Adaptation of the Framingham-Wilson Coronary Risk Equation for the Population of Navarra (RICORNA)

González-Diego, Paulino; Moreno‐Iribas, Conchi; Guembe, María Jesús; Viñes, J.J.; Vila, Joan

doi:10.1016/s1885-5857(09)72652-0

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…Este método consiste en mantener los mismos coeficientes de las ecuaciones de riesgo y sustituir los datos de prevalencia de factores de riesgo e incidencia de la enfermedad cardiovascular de la ecuación original por los datos locales de la población en la que se pretende aplicar. En España existen experiencias de recalibración de la ecuación de Framingham de 1998, como la del REGICOR 30 , Riesgo Coronario de Navarra (RICORNA) 33 , CDC-Canarias 34 y también de la ecuación del SCORE 35 .…”

Section: Tablas De Riesgo Cardiovascularunclassified

Recomendaciones preventivas cardiovasculares. Actualización PAPPS 2018

et al. 2018

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Section: Tablas De Riesgo Cardiovascularunclassified

Recomendaciones preventivas cardiovasculares. Actualización PAPPS 2018

et al. 2018

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“…Risk factors, including age, sex, tobacco use, cholesterol levels, hypertension and diabetes mellitus, were grouped following the recommendations of a previous study [23]. Considering that the population of Navarra has higher levels of HDLcholesterol on average, a specifically adapted version of the Framingham-Wilson Coronary Risk Equation was used to assess global cardiovascular risk: RIsk score for CORonary events in the population of NAvarra (RICORNA) [24].…”

Section: Methodsmentioning

confidence: 99%

Elevated circulating metalloproteinase 7 predicts recurrent cardiovascular events in patients with carotid stenosis: a prospective cohort study

Pérez‐Fernández

Irimia

Rodríguez

et al. 2020

BMC Cardiovasc Disord

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Background: Major adverse cardiovascular events are the main cause of morbidity and mortality over the long term in patients undergoing carotid endarterectomy. There are few reports assessing the prognostic value of markers of inflammation in relation to the risk of cardiovascular disease after carotid endarterectomy. Here, we aimed to determine whether matrix metalloproteinases (MMP-1, MMP-2, MMP-7, MMP-9 and MMP-10), tissue inhibitor of MMPs (TIMP-1) and in vivo inflammation studied by 18 F-FDG-PET/CT predict recurrent cardiovascular events in patients with carotid stenosis who underwent endarterectomy. Methods: This prospective cohort study was carried out on 31 consecutive patients with symptomatic (23/31) or asymptomatic (8/31) severe (> 70%) carotid stenosis who were scheduled for carotid endarterectomy between July 2013 and March 2016. In addition, 26 healthy controls were included in the study. Plasma and serum samples were collected 2 days prior to surgery and tested for MMP-1, MMP-2, MMP-7, MMP-9, MMP-10, TIMP-1, high-density lipoprotein, low-density lipoprotein, high-sensitivity C-reactive protein and erythrocyte sedimentation rate. 18 F-FDG-PET/CT focusing on several territories' vascular wall metabolism was performed on 29 of the patients because of no presurgical availability in 2 symptomatic patients. Histological and immunohistochemical studies were performed with antibodies targeting MMP-10, MMP-9, TIMP-1 and CD68. Results: The patients with carotid stenosis had significantly more circulating MMP-1, MMP-7 and MMP-10 than the healthy controls. Intraplaque TIMP-1 was correlated with its plasma level (r = 0.42 P = .02) and with 18 F-FDG uptake (r = 0.38 P = .05). We did not find any correlation between circulating MMPs and in vivo carotid plaque metabolism assessed by 18 F-FDG-PET. After a median follow-up of 1077 days, 4 cerebrovascular, 7 cardiovascular and 11 peripheral vascular events requiring hospitalization were registered. Circulating MMP-7 was capable of predicting events over and above the traditional risk factors (HR = 1.15 P = .006). When the model was associated with the variables of interest, the risk predicted by 18 F-FDG-PET was not significant. Conclusions: Circulating MMP-7 may represent a novel marker for recurrent cardiovascular events in patients with moderate to severe carotid stenosis. MMP-7 may reflect the atherosclerotic burden but not plaque inflammation in this specific vascular territory.

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Barriers to cardiovascular disease risk scoring and primary prevention in Europe

Hobbs

Jukema

Silva

et al. 2010

QJM

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The prevalence and burden of cardiovascular disease (CVD) is high, and it remains the leading cause of death worldwide. Unfortunately, many individuals who are at high risk for CVD are not recognized and/or treated. Therefore, programs are available to ensure individuals at risk for CVD are identified through appropriate risk classification and offered optimal preventative interventions. The use of algorithms to determine a global risk score may help to achieve these goals. Such global risk-scoring algorithms takes into account the synergistic effects between individual risk factors, placing increases in individual risk factors into context relative to the overall disease, allowing for a continuum of disease risk to be expressed, and identifying patients most likely to derive benefit from an intervention. The predictive value of risk scoring such as using the Framingham equation is reasonable, analogous to cervical screening, with area under the receiver operated characteristic curve a little over 70%. However, limitations do exist, and as they are identified adjustments can be made to the global risk-scoring algorithms. Limitations include patient-specific issues, such as variations in lifetime risk level, ethnicity or socio-economic strata, and algorithm-specific issues, such as discrepancies between different algorithms arising from varying risk factors evaluated. The use of currently developed algorithms is low in general practice, in part, because of the belief that the assessment may oversimplify the risk and/or lead to medication overuse. Additional hindrances to the use of risk scoring include government or local health policy, patient compliance issues and lack of time. A thorough, easy-to-use, and standardized tool for risk estimation would allow for improvements in the primary prevention of CVD.

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Adaptation of the Framingham-Wilson Coronary Risk Equation for the Population of Navarra (RICORNA)

Cited by 3 publications

References 30 publications

Recomendaciones preventivas cardiovasculares. Actualización PAPPS 2018

Recomendaciones preventivas cardiovasculares. Actualización PAPPS 2018

Elevated circulating metalloproteinase 7 predicts recurrent cardiovascular events in patients with carotid stenosis: a prospective cohort study

Barriers to cardiovascular disease risk scoring and primary prevention in Europe

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