Adaptive evolution drives divergence of a hybrid inviability gene between two species of Drosophila

Presgraves, Daven C.; Balagopalan, Lakshmi; Abmayr, Susan M.; Orr, H. Allen

doi:10.1038/nature01679

Cited by 381 publications

(338 citation statements)

References 40 publications

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“…Indeed, consistent with the idea that genomic conflict is a common phenomenon, detailed analysis of hybrids showed that ''speciation'' genes tend to be involved in intragenomic conflict, but their effect could be only detected in hybrids (Perez et al 1993;Dermitzakis et al 2000;Tao et al 2001;Presgraves et al 2003;Phadnis and Orr 2009;Tang and Presgraves 2009).…”

mentioning

confidence: 74%

“…CG11943, a homolog of the human NUP205 gene, shows strong evidence of ongoing selection in D. mauritiana and D. simulans. Presgraves et al (2003) and Tang and Presgraves (2009) previously identified Nup96 and Nup160 as one cause of hybrid lethality between D. simulans and D. melanogaster, due to an interaction with an as-yetunidentified X-linked factor. Given that CG11943 is located on the X chromosome, we speculate that it may be an alternative interaction partner of Nup160 and/or Nup96 instead of (or in addition to) their suggested Nup153.…”

Section: Nucleoporins As a Preferential Target For Positive Selectionmentioning

confidence: 99%

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Genome-wide patterns of natural variation reveal strong selective sweeps and ongoing genomic conflict in Drosophila mauritiana

Nolte¹,

Pandey²,

Kofler³

et al. 2012

Genome Res.

117

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Although it is well understood that selection shapes the polymorphism pattern in Drosophila, signatures of classic selective sweeps are scarce. Here, we focus on Drosophila mauritiana, an island endemic, which is closely related to Drosophila melanogaster. Based on a new, annotated genome sequence, we characterized the genome-wide polymorphism by sequencing pooled individuals (Pool-seq). We show that the interplay between selection and recombination results in a genome-wide polymorphism pattern characteristic for D. mauritiana. Two large genomic regions (>500 kb) showed the signature of almost complete selective sweeps. We propose that the absence of population structure and limited geographic distribution could explain why such pronounced sweep patterns are restricted to D. mauritiana. Further evidence for strong adaptive evolution was detected for several nucleoporin genes, some of which were not previously identified as genes involved in genomic conflict. Since this adaptive evolution is continuing after the split of D. mauritiana and Drosophila simulans, we conclude that genomic conflict is not restricted to short episodes, but rather an ongoing process in Drosophila.

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mentioning

confidence: 74%

Section: Nucleoporins As a Preferential Target For Positive Selectionmentioning

confidence: 99%

Genome-wide patterns of natural variation reveal strong selective sweeps and ongoing genomic conflict in Drosophila mauritiana

Nolte¹,

Pandey²,

Kofler³

et al. 2012

Genome Res.

117

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show abstract

“…Although the recent speciation literature has appropriately emphasized the role of selection in the development of reproductive isolation (19)(20)(21)(22), the present study provides a possible counterexample; because of selfing, genetic drift could provide an efficient means for the accumulation of hybrid incompatibilities.…”

