Currently, the most implemented solution for driving a pumping system (PS) at variable speed is using a variable frequency drive (VFD). Because most of the VFDs have integrated only one proportional-integral (PI) frequency controller whose parameters (proportional gain/the integration time) can be off-line tuned but cannot be changed during real-time operation, and many PS must operate in different regimes (at variable speed, variable flow rate, at variable pumping head or even at variable power, e.g., those powered by renewable energy sources), the adaptive control strategy proposed in this paper overcomes these problems with very good performances. The proposed adaptive control strategy uses only simple PI controllers for managing several operating regimes. The adaptive character is not ensured by re-tuning the PI controller parameters as in self-tuning controllers but by readjusting the control law through a change in the control loop depending on the controlled output of the process (pump speed, pump discharge, pumping head or absorbed power). The deviations of the mentioned controlled outputs from their referenced values are converted into electrical frequency error (the deviation of the current value from its reference), which is the regular input to the already tuned controller; therefore, no controller re-tuning is required.