Adaptive evolution of chloroplast division mechanisms during plant terrestrialization

Liu, Moyang; Yu, Jing; Yang, Ming; Cao, Lingyan; Chen, Cheng

doi:10.1016/j.celrep.2024.113950

Cited by 2 publications

(1 citation statement)

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“…Subsequently, the C-termini of FtsZ1 and FtsZ2 underwent functional differentiation. This divergence likely reflects evolution of specialized chloroplast division proteins like PLASTID DIVISION2 (PDV2) in streptophytes, MULTIPLE CHLOROPLAST DIVISION SITE1 (MCD1) in bryophytes, and PLASTID DIVISION1 (PDV1) and PARALOG OF ARC6 (PARC6) in ferns, whose impacts on FtsZ functionality requires further exploration ( Miyagishima 2011 ; Miyagishima et al 2011 ; Liu et al 2024 ).…”

Section: Discussionmentioning

confidence: 99%

Evolution and Functional Differentiation of the C-terminal Motifs of FtsZs During Plant Evolution

An,

Wang,

Hong

et al. 2024

Molecular Biology and Evolution

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Filamentous temperature-sensitive Z (FtsZ) is a tubulin-like GTPase that is highly conserved in bacteria and plants. It polymerizes into a ring at the division site of bacteria and chloroplasts and serves as the scaffold protein of the division complex. While a single FtsZ is present in bacteria and cyanobacteria, there are two subfamilies, FtsZ1 and FtsZ2 in the green lineage, and FtsZA and FtsZB in red algae. In Arabidopsis thaliana, the C-terminal motifs of AtFtsZ1 (Z1C) and AtFtsZ2-1 (Z2C) display distinct functions in the regulation of chloroplast division. Z1C exhibits weak membrane-binding activity, whereas Z2C engages in the interaction with the membrane protein AtARC6. Here, we provide evidence revealing the distinct traits of the C-terminal motifs of FtsZ1 and FtsZ2 throughout the plant evolutionary process. In a range of plant species, the C-terminal motifs of FtsZ1 exhibit diverse membrane-binding properties critical for regulating chloroplast division. In chlorophytes, the C-terminal motifs of FtsZ1 and FtsZ2 exhibit both membrane-binding and protein interaction functions, which are similar to those of cyanobacterial FtsZ and red algal FtsZA. During the transition from algae to land plants, the functions of the C-terminal motifs of FtsZ1 and FtsZ2 exhibit differentiation. FtsZ1 lost the function of interacting with ARC6 in land plants, and the membrane-binding activity of FtsZ2 was lost in ferns. Our findings reveal the functional differentiation of the C-terminal motifs of FtsZs during plant evolution, which is critical for chloroplast division.

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Section: Discussionmentioning

confidence: 99%