Adaptation to lateral displacement of vision in patients with lesions of the central nervous system

Weiner, Mark J.; Hallett, Mark; Funkenstein, H. Harris

doi:10.1212/wnl.33.6.766

Cited by 387 publications

(254 citation statements)

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“…In accordance with literature (Deuschl et al 1996;Diedrichsen et al 2005;Gauthier et al 1979;Martin et al 1996;Maschke et al 2004;Tseng et al 2007;Weiner et al 1983), we found that patients adapted less well than controls. Also in accordance with previous work (Martin et al 1996;Maschke et al 2004;Weiner et al 1983), the deficit was not limited to the adaptation phase, but rather continued undiminished The third data column presents the outcome of group comparisons with t tests, and the last two columns are the correlations of patients' findings with ataxia scores and cerebellar volume. Symbols ***, **, and * indicate p \ 0.001, p \ 0.01, and p \ 0.05, respectively, and the absence of a symbol indicates p [ 0.05 Fig.…”

Section: Discussionsupporting

confidence: 93%

“…The cerebellum has also been implicated in a more complex form of motor learning, namely, sensorimotor adaptation to visual and mechanical distortions. This view is supported by clinical studies, which found that adaptation is often reduced or abolished in patients with cerebellar disease (Deuschl et al 1996;Diedrichsen et al 2005;Gauthier et al 1979;Martin et al 1996;Maschke et al 2004;Tseng et al 2007;Weiner et al 1983). Further support comes from functional neuroimaging studies, which observed an increase of cerebellar activity during an adaptation task (e.g., Flament et al 1996;Graydon et al 2005;Imamizu et al 2000;Krakauer et al 2004;Krebs et al 1998;Lang et al 1988).…”

Section: Introductionmentioning

confidence: 91%

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The effect of cerebellar cortical degeneration on adaptive plasticity and movement control

2008

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Clinical and neuroimaging studies provide converging evidence that the cerebellum plays an important role for sensorimotor adaptation by participating in the adaptive process per se, and/or by evaluating motor performance errors as a prerequisite for adaptation. Recent experimental evidence suggests that error signals pertinent to adaptation are related to sensory prediction rather than to online corrections (Tseng et al. in J Neurophysiol 98(1):54-62, 2007). To further elucidate the role of the cerebellum, the present study uses a multiple regression approach to separate out three independent determinants of adaptive success. Seventeen patients with cerebellar atrophy but without extra-cerebellar lesions, and 17 healthy, sex-and age-matched controls participated. Both subject groups performed center-out pointing movements before, during, and after exposure to 60°rotated visual feedback. From the registered data, we quantified four indicators of adaptive success (adaptive improvement, retention without feedback, intermanual transfer, and de-adaptation under normal feedback), as well as five measures of motor performance (reaction time, peak velocity, movement time, response variability, and ability for online error corrections). The variance of each adaptation indicator was then partitioned into three components, one related to subject group but not to motor performance, a second related to group and motor performance, and a third related to motor performance but not to group. In accordance with previous work, adaptation and motor performance were degraded in patients. The deficit was similar in magnitude for all four adaptation indicators, which suggests that adaptive recalibration rather than strategic control were affected in our patients. No adaptation indicator shared statistically significant variance with group alone; we therefore found no evidence for cerebellar circuitry dedicated to adaptation but not motor performance. Three indicators shared significant variance jointly with group and motor performance; this suggests that the cerebellar contribution to motor performance is related to adaptive success. All four indicators shared significant variance with motor performance alone; this indicates that extracerebellar contributions to motor performance are also related to adaptive success. In conclusion, our data support the view that neural structures inside and outside the cerebellum are processing motor performance-related signals as a prerequisite for adaptation, but provide no evidence for a cerebellar structure related exclusively to adaptation.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 91%

The effect of cerebellar cortical degeneration on adaptive plasticity and movement control

2008

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“…is in receipt of a SERC studentship. The cerebellum has been implicated in the motor learning of hand-eye coordination tasks (Baizer & Glickstein, 1974;Weiner et al 1983). However, in a recent study (Cody et al 1992) we found no evidence that the inaccuracies of visuo-motor tracking shown by patients with cerebellar lesions resulted from deficits of learning or memory.…”

Section: Ipcontrasting

confidence: 61%

Proceedings of the Physiological Society, 23‐25 September 1992, Cambridge Meeting: Poster Communications

1993

The Journal of Physiology

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“…Pointing errors are thus usually assumed to disappear completely within a few trials. However, using a similar procedure of terminal error feedback, Weiner, Hallett, and Funkenstein (1983) noticed that a pointing bias of about 15% persisted after 25 pointing trials. Devane (1968) showed that the decrease of pointing errors over time during the recovery from wedge prism adaptation was also asymptotic.…”

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confidence: 99%

Prismatic displacement of vision induces transient changes in the timing of eye-hand coordination

Rossetti

Koga

Mano

1993

Perception & Psychophysics

116

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Eye-hand coordination was investigated during a task of finger pointing toward visual targets viewed through wedge prisms. Hand and eye latencies and movement times were identical during the control condition and at the end of prism exposure. A temporal reorganization of eye and hand movements was observed during the course of adaptation. During the earlier stage of prism exposure, the time gap between the end of the eye saccade and the onset of hand movement was increased from a control time of 23 to 68 msec. This suggests that a time-consuming process occurred during the early prism-exposure period. The evolution of this time gap was correlated with the evolution of pointing errors during the early stage of prism exposure, in such a way that both measures increased at the onset of prism exposure and decreased almost back to control values within about 10 trials. However, spatial error was not entirely corrected, even late in prism exposure when the temporal organization of eye and hand had returned to baseline. These data suggest that two different adaptive mechanisms were at work: a rather short-term mechanism, involved in normal coordination of spatially aligned eye and hand systems, and a long-term mechanism, responsible for remapping spatially misaligned systems. The former mechanism can be strategically employed to quickly optimize accuracy in a situation involving misalignment, but completely adaptive behavior must await the slower-acting latter mechanism to achieve longterm spatial alignment.The human organism is able to adapt to many kinds of optical transformations of a visual scene. Since the end of the last century, a considerable amount of work has been performed on prism adaptation, especially on the locus of adaptation (see reviews in Koga, 1988;Kohler, 1962;Kornheiser, 1976;Welch, 1986). The different theories of prism adaptationcan be classifiedinto three main groups, based on the hypothesized nature of adaptation: arm proprioceptive change (Harris, 1963), central change in plurimodal coordination (Hardt, Held, & Steinbach, 1971; This work was supported by the Liaison Universite-Industrie, Rayonnement International, Lyon, France, the French Ministry of Research and Technology and Human Frontiers Science Program to Y.R., and by the grant in aid for developmental scientific research(6381002)from the Ministry of Education, Science and Culture of Japan to K.K. The authors are pleased to acknowledge Takara Tashiro, of Osaka City University, for providing the prisms used in this experiment, Hirokazu Yoshimura, of Kanazawa City University, for valuable comments about the experimental design and procedure, Kenji Susami, of Chukyo University, Nagoya, for his skillful help in the experimental hardware design and construction, Marc Jeannerod, and Claude Prablanc, of INSERM, Lyon, Alan Hein, of MIT, and Karen Reinkeof the University of Arizona, for thoughtful comments on the manuscript, and the voluntary subjects from the Department of Psychology, Nagoya University. We are especially indebted to an anon...

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Adaptation to lateral displacement of vision in patients with lesions of the central nervous system

Cited by 387 publications

References 0 publications

The effect of cerebellar cortical degeneration on adaptive plasticity and movement control

The effect of cerebellar cortical degeneration on adaptive plasticity and movement control

Proceedings of the Physiological Society, 23‐25 September 1992, Cambridge Meeting: Poster Communications

Prismatic displacement of vision induces transient changes in the timing of eye-hand coordination

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