Abstract-The effectiveness of teaching university students in large-class has been debated since 1924. In China, the popularity of higher education in 1999 makes overwhelming rise to school-age youth to enter universities; hence, large-class teaching even has become an important form of curriculum for English major. However, previous research literature reveals that the main mode of large-class teaching is giving lectures and doing interactive teaching in writing and some selected or optional courses, but less in discussing in teaching of listening. Listening is a skill course. How to guarantee the teaching quality and students' interest in learning the skill in a large class; how to consciously improve students' autonomous learning, and the professional listening class teaching on webbased autonomous learning strategy give many inspirations. This paper analyzes two different classes (CA and CB) with different teaching methods and strategies via questionnaire survey. We found out in large class web-based autonomous listening teaching, correctly and properly applied learning strategies will greatly achieve listening performance, develop and cultivate students listening abilities. It also explores the feasibility and effectiveness of a large-class in teaching listening based on web-based autonomous instruction.