Adapted dietary inflammatory index and its association with a summary score for low-grade inflammation and markers of glucose metabolism: the Cohort study on Diabetes and Atherosclerosis Maastricht (CODAM) and the Hoorn study

Woudenbergh, Geertruida J. van; Theofylaktopoulou, Despoina; Kuijsten, Anneleen; Ferreira, Isabel; Greevenbroek, Marleen M.J. van; Kallen, C. J. van der; Schalkwijk, Casper G.; Stehouwer, Coen D. A.; Ocké, Marga C.; Nijpels, Giel; Dekker, Joost; Blaak, Ellen E.; Feskens, Edith J. M.

doi:10.3945/ajcn.112.056333

Cited by 152 publications

(204 citation statements)

References 35 publications

Supporting

Mentioning

165

Contrasting

Unclassified

Order By: Relevance

“…Previously, we observed that women with a pro-inflammatory diet (higher DII scores) had a higher risk of developing CRC in a US-based cohort study (Shivappa et al 2014a). Furthermore, higher DII scores have been linked to asthma (Wood et al 2014), and using a modification of the previous DII version (Hebert et al 2014), a positive association was observed between the DII and higher concentrations of glucose metabolism markers (van Woudenbergh et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Dietary inflammatory index and inflammatory gene interactions in relation to colorectal cancer risk in the Bellvitge colorectal cancer case–control study

et al. 2014

View full text Add to dashboard Cite

Chronic inflammation is an important factor in colorectal carcinogenesis. However, evidence on the effect of pro-inflammatory and anti-inflammatory foods and nutrients is scarce. Moreover, there are few studies focusing on diet-gene interactions on inflammation and colorectal cancer (CRC). This study was designed to investigate the association between the novel dietary inflammatory index (DII) and CRC and its potential interaction with polymorphisms in inflammatory genes. Data from the Bellvitge Colorectal Cancer Study, a case-control study (424 cases with incident colorectal cancer and 401 hospital-based controls), were used. The DII score for each participant was obtained by multiplying intakes of dietary components from a validated dietary history questionnaire by literature-based dietary inflammatory weights that reflected the inflammatory potential of components. Data from four important single nucleotide polymorphisms located in genes thought to be important in inflammationassociated CRC: i.e., interleukin (IL)-4, IL-6, IL-8, and peroxisome proliferator-activated receptor-c (PPARG) were analyzed. A direct association was observed between DII score and CRC risk (OR Q4 vs. Q1 1.65, 95 % CI 1.05-2.60, and P trend 0.011). A stronger association was found with colon cancer risk (OR Q4 vs. Q1 2.24, 95 % CI 1.33-3.77, and P trend 0.002) than rectal cancer risk (OR Q4 vs. Q1 1.12, 95 % CI 0.61-2.06, and P trend 0.37). DII score was inversely correlated with SNP rs2243250 in IL-4 among controls, and an interaction was observed with CRC risk. Neither correlation nor interaction was detected for other inflammatory genes. Overall, high-DII diets are associated with increased risk of CRC, particularly for colon cancer, suggesting that dietary-mediated inflammation plays an important role in colorectal carcinogenesis.Electronic supplementary material The online version of this article

show abstract

Section: Introductionmentioning

confidence: 99%

Dietary inflammatory index and inflammatory gene interactions in relation to colorectal cancer risk in the Bellvitge colorectal cancer case–control study

et al. 2014

View full text Add to dashboard Cite

show abstract

“…To obtain a robust measure of overall inflammation and endothelial dysfunction we computed composite scores as described before (30,32,33). With these composite scores we reduce biological variability and random error of each individual variable, and we gain statistical efficiency.…”

Section: Statistical Analysis and Study Powermentioning

confidence: 99%

“…In CODAM, IL6, SAA, sICAM1, sE-selectin, and sVCAM1 were also measured by ELISA and CRP was also measured in serum by high-sensitivity immunoturbidimetry (31). Values obtained by ELISA or immunoturbidimetry assay were calibrated on the values obtained by multi-array and the calibrated and multi-array values were averaged for CODAM (30). von Willebrand factor (vWF) was determined in citrated plasma by means of ELISA (29).…”

Section: Markers Of Low-grade Inflammation and Endothelial Dysfunctionmentioning

confidence: 99%

“…Plasma markers of low-grade inflammation (C-reactive protein (CRP), interleukin 6 (IL6), interleukin 8 (IL8), tumor necrosis factor alpha (TNFa), serum amyloid A (SAA), and soluble intercellular adhesion molecule 1 (sICAM1)) and plasma markers of endothelial dysfunction (soluble E-selectin (sE-selectin) and soluble vascular cell adhesion molecule 1 (sVCAM1)) were measured by multiarray based on electro-chemiluminescence technology (MesoScaleDiscovery, SECTOR Imager 2400, Gaithersburg, MD, USA) as previously described for Hoorn (29) and CODAM (30). In CODAM, IL6, SAA, sICAM1, sE-selectin, and sVCAM1 were also measured by ELISA and CRP was also measured in serum by high-sensitivity immunoturbidimetry (31).…”

Section: Markers Of Low-grade Inflammation and Endothelial Dysfunctionmentioning

confidence: 99%

See 1 more Smart Citation

BclI glucocorticoid receptor polymorphism in relation to cardiovascular variables: the Hoorn and CODAM studies

