is crucial to develop clinical assessment techniques that are sensitive and reliable to monitor and modulate these chemical messengers and screen diseases. This review focuses on summarizing the current electrochemical measurement techniques that are capable of sensing neurotransmitters with high temporal resolution in real time. Advanced neurotransmitter sensing platforms that integrate nanomaterials and biorecognition elements are explored.

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Section: In Vivo Sensingmentioning

confidence: 99%

Electrochemical Detection of Neurotransmitters

et al. 2020

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“…Exceptional progress had been made towards electrochemical analysis of behaviorally relevant neurotransmitter signaling in the extracellular space as demonstrated by recordings in non-human primates [206,207] and swine [208]. In 2013, a new wireless sensing device coupled with voltammetric detection for electrochemical monitoring was demonstrated in a late-stage PD [209].…”

Section: Moving Into the Future: Recordings In Freely-moving Animalsmentioning

confidence: 99%

Approaches to Monitor Circuit Disruption after Traumatic Brain Injury: Frontiers in Preclinical Research

Krishna

Beitchman

Bromberg

et al. 2020

IJMS

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Mild traumatic brain injury (TBI) often results in pathophysiological damage that can manifest as both acute and chronic neurological deficits. In an attempt to repair and reconnect disrupted circuits to compensate for loss of afferent and efferent connections, maladaptive circuitry is created and contributes to neurological deficits, including post-concussive symptoms. The TBI-induced pathology physically and metabolically changes the structure and function of neurons associated with behaviorally relevant circuit function. Complex neurological processing is governed, in part, by circuitry mediated by primary and modulatory neurotransmitter systems, where signaling is disrupted acutely and chronically after injury, and therefore serves as a primary target for treatment. Monitoring of neurotransmitter signaling in experimental models with technology empowered with improved temporal and spatial resolution is capable of recording in vivo extracellular neurotransmitter signaling in behaviorally relevant circuits. Here, we review preclinical evidence in TBI literature that implicates the role of neurotransmitter changes mediating circuit function that contributes to neurological deficits in the post-acute and chronic phases and methods developed for in vivo neurochemical monitoring. Coupling TBI models demonstrating chronic behavioral deficits with in vivo technologies capable of real-time monitoring of neurotransmitters provides an innovative approach to directly quantify and characterize neurotransmitter signaling as a universal consequence of TBI and the direct influence of pharmacological approaches on both behavior and signaling.

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Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain

Cited by 2 publications

References 29 publications

Electrochemical Detection of Neurotransmitters

Electrochemical Detection of Neurotransmitters

Approaches to Monitor Circuit Disruption after Traumatic Brain Injury: Frontiers in Preclinical Research

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