Section: Discussionmentioning

confidence: 99%

High biological species diversity in the arctic flora

Grundt

Kjølner²,

Borgen³

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

128

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The arctic flora is considered to be impoverished, but estimates of species diversity are based on morphological assessments, which may not provide accurate counts of biological species. Here we report on crossing relationships within three diploid circumpolar plant species in the genus Draba (Brassicaceae). Although 99% of parental individuals were fully fertile, the fertility of intraspecific crosses was surprisingly low. Hybrids from crosses within populations were mostly fertile (63%), but only 8% of the hybrids from crosses within and among geographic regions (Alaska, Greenland, Svalbard, and Norway) were fertile. The frequent occurrence of intraspecific crossing barriers is not accompanied by significant morphological or ecological differentiation, indicating that numerous cryptic biological species have arisen within each taxonomic species despite their recent (Pleistocene) origin.crossing relationships ͉ cryptic species ͉ Draba ͉ speciation ͉ postmating isolation T he Arctic f lora has long been viewed as depauperate.Indeed, the decrease in biological diversity with increasing latitude is one of the oldest recognized patterns in ecology (1). Diversity has, however, typically been quantified as the number of morphological or ''taxonomic'' species. Little is known about biological species diversity in the Arctic (2), because the recognition of biological species requires information on reproductive isolation.Here we present results from crossing experiments within three diploid circumpolar plant species: Draba fladnizensis, Draba nivalis, and Draba subcapitata (Table 1, which is published as supporting information on the PNAS web site). Low levels of genetic differentiation within and among the species suggest they originated recently, probably within the last one million years (3). The species are mainly self-pollinated (4), but they occasionally outcross as demonstrated by reports of natural hybrids between D. fladnizensis and D. nivalis (5). We show that, contrary to expectations based on observations of limited morphological, ecological, and genetic diversity, numerous cryptic biological species have arisen within each of the taxonomic species studied here. These results imply that biological species diversity may be considerably higher in arctic regions than previously believed. ResultsAll of the 79 parental plants of D. fladnizensis and D. nivalis and six of the seven parental plants of D. subcapitata were highly fertile ( Table 1). The within-population crosses mostly generated fertile hybrids (10 of 16 crosses attempted), but six crosses resulted in semisterile hybrids (Tables 2 and 3, which are published as supporting information on the PNAS web site). The within-region crosses (among populations in Alaska) generated hybrids that were semisterile in D. fladnizensis ( Fig. 1 and Tables 2 and 3) and mostly sterile in D. nivalis (Fig. 2 and Tables 2 and 3). Likewise, the majority of crosses among regions resulted in sterile Correlations between geographic and genetic amplified fragment length polym...

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“…Although selection on leaf size has not been directly assessed for Antirrhinum, species with small leaves (e.g., A. charidemi, A. microphyllum, and A. mollisimum) are found in the driest habitats encountered by the group, consistent with water limitation playing a role. Moreover, all seven QTL influencing values of PC1, the PC with the major effect on leaf area, act in the same direction as that of the parental difference, consistent with their having been subject to directional selection (30)(31)(32). The expected directions of size selection can be visualized in allometric space as vectors with major components at right angles to (normal to) the area isosurfaces ( Fig.…”

Section: Discussionmentioning

confidence: 99%

Evolution through genetically controlled allometry space

Langlade

Feng

Dransfield

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

139

170

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Understanding evolutionary change requires phenotypic differences between organisms to be placed in a genetic context. However, there are few cases where it has been possible to define an appropriate genotypic space for a range of species. Here we address this problem by defining a genetically controlled space that captures variation in shape and size between closely related species of Antirrhinum. The axes of the space are based on an allometric model of leaves from an F 2 of an interspecific cross between Antirrhinum majus and Antirrhinum charidemi. Three principal components were found to capture most of the genetic variation in shape and size, allowing a three-dimensional allometric space to be defined. The contribution of individual genetic loci was determined from QTL analysis, allowing each locus to be represented as a vector in the allometric space. Leaf shapes and sizes of 18 different Antirrhinum taxa, encompassing a broad range of leaf morphologies, could be accurately represented as clouds within the space. Most taxa overlapped with, or were near to, at least one other species in the space, so that together they defined a largely interconnected domain of viable forms. It is likely that the pattern of evolution within this domain reflects a combination of directional selection and evolutionary tradeoffs within a high dimensional space.leaf ͉ morphometry ͉ QTL analysis ͉ shape variation ͉ species

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Adaptive evolution drives divergence of a hybrid inviability gene between two species of Drosophila

Cited by 381 publications

References 40 publications

Genome-wide patterns of natural variation reveal strong selective sweeps and ongoing genomic conflict in Drosophila mauritiana

Genome-wide patterns of natural variation reveal strong selective sweeps and ongoing genomic conflict in Drosophila mauritiana

High biological species diversity in the arctic flora

Evolution through genetically controlled allometry space

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