2024
DOI: 10.1101/2024.11.29.626100
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Adaptation of the tetracycline-repressible system for modulating the expression of essential genes inCryptococcus neoformans

Ci Fu,
Nicole Robbins,
Leah E. Cowen

Abstract: The opportunistic human fungal pathogen Cryptococcus neoformans has an enormous impact on human health as the causative agent of cryptococcal meningitis, an AIDS-defining illness that results in significant human mortality. To combat C. neoformans infections, there is a dire need to expand our current antifungal arsenal. Essential gene products often serve as ideal targets for antimicrobials, and thus identifying and characterizing essential genes in a pathogen of interest is critical for drug development. Unf… Show more

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