The problem of reliable control for variable fault systems under linear quadratic Gaussian (LQG) framework is studied in this paper. Firstly, a cluster of models is used to cover the dynamic behaviors of different fault modes of a system and, for each model, LQG control is implemented. By using the a posteriori probability of model innovation as the weight information, a multi-model reliable control (MMRC) is proposed. Secondly, it is proved that MMRC can enable the controller to learn the real operating mode of the system. When the controller is in a deadlock state, a deadlock avoidance strategy is given and its convergence of the a posteriori probability is proved. Finally, the validity of MMRC is verified by an example simulation of the lateral-directional control system of an aircraft. Simulation results show that MMRC guarantees an acceptable performance of the closed-loop system. In addition, since the controller fuses the control law of each model according to the weight information, when the system model is switched, the controller implements a soft switching, which avoids the jitter caused by frequent hard switching to the system.