This systematic review examines the challenges and potential solutions to improve the implementation of collaborative learning and e-learning environments in universities. The article analyzes 200 relevant articles published between 2014-2022 using a qualitative approach to identify themes and sub-themes related to collaborative learning and e-learning environments. The study reveals various learning methods employed, including MOOC (Massive Open Online Course), digital mind maps, and tripartite learning, but also highlights challenges such as lack of digital infrastructure, low-quality internet networks, and inadequate practical tools. The research emphasizes the need for effective leadership and management in vocational institutions and recommends further research on curriculum development, learning evaluation methods, lecturer performance assessment, and improving digital infrastructure and educator training. Collaboration with industry and other training institutions is also suggested to improve students' employability and entrepreneurship skills.