Adaptation of Resistance Training is impaired in muscle-specific PGC-1α overexpressing mice
Hai Peng ZHANG,
Yan Lin SONG,
Rong Yan BAI
et al.
Abstract:Resistance training (RT) is important for skeletal muscle health. However, compared with RT implemented alone, concurrent training can attenuate RT adaptations. We verify the effects of RT on muscle-enriched or hypertrophy-related miRNAs, mammalian target of rapamycin complex 1 (mTORC1) anabolic signaling proteins, and oxidative metabolism-related proteins in mice with different endurance muscle Phenotype. In the present study, we found that muscle-specific overexpression of PGC-1alpha attenuated RT adaptation… Show more
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