Moorsel

Greevenbroek

Schaper

et al. 2015

European Journal of Endocrinology

Self Cite

View full text Add to dashboard Cite

Objective: Excess glucocorticoids are known to cause hypertension and cardiovascular disease (CVD). The BclI glucocorticoid receptor (GR) polymorphism increases glucocorticoid sensitivity and is associated with adverse metabolic effects. Previous studies investigating cardiovascular implications have shown inconsistent results. Therefore, the aim of the present study was to investigate the association of the BclI polymorphism with blood pressure, atherosclerosis, low-grade inflammation, endothelial dysfunction, and prevalent CVD. Design: Observational cohort study, combining two cohort studies designed to investigate genetic and metabolic determinants of CVD. Methods: We genotyped 1228 individuals (aged 64.7 yearsG8.5) from the Cohort on Diabetes and Atherosclerosis Maastricht (CODAM) study and Hoorn study for the BclI polymorphism. We measured blood pressure, ankle-brachial index (ABI), and carotid intima-media thickness (cIMT). Low-grade inflammation and endothelial dysfunction scores were computed by averaging Z-scores of six low-grade inflammation markers and four endothelial dysfunction markers respectively. Prevalent CVD was assessed with questionnaires, hospital records, ECG, and ABI. Results: Homozygous carriers (GG) had higher mean arterial pressure (103.8G12.4 mmHg vs 101.6G12.2 mmHg (meanGS.D.); P!0.05) compared with non-carriers (CC). Homozygous carriers had lower ABI compared with heterozygous carriers (CG) (1.08G0.13 vs 1.11G0.14; P!0.05). After adjustment for all covariates in the full model, the association with ABI was no longer significant. BclI was not associated with systolic blood pressure, cIMT, low-grade inflammation, endothelial dysfunction, and prevalent CVD. Conclusions: The BclI polymorphism of the GR gene may contribute to an unfavorable cardiovascular profile; however, the effects on cardiovascular variables appear to be limited and partly mediated by the metabolic phenotype exerted by BclI.

show abstract

“…Waist circumference was ascertained with a measuring tape at the level of umbilicus. Blood samples were drawn after an overnight fast for measurement of glycated hemoglobin (HbA 1c ), plasma glucose, insulin, total cholesterol, HDL cholesterol, and triglycerides, as described elsewhere (24,25). LDL cholesterol was calculated by the Friedewald formula.…”

Section: Measurementsmentioning

confidence: 99%

A Common Gene Variant in Glucokinase Regulatory Protein Interacts With Glucose Metabolism on Diabetic Dyslipidemia: the Combined CODAM and Hoorn Studies

et al. 2016

Self Cite

View full text Add to dashboard Cite

OBJECTIVESmall molecules that disrupt the binding between glucokinase and glucokinase regulatory protein (GKRP) are potential new glucose-lowering targets. They stimulate hepatic glucose disposal by increasing glucokinase activity in the liver. It can, however, be anticipated that increased hepatic glucokinase activity might be accompanied by the development of hypertriglyceridemia, particularly in type 2 diabetes. We examined whether the strength of association between rs1260326, a common, functional gene variant in GKRP, and plasma lipids is affected by glucose metabolism. RESEARCH DESIGN AND METHODSrs1260326 was genotyped in subjects with normal glucose metabolism (n = 497), subjects with impaired glucose metabolism (n = 256), and patients with type 2 diabetes (n = 351) in the combined Hoorn and Cohort on Diabetes and Atherosclerosis Maastricht (CODAM) studies. RESULTSThe strength of association between the rs1260326 minor T allele and plasma triglycerides increased from normal glucose metabolism to impaired glucose metabolism to type 2 diabetes (P for interaction = 0.002). The inverse relation between rs1260326 and plasma HDL cholesterol was again most prominent in type 2 diabetes (P for interaction = 0.004). Similar trends were observed when the Hoorn and CODAM cohorts were analyzed separately. Comparable results were obtained when glucose metabolism strata were replaced by continuous indices of glucose metabolism, i.e., HbA 1c and fasting plasma glucose. CONCLUSIONSThese findings illustrate that common gene variants, such as rs1260326, can have substantial effect sizes when they are studied in specific populations, such as type 2 diabetes. Moreover, our results shed light on potential side effects of small molecule disruptors of the GKRP-glucokinase complex, especially when glucose control is suboptimal.

show abstract

Adapted dietary inflammatory index and its association with a summary score for low-grade inflammation and markers of glucose metabolism: the Cohort study on Diabetes and Atherosclerosis Maastricht (CODAM) and the Hoorn study

Abstract: The significant mediating role of low-grade inflammation in the association between the ADII and HOMA-IR suggests that inflammation might be one of the pathways through which diet affects insulin resistance.

Cited by 152 publications

References 35 publications

Dietary inflammatory index and inflammatory gene interactions in relation to colorectal cancer risk in the Bellvitge colorectal cancer case–control study

Dietary inflammatory index and inflammatory gene interactions in relation to colorectal cancer risk in the Bellvitge colorectal cancer case–control study

BclI glucocorticoid receptor polymorphism in relation to cardiovascular variables: the Hoorn and CODAM studies

A Common Gene Variant in Glucokinase Regulatory Protein Interacts With Glucose Metabolism on Diabetic Dyslipidemia: the Combined CODAM and Hoorn Studies

Contact Info

Product

Resources